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Aliases for SEMA4G Gene

Aliases for SEMA4G Gene

  • Semaphorin 4G 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G 2 3
  • Semaphorin-4G 3
  • KIAA1619 4

External Ids for SEMA4G Gene

Previous GeneCards Identifiers for SEMA4G Gene

  • GC10P101625
  • GC10P101966
  • GC10P102860
  • GC10P102396
  • GC10P102719
  • GC10P096361
  • GC10P102729

Summaries for SEMA4G Gene

Entrez Gene Summary for SEMA4G Gene

  • Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SEMA4G Gene

SEMA4G (Semaphorin 4G) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. An important paralog of this gene is SEMA4C.

UniProtKB/Swiss-Prot for SEMA4G Gene

  • Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Gene Wiki entry for SEMA4G Gene

Additional gene information for SEMA4G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4G Gene

Genomics for SEMA4G Gene

GeneHancer (GH) Regulatory Elements for SEMA4G Gene

Promoters and enhancers for SEMA4G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J100968 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 650.7 +1.5 1534 4.5 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 SEMA4G MRPL43 PDZD7 GC10P100975
GH10J100984 Promoter 0.6 EPDnew 650.4 +14.9 14877 0.1 ZBTB17 ENSG00000236662 GC10P100985 PIR34755 SEMA4G MRPL43 MIR608
GH10J100995 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.4 +29.8 29822 7.4 HDGF SMAD1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 LZTS2 PHBP9 ENSG00000231188 TPM4P1 SPCS2P2 MRPL43 DNMBP SEMA4G MIR608 CWF19L1
GH10J100909 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.7 -57.5 -57517 4.8 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000272572 SLF2 MRPL43 TWNK CWF19L1 CHUK POLL PHBP9 SEMA4G MIR608
GH10J101030 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +63.8 63765 6.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS PDZD7 MRPL43 TWNK KAZALD1 TLX1 TLX1NB SEMA4G ENSG00000236662 MIR608 CWF19L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEMA4G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEMA4G gene promoter:
  • HNF-4alpha1
  • RFX1
  • FOXD3
  • CUTL1
  • p53
  • Lmo2
  • FOXO3
  • FOXO3a
  • FOXO3b
  • E47

Genomic Locations for SEMA4G Gene

Genomic Locations for SEMA4G Gene
16,390 bases
Plus strand
16,354 bases
Plus strand

Genomic View for SEMA4G Gene

Genes around SEMA4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4G Gene

Proteins for SEMA4G Gene

  • Protein details for SEMA4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A5C6
    • A6NJY8
    • Q58EY1
    • Q9HCF3

    Protein attributes for SEMA4G Gene

    838 amino acids
    Molecular mass:
    91497 Da
    Quaternary structure:
    • Interacts with PLXNB2.
    • Sequence=BAB13445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA4G Gene


neXtProt entry for SEMA4G Gene

Post-translational modifications for SEMA4G Gene

  • Glycosylation at posLast=598598, posLast=542542, isoforms=2, 3388, posLast=126126, isoforms=2, 3111, and isoforms=2, 355
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEMA4G Gene

Domains & Families for SEMA4G Gene

Gene Families for SEMA4G Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SEMA4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the semaphorin family.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4G: view

Function for SEMA4G Gene

Molecular function for SEMA4G Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Phenotypes From GWAS Catalog for SEMA4G Gene

Gene Ontology (GO) - Molecular Function for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030215 semaphorin receptor binding IBA --
GO:0038191 NOT neuropilin binding IBA --
GO:0045499 chemorepellent activity IBA --
genes like me logo Genes that share ontologies with SEMA4G: view
genes like me logo Genes that share phenotypes with SEMA4G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA4G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA4G Gene

Localization for SEMA4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA4G gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA4G: view

Pathways & Interactions for SEMA4G Gene

genes like me logo Genes that share pathways with SEMA4G: view

Gene Ontology (GO) - Biological Process for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
GO:0030335 positive regulation of cell migration IBA --
genes like me logo Genes that share ontologies with SEMA4G: view

No data available for SIGNOR curated interactions for SEMA4G Gene

Drugs & Compounds for SEMA4G Gene

No Compound Related Data Available

Transcripts for SEMA4G Gene

Unigene Clusters for SEMA4G Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -

Relevant External Links for SEMA4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEMA4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4G Gene

This gene is overexpressed in Colon - Transverse (x7.0) and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for SEMA4G Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEMA4G Gene

Protein tissue co-expression partners for SEMA4G Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMA4G Gene:


SOURCE GeneReport for Unigene cluster for SEMA4G Gene:


Evidence on tissue expression from TISSUES for SEMA4G Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SEMA4G: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMA4G Gene

Orthologs for SEMA4G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEMA4G 34 33
  • 90 (n)
(Canis familiaris)
Mammalia SEMA4G 34 33
  • 89.71 (n)
(Rattus norvegicus)
Mammalia Sema4g 33
  • 88.92 (n)
(Mus musculus)
Mammalia Sema4g 16 34 33
  • 88.56 (n)
(Monodelphis domestica)
Mammalia SEMA4G 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SEMA4G 34
  • 66 (a)
(Gallus gallus)
Aves SEMA4G 34
  • 63 (a)
(Anolis carolinensis)
Reptilia SEMA4G 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4g 33
  • 58.07 (n)
(Danio rerio)
Actinopterygii sema4ga 34 33
  • 56.98 (n)
SEMA4G (2 of 2) 34
  • 48 (a)
Species where no ortholog for SEMA4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4G Gene

Gene Tree for SEMA4G (if available)
Gene Tree for SEMA4G (if available)
Evolutionary constrained regions (ECRs) for SEMA4G: view image

Paralogs for SEMA4G Gene

(15) SIMAP similar genes for SEMA4G Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SEMA4G: view

Variants for SEMA4G Gene

Sequence variations from dbSNP and Humsavar for SEMA4G Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000038219 -- 100,976,030(+) G/A intron_variant
rs1000263318 -- 100,980,496(+) A/G intron_variant
rs1000336668 -- 100,969,778(+) G/A genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000469814 -- 100,986,024(+) G/T downstream_transcript_variant
rs1001397510 -- 100,968,114(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4G Gene

Variant ID Type Subtype PubMed ID
esv3624366 CNV loss 21293372
nsv467443 CNV loss 19166990
nsv517698 CNV loss 19592680
nsv552051 CNV loss 21841781
nsv831965 CNV loss 17160897

Variation tolerance for SEMA4G Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEMA4G Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4G Gene

Disorders for SEMA4G Gene

Additional Disease Information for SEMA4G

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SEMA4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4G Gene

Publications for SEMA4G Gene

  1. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PMID: 19047128) Horikawa Y … Wu X (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 44 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58

Products for SEMA4G Gene

Sources for SEMA4G Gene

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