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Aliases for RGS3 Gene

Aliases for RGS3 Gene

  • Regulator Of G Protein Signaling 3 2 3 5
  • Regulator Of G-Protein Signalling 3 2 3
  • Regulator Of G-Protein Signaling 3 2 3
  • RGP3 3 4
  • C2PA 3

External Ids for RGS3 Gene

Previous GeneCards Identifiers for RGS3 Gene

  • GC09P107022
  • GC09P107956
  • GC09P109678
  • GC09P111600
  • GC09P113303
  • GC09P115262
  • GC09P116207
  • GC09P085814
  • GC09P113448
  • GC09P113549
  • GC09P113551
  • GC09P113604
  • GC09P113737
  • GC09P113866
  • GC09P113992
  • GC09P114119

Summaries for RGS3 Gene

Entrez Gene Summary for RGS3 Gene

  • This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

GeneCards Summary for RGS3 Gene

RGS3 (Regulator Of G Protein Signaling 3) is a Protein Coding gene. Among its related pathways are Ephrin B reverse signaling and Development A3 receptor signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS20.

UniProtKB/Swiss-Prot for RGS3 Gene

  • Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Gene Wiki entry for RGS3 Gene

Additional gene information for RGS3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS3 Gene

Genomics for RGS3 Gene

GeneHancer (GH) Regulatory Elements for RGS3 Gene

Promoters and enhancers for RGS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J113372 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.2 -66.7 -66729 11.9 HDGF PKNOX1 CLOCK FOXA2 ARNT MLX ARID4B SIN3A DMAP1 YBX1 HDHD3 RGS3 PRPF4 POLE3 C9orf43 RNF183 ALAD CDC26 BSPRY
GH09J113591 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 665.1 +152.7 152659 12.8 HDGF FOXA2 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 FOS SP3 RGS3 C9orf43 ALAD RNF183 LOC105376221 LOC105376222
GH09J113500 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 661.3 +58.7 58745 6.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 RXRA RGS3 C9orf43 ALAD RNF183 GC09P114257
GH09J113577 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 677.9 +135.5 135494 6.3 HDGF PKNOX1 SIN3A IRF4 YY1 ZNF207 ZNF143 ATF7 FOS RUNX3 RGS3 C9orf43 POLE3 ALAD RNF183 LOC105376221 GC09P114256
GH09J113563 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 665 +120.8 120777 3.1 HDAC1 PKNOX1 ARNT NFXL1 ZBTB40 POLR2B ATF7 IKZF2 RUNX3 EGR2 RGS3 C9orf43 PRPF4 RNF183 POLE3 CDC26 ALAD GC09P114256 GC09P114257
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS3 gene promoter:
  • AP-1
  • GR
  • HEN1
  • Pbx1a
  • ER-alpha
  • GR-alpha
  • Lmo2

Genomic Locations for RGS3 Gene

Genomic Locations for RGS3 Gene
chr9:113,444,729-113,597,743
(GRCh38/hg38)
Size:
153,015 bases
Orientation:
Plus strand
chr9:116,207,011-116,360,018
(GRCh37/hg19)
Size:
153,008 bases
Orientation:
Plus strand

Genomic View for RGS3 Gene

Genes around RGS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS3 Gene

Proteins for RGS3 Gene

  • Protein details for RGS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49796-RGS3_HUMAN
    Recommended name:
    Regulator of G-protein signaling 3
    Protein Accession:
    P49796
    Secondary Accessions:
    • A6NHA0
    • A8K0V1
    • B3KUB2
    • Q5VXB8
    • Q5VXC1
    • Q5VZ05
    • Q5VZ06
    • Q6ZRM5
    • Q8IUQ1
    • Q8NC47
    • Q8NFN4
    • Q8NFN5
    • Q8NFN6
    • Q8TD59
    • Q8TD68
    • Q8WV02
    • Q8WXA0

    Protein attributes for RGS3 Gene

    Size:
    1198 amino acids
    Molecular mass:
    132336 Da
    Quaternary structure:
    • Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.

    Three dimensional structures from OCA and Proteopedia for RGS3 Gene

    Alternative splice isoforms for RGS3 Gene

neXtProt entry for RGS3 Gene

Post-translational modifications for RGS3 Gene

No data available for DME Specific Peptides for RGS3 Gene

Domains & Families for RGS3 Gene

Gene Families for RGS3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS3: view

No data available for UniProtKB/Swiss-Prot for RGS3 Gene

Function for RGS3 Gene

Molecular function for RGS3 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
GENATLAS Biochemistry:
negative regulator of G protein signaling 3,functioning as GTPase-activating protein for G protein alpha i and q subunits,expressed in heart,skeletal muscle,lung and other tissues,C elegans EGL-10 and yeast SST2 homolog

Gene Ontology (GO) - Molecular Function for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 9858594
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with RGS3: view
genes like me logo Genes that share phenotypes with RGS3: view

Animal Model Products

CRISPR Products

miRNA for RGS3 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS3 Gene

Localization for RGS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS3 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS,IDA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS3: view

Pathways & Interactions for RGS3 Gene

genes like me logo Genes that share pathways with RGS3: view

Gene Ontology (GO) - Biological Process for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8602223
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9858594
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS3: view

No data available for SIGNOR curated interactions for RGS3 Gene

Drugs & Compounds for RGS3 Gene

(1) Drugs for RGS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RGS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS3: view

Transcripts for RGS3 Gene

Unigene Clusters for RGS3 Gene

Regulator of G-protein signaling 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10: - - -
SP11: -
SP12: - -
SP13:
SP14:
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SP17:
SP18:
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SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - -
SP27:
SP28:
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SP32:
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SP34:
SP35:
SP36:
SP37:
SP38:

ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e ^ 28a · 28b ^ 29a · 29b · 29c · 29d · 29e ^ 30a · 30b · 30c ^ 31a · 31b · 31c ^ 32 ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - -
SP15:
SP16: - - - - - - -
SP17:
SP18:
SP19: - - - - -
SP20: - - - - - -
SP21: - - - - - -
SP22: - - - - -
SP23: - - - - -
SP24: - - - - - - -
SP25: -
SP26:
SP27: - - - - - - - - - - - - - -
SP28: - - - - - - - -
SP29: - - - - - - -
SP30: - - - - - - -
SP31: - - - - -
SP32: - - - -
SP33: -
SP34:
SP35:
SP36:
SP37: - - - - - - - - - - - - - -
SP38:

ExUns: 33a · 33b · 33c · 33d · 33e · 33f ^ 34a · 34b · 34c · 34d · 34e · 34f · 34g · 34h · 34i · 34j · 34k · 34l ^ 35a · 35b ^ 36 ^ 37a · 37b · 37c · 37d · 37e ^
SP1:
SP2: - - - - - - - - - - - - - - - - - - - - - - - - -
SP3:
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - -
SP14: - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP17: - -
SP18:
SP19:
SP20: - - - - - -
SP21: - -
SP22: - -
SP23: - - - - - -
SP24: - -
SP25: - -
SP26:
SP27: - -
SP28: - - - - - -
SP29: - - - - - -
SP30: -
SP31: - - - - - -
SP32: - - - - - -
SP33:
SP34:
SP35:
SP36:
SP37: - - - - - -
SP38:

ExUns: 38a · 38b ^ 39a · 39b ^ 40a · 40b · 40c ^ 41a · 41b · 41c · 41d ·
SP1:
SP2: - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35: -
SP36:
SP37:
SP38:

Relevant External Links for RGS3 Gene

GeneLoc Exon Structure for
RGS3
ECgene alternative splicing isoforms for
RGS3

Expression for RGS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS3 Gene

Protein differential expression in normal tissues from HIPED for RGS3 Gene

This gene is overexpressed in NK cells (24.7), Peripheral blood mononuclear cells (17.3), and CD8 Tcells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RGS3 Gene



Protein tissue co-expression partners for RGS3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS3 Gene:

RGS3

SOURCE GeneReport for Unigene cluster for RGS3 Gene:

Hs.494875

Evidence on tissue expression from TISSUES for RGS3 Gene

  • Nervous system(4.8)
  • Kidney(4.4)
  • Liver(4.2)
  • Heart(2.5)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with RGS3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS3 Gene

Orthologs for RGS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS3 34 33
  • 99.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RGS3 34 33
  • 87.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RGS3 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs3 33
  • 83.95 (n)
mouse
(Mus musculus)
Mammalia Rgs3 16 34 33
  • 83.52 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS3 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS3 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS3 34 33
  • 73.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS3 34
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-154e10.1 33
  • 59.98 (n)
RGS3 34
  • 41 (a)
OneToOne
Species where no ortholog for RGS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS3 Gene

ENSEMBL:
Gene Tree for RGS3 (if available)
TreeFam:
Gene Tree for RGS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS3: view image

Paralogs for RGS3 Gene

Paralogs for RGS3 Gene

(20) SIMAP similar genes for RGS3 Gene using alignment to 8 proteins:

  • RGS3_HUMAN
  • B3KUB2_HUMAN
  • C9J582_HUMAN
  • C9J6G2_HUMAN
  • H7BXY1_HUMAN
  • H7C539_HUMAN
  • Q5VXC0_HUMAN
  • Q8WVE9_HUMAN
genes like me logo Genes that share paralogs with RGS3: view

Variants for RGS3 Gene

Sequence variations from dbSNP and Humsavar for RGS3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000022701 -- 113,461,905(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000073389 -- 113,588,204(+) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000109750 -- 113,528,911(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000110562 -- 113,556,991(+) A/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000147037 -- 113,458,931(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS3 Gene

Variant ID Type Subtype PubMed ID
dgv12854n54 CNV loss 21841781
esv1750461 CNV deletion 17803354
esv2738955 CNV deletion 23290073
nsv415849 CNV deletion 16902084
nsv466508 CNV loss 19166990
nsv472386 CNV novel sequence insertion 20440878
nsv473478 CNV novel sequence insertion 20440878
nsv478450 CNV novel sequence insertion 20440878
nsv526579 CNV loss 19592680
nsv615215 CNV loss 21841781
nsv950929 CNV deletion 24416366
nsv972443 CNV duplication 23825009

Variation tolerance for RGS3 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS3 Gene

Disorders for RGS3 Gene

Additional Disease Information for RGS3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS3 Gene

Publications for RGS3 Gene

  1. Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. (PMID: 11294858) Shi CS … Kehrl JH (The Journal of biological chemistry 2001) 3 4 22 58
  2. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. (PMID: 10749886) Dulin NO … Dunn MJ (The Journal of biological chemistry 2000) 3 4 22 58
  3. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. (PMID: 9858594) Dulin NO … Dunn MJ (Molecular and cellular biology 1999) 3 4 22 58
  4. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PMID: 8602223) Druey KM … Kehrl JH (Nature 1996) 2 3 4 58
  5. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 44 58

Products for RGS3 Gene

Sources for RGS3 Gene