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Aliases for GPR107 Gene

Aliases for GPR107 Gene

  • G Protein-Coupled Receptor 107 2 3 5
  • Lung Seven Transmembrane Receptor 1 3 4
  • LUSTR1 3 4
  • Protein GPR107 3
  • BA138E2.2 3
  • KIAA1624 4
  • GCDRP 3

External Ids for GPR107 Gene

Previous GeneCards Identifiers for GPR107 Gene

  • GC09P123930
  • GC09P124462
  • GC09P126269
  • GC09P128192
  • GC09P129895
  • GC09P131855
  • GC09P132815
  • GC09P102415

Summaries for GPR107 Gene

GeneCards Summary for GPR107 Gene

GPR107 (G Protein-Coupled Receptor 107) is a Protein Coding gene. An important paralog of this gene is GPR108.

UniProtKB/Swiss-Prot for GPR107 Gene

  • Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.

Gene Wiki entry for GPR107 Gene

Additional gene information for GPR107 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR107 Gene

Genomics for GPR107 Gene

GeneHancer (GH) Regulatory Elements for GPR107 Gene

Promoters and enhancers for GPR107 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J130051 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -0.1 -85 3.5 CLOCK ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 ZNF213 ZNF143 GPR107 FNBP1 TOR1A ENSG00000230684 C9orf78 USP20 TOR1B GC09M130044
GH09J129340 Enhancer 1.3 Ensembl ENCODE dbSUPER 20.5 -712.3 -712259 1.9 CLOCK GLI4 ZNF2 TCF12 ZNF207 ZNF548 ZNF488 ZNF658 ZNF184 NBN SPOUT1 NUP188 LOC101929314 ODF2 URM1 GPR107 LOC101929270 UBE2V1P4 PKN3 GLE1
GH09J130778 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 +727.4 727432 4.9 PKNOX1 ARNT SIN3A FEZF1 ZNF2 BRCA1 YY1 GLIS2 ZNF213 FOS PRRC2B POMT1 FUBP3 GPR107 ABL1 QRFP USP20 GC09P130796 RPL37P17
GH09J129338 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.9 -714.0 -714015 1.3 NFIB SREBF2 NEUROD1 KLF17 ZNF2 TCF12 HSF1 ZNF207 KLF7 ZNF548 NUP188 URM1 SPOUT1 GLE1 LOC101929314 UBE2V1P4 PKN3 GPR107 IER5L LOC105376289
GH09J130241 Enhancer 1.1 Ensembl ENCODE 12 +187.2 187222 0.8 ELF3 FOXA2 ZBTB40 RAD21 YY1 ETS1 ZNF335 ZNF143 RCOR1 FOS FUBP3 GPR107 NCS1 GC09P130226 HMCN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR107 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR107 gene promoter:
  • c-Myc
  • Max
  • POU2F1a
  • POU2F1
  • Hlf
  • C/EBPalpha
  • SRF (504 AA)
  • SRF
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for GPR107 Gene

Genomic Locations for GPR107 Gene
86,744 bases
Plus strand
86,744 bases
Plus strand

Genomic View for GPR107 Gene

Genes around GPR107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR107 Gene

Proteins for GPR107 Gene

  • Protein details for GPR107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein GPR107
    Protein Accession:
    Secondary Accessions:
    • A6NJ53
    • Q2TB81
    • Q5JPA3
    • Q5VW39
    • Q96T26
    • Q9H658
    • Q9HCE8

    Protein attributes for GPR107 Gene

    600 amino acids
    Molecular mass:
    66990 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR107 Gene


neXtProt entry for GPR107 Gene

Post-translational modifications for GPR107 Gene

  • Cleaved by a furin endopeptidase to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.
  • Glycosylation at Asn211, Asn169, and Asn70
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR107 Gene

Domains & Families for GPR107 Gene

Gene Families for GPR107 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR107 Gene


Suggested Antigen Peptide Sequences for GPR107 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LU7TM family.
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR107: view

Function for GPR107 Gene

Molecular function for GPR107 Gene

UniProtKB/Swiss-Prot Function:
Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.

Phenotypes From GWAS Catalog for GPR107 Gene

Gene Ontology (GO) - Molecular Function for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032050 clathrin heavy chain binding IEA --
genes like me logo Genes that share ontologies with GPR107: view
genes like me logo Genes that share phenotypes with GPR107: view

Animal Models for GPR107 Gene

MGI Knock Outs for GPR107:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR107

CRISPR Products

miRNA for GPR107 Gene

miRTarBase miRNAs that target GPR107

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR107

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR107 Gene

Localization for GPR107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR107 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR107 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
plasma membrane 3
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005769 early endosome IEA --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR107: view

Pathways & Interactions for GPR107 Gene

SuperPathways for GPR107 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072583 clathrin-dependent endocytosis IEA --
genes like me logo Genes that share ontologies with GPR107: view

No data available for Pathways by source and SIGNOR curated interactions for GPR107 Gene

Drugs & Compounds for GPR107 Gene

No Compound Related Data Available

Transcripts for GPR107 Gene

Unigene Clusters for GPR107 Gene

G protein-coupled receptor 107:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR107

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP7: -

ExUns: 21a · 21b · 21c

Relevant External Links for GPR107 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR107 Gene

Protein differential expression in normal tissues from HIPED for GPR107 Gene

This gene is overexpressed in Nasal epithelium (55.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPR107 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR107 Gene:


SOURCE GeneReport for Unigene cluster for GPR107 Gene:


Evidence on tissue expression from TISSUES for GPR107 Gene

  • Nervous system(4.9)
  • Intestine(4.4)
  • Lymph node(4.2)
  • Lung(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GPR107: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR107 Gene

Orthologs for GPR107 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR107 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR107 34 33
  • 99.82 (n)
(Bos Taurus)
Mammalia GPR107 34 33
  • 89.53 (n)
(Canis familiaris)
Mammalia GPR107 34 33
  • 89.22 (n)
(Mus musculus)
Mammalia Gpr107 16 34 33
  • 83.4 (n)
(Rattus norvegicus)
Mammalia Gpr107 33
  • 82.75 (n)
(Monodelphis domestica)
Mammalia GPR107 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GPR107 34
  • 77 (a)
(Gallus gallus)
Aves GPR107 34 33
  • 74.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr107 33
  • 66.73 (n)
(Danio rerio)
Actinopterygii gpr107 34 33
  • 66.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12121 34 33
  • 55.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000913 33
  • 54.99 (n)
(Caenorhabditis elegans)
Secernentea C15H9.5 34 33
  • 45.58 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42090 33
  • 51.88 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.380 33
(Oryza sativa)
Liliopsida Os06g0132100 33
  • 49.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
Species where no ortholog for GPR107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR107 Gene

Gene Tree for GPR107 (if available)
Gene Tree for GPR107 (if available)
Evolutionary constrained regions (ECRs) for GPR107: view image

Paralogs for GPR107 Gene

Paralogs for GPR107 Gene

(1) SIMAP similar genes for GPR107 Gene using alignment to 4 proteins:

  • GP107_HUMAN
  • B7ZL93_HUMAN
  • G5E994_HUMAN
genes like me logo Genes that share paralogs with GPR107: view

Variants for GPR107 Gene

Sequence variations from dbSNP and Humsavar for GPR107 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000014147 -- 130,085,167(+) A/G intron_variant
rs1000024941 -- 130,052,890(+) G/A upstream_transcript_variant
rs1000059841 -- 130,131,746(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000132430 -- 130,054,622(+) C/A intron_variant
rs1000141742 -- 130,103,307(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR107 Gene

Variant ID Type Subtype PubMed ID
esv2664800 CNV deletion 23128226
esv3621853 CNV gain 21293372
esv3621854 CNV loss 21293372
nsv1046307 CNV gain 25217958
nsv1141030 CNV deletion 24896259
nsv1141031 CNV deletion 24896259
nsv1153370 CNV insertion 26484159
nsv466590 CNV gain 19166990
nsv474774 CNV novel sequence insertion 20440878
nsv518603 CNV loss 19592680
nsv615498 CNV gain 21841781
nsv6730 CNV insertion 18451855
nsv6732 CNV deletion 18451855
nsv831732 CNV loss 17160897
nsv831733 CNV loss 17160897

Variation tolerance for GPR107 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR107 Gene

Disorders for GPR107 Gene

Additional Disease Information for GPR107

No disorders were found for GPR107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR107 Gene

Publications for GPR107 Gene

  1. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. (PMID: 25031321) Tafesse FG … Ploegh HL (The Journal of biological chemistry 2014) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GPR107 Gene

Sources for GPR107 Gene

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