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Aliases for DPP10 Gene

Aliases for DPP10 Gene

  • Dipeptidyl Peptidase Like 10 2 3 5
  • Dipeptidyl Peptidase IV-Related Protein 3 3 4
  • Dipeptidyl Peptidase-Like Protein 2 3 4
  • Dipeptidyl-Peptidase 10 (Inactive) 2 3
  • Dipeptidyl Peptidase X 3 4
  • DPRP-3 3 4
  • DPP X 3 4
  • DPRP3 3 4
  • DPL2 3 4
  • Dipeptidyl-Peptidase 10 (Non-Functional) 3
  • Inactive Dipeptidyl Peptidase 10 3
  • Dipeptidyl Peptidase 10 3
  • Dipeptidyl-Peptidase 10 2
  • Dipeptidylpeptidase 10 2
  • KIAA1492 4
  • DPPY 3

External Ids for DPP10 Gene

Previous GeneCards Identifiers for DPP10 Gene

  • GC02P115107
  • GC02P116161
  • GC02P115295
  • GC02P114916
  • GC02P115636
  • GC02P107520

Summaries for DPP10 Gene

Entrez Gene Summary for DPP10 Gene

  • This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP10 Gene

DPP10 (Dipeptidyl Peptidase Like 10) is a Protein Coding gene. Diseases associated with DPP10 include Asthma. Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is DPP6.

UniProtKB/Swiss-Prot for DPP10 Gene

  • Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).

Gene Wiki entry for DPP10 Gene

Additional gene information for DPP10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP10 Gene

Genomics for DPP10 Gene

GeneHancer (GH) Regulatory Elements for DPP10 Gene

Promoters and enhancers for DPP10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J115160 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 656.9 +719.3 719275 2.3 SP1 USF1 SUZ12 MAX EZH2 DPP10-AS1 DPP10 GC02P115207
GH02J114442 Promoter 1 EPDnew 650.7 +0.3 332 0.1 ERF ZNF143 NFKBIZ MIXL1 THAP11 KLF11 KLF6 NFIA HLF ZBTB25 DPP10 GC02M114555
GH02J114443 Promoter 0.5 EPDnew 650.7 +0.0 19 0.1 DPP10 GC02M114555
GH02J114444 Enhancer 0.2 FANTOM5 653.5 +1.6 1592 0.4 DPP10 GC02M114555
GH02J114542 Enhancer 0.6 ENCODE 10.3 +101.1 101058 2 GATAD2A CTCF NFIA ZNF384 ZNF644 RAD21 NR2F2 YY1 IKZF5 KDM1A DPP10 GC02M114555
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPP10 gene promoter:
  • Nkx2-5
  • Pbx1a
  • Nkx5-1
  • HFH-3
  • FOXI1
  • S8
  • FOXJ2 (long isoform)
  • FOXJ2
  • HOXA3
  • LHX3b

Genomic Locations for DPP10 Gene

Genomic Locations for DPP10 Gene
1,403,454 bases
Plus strand
1,403,453 bases
Plus strand

Genomic View for DPP10 Gene

Genes around DPP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP10 Gene

Proteins for DPP10 Gene

  • Protein details for DPP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive dipeptidyl peptidase 10
    Protein Accession:
    Secondary Accessions:
    • A8K1Q2
    • J3KPP2
    • J3KQ46
    • Q0GLB8
    • Q53QT3
    • Q53S86
    • Q53SL8
    • Q53SS4
    • Q6TTV4
    • Q86YR9
    • Q9P236

    Protein attributes for DPP10 Gene

    796 amino acids
    Molecular mass:
    90888 Da
    Quaternary structure:
    • May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.
    • Sequence=BAA96016.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DPP10 Gene

    Alternative splice isoforms for DPP10 Gene


neXtProt entry for DPP10 Gene

Post-translational modifications for DPP10 Gene

  • N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.
  • Glycosylation at posLast=760760, posLast=748748, posLast=342342, posLast=257257, posLast=119119, posLast=111111, and posLast=9090
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DPP10 Gene

Domains & Families for DPP10 Gene

Gene Families for DPP10 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S9B family. DPPIV subfamily.
  • Belongs to the peptidase S9B family. DPPIV subfamily.
genes like me logo Genes that share domains with DPP10: view

Function for DPP10 Gene

Molecular function for DPP10 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).

Phenotypes From GWAS Catalog for DPP10 Gene

Gene Ontology (GO) - Molecular Function for DPP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity IEA --
GO:0008239 NOT dipeptidyl-peptidase activity IDA 12662155
GO:0015459 potassium channel regulator activity ISS --
GO:0044325 ion channel binding IPI 27198182
genes like me logo Genes that share ontologies with DPP10: view
genes like me logo Genes that share phenotypes with DPP10: view

Animal Models for DPP10 Gene

MGI Knock Outs for DPP10:
  • Dpp10 Dpp10<tm1.1(NCOM)Mfgc>

Animal Model Products

  • Taconic Biosciences Mouse Models for DPP10

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPP10 Gene

Localization for DPP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP10 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP10 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0008076 voltage-gated potassium channel complex IPI 27198182
GO:0016020 membrane IDA 12662155
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPP10: view

Pathways & Interactions for DPP10 Gene

SuperPathways for DPP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0065009 regulation of molecular function IEA --
GO:0072659 protein localization to plasma membrane ISS --
GO:1901379 regulation of potassium ion transmembrane transport ISS --
GO:1903078 positive regulation of protein localization to plasma membrane IDA 15671030
genes like me logo Genes that share ontologies with DPP10: view

No data available for Pathways by source and SIGNOR curated interactions for DPP10 Gene

Drugs & Compounds for DPP10 Gene

(2) Drugs for DPP10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DPP10: view

Transcripts for DPP10 Gene

mRNA/cDNA for DPP10 Gene

Unigene Clusters for DPP10 Gene

Dipeptidyl-peptidase 10 (non-functional):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - - - - - - -
SP2: - -
SP3: - - - -
SP5: - -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b

Relevant External Links for DPP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPP10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.1), Brain - Anterior cingulate cortex (BA24) (x7.2), Brain - Cortex (x6.1), and Brain - Amygdala (x4.7).

Protein differential expression in normal tissues from HIPED for DPP10 Gene

This gene is overexpressed in Frontal cortex (32.9), Brain (12.7), Pancreas (9.1), Fetal Brain (7.2), and Lung (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPP10 Gene

Protein tissue co-expression partners for DPP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPP10 Gene:


SOURCE GeneReport for Unigene cluster for DPP10 Gene:


mRNA Expression by UniProt/SwissProt for DPP10 Gene:

Tissue specificity: Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.

Evidence on tissue expression from TISSUES for DPP10 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with DPP10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DPP10 Gene

Orthologs for DPP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPP10 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia DPP10 34 33
  • 93.19 (n)
(Bos Taurus)
Mammalia DPP10 34 33
  • 92.88 (n)
(Monodelphis domestica)
Mammalia DPP10 34
  • 89 (a)
(Mus musculus)
Mammalia Dpp10 16 34 33
  • 86.79 (n)
(Rattus norvegicus)
Mammalia Dpp10 33
  • 86.12 (n)
(Ornithorhynchus anatinus)
Mammalia DPP10 34
  • 54 (a)
(Gallus gallus)
Aves DPP10 34 33
  • 80.31 (n)
(Anolis carolinensis)
Reptilia DPP10 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp10 33
  • 69.27 (n)
(Danio rerio)
Actinopterygii LOC101886435 33
  • 54.25 (n)
DPP10 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11319 33
  • 46.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008764 33
  • 46.47 (n)
(Caenorhabditis elegans)
Secernentea dpf-1 33
  • 45.16 (n)
dpf-3 34
  • 15 (a)
Species where no ortholog for DPP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP10 Gene

Gene Tree for DPP10 (if available)
Gene Tree for DPP10 (if available)
Evolutionary constrained regions (ECRs) for DPP10: view image

Paralogs for DPP10 Gene

Paralogs for DPP10 Gene

(3) SIMAP similar genes for DPP10 Gene using alignment to 9 proteins:

  • C9J4M8_HUMAN
  • Q53TB1_HUMAN Pseudogenes for DPP10 Gene

genes like me logo Genes that share paralogs with DPP10: view

Variants for DPP10 Gene

Sequence variations from dbSNP and Humsavar for DPP10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000003080 -- 115,048,166(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000004357 -- 115,693,735(+) A/G intron_variant
rs1000004434 -- 115,179,797(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000006869 -- 114,542,158(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000006930 -- 114,767,794(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPP10 Gene

Variant ID Type Subtype PubMed ID
dgv1166e212 CNV loss 25503493
dgv1167e212 CNV gain 25503493
dgv1998n106 CNV deletion 24896259
dgv1999n106 CNV deletion 24896259
dgv248e215 CNV deletion 23714750
dgv4054n100 CNV loss 25217958
dgv4055n100 CNV loss 25217958
dgv474n27 CNV loss 19166990
dgv7010n54 CNV loss 21841781
dgv7011n54 CNV loss 21841781
dgv7012n54 CNV loss 21841781
dgv7013n54 CNV loss 21841781
dgv7014n54 CNV loss 21841781
dgv7015n54 CNV loss 21841781
dgv7016n54 CNV loss 21841781
dgv7017n54 CNV loss 21841781
dgv7018n54 CNV loss 21841781
dgv733e214 CNV gain 21293372
esv1001957 CNV deletion 20482838
esv1005195 CNV deletion 20482838
esv1031832 CNV deletion 17803354
esv1285088 CNV deletion 17803354
esv1621943 CNV deletion 17803354
esv1920692 CNV deletion 18987734
esv2127128 CNV deletion 18987734
esv21902 CNV loss 19812545
esv2259036 CNV deletion 18987734
esv23278 CNV gain 19812545
esv2421461 CNV deletion 20811451
esv2494215 CNV deletion 19546169
esv2554100 CNV deletion 19546169
esv2601468 CNV deletion 19546169
esv26077 CNV loss 19812545
esv2657725 CNV deletion 23128226
esv2659076 CNV deletion 23128226
esv2660787 CNV deletion 23128226
esv2664172 CNV deletion 23128226
esv2668921 CNV deletion 23128226
esv2720560 CNV deletion 23290073
esv2720562 CNV deletion 23290073
esv2720563 CNV deletion 23290073
esv2720564 CNV deletion 23290073
esv2720565 CNV deletion 23290073
esv2720566 CNV deletion 23290073
esv2720567 CNV deletion 23290073
esv2720568 CNV deletion 23290073
esv2720569 CNV deletion 23290073
esv2720570 CNV deletion 23290073
esv2720571 CNV deletion 23290073
esv2720573 CNV deletion 23290073
esv2720574 CNV deletion 23290073
esv2720575 CNV deletion 23290073
esv2720576 CNV deletion 23290073
esv2720577 CNV deletion 23290073
esv2720578 CNV deletion 23290073
esv2720579 CNV deletion 23290073
esv2759086 CNV gain 17122850
esv2760620 CNV loss 21179565
esv2762794 CNV loss 21179565
esv2763566 CNV loss 21179565
esv2842569 CNV deletion 24192839
esv28528 CNV loss 19812545
esv29876 CNV gain+loss 19812545
esv3304131 CNV mobile element insertion 20981092
esv3304925 CNV mobile element insertion 20981092
esv3308958 CNV mobile element insertion 20981092
esv3326585 CNV insertion 20981092
esv3327527 CNV insertion 20981092
esv3403188 CNV insertion 20981092
esv3406783 CNV insertion 20981092
esv3411106 CNV insertion 20981092
esv35070 CNV gain 17911159
esv3559966 CNV deletion 23714750
esv3559969 CNV deletion 23714750
esv3559972 CNV deletion 23714750
esv3559979 CNV deletion 23714750
esv3559984 CNV deletion 23714750
esv3584030 CNV loss 25503493
esv3584031 CNV loss 25503493
esv3584036 CNV loss 25503493
esv3584039 CNV loss 25503493
esv3592044 CNV loss 21293372
esv3592049 CNV loss 21293372
esv3592050 CNV loss 21293372
esv3592051 CNV loss 21293372
esv3592052 CNV loss 21293372
esv3592053 CNV loss 21293372
esv3592054 CNV loss 21293372
esv3592055 CNV loss 21293372
esv3592057 CNV loss 21293372
esv3592058 CNV loss 21293372
esv3592059 CNV loss 21293372
esv3592060 CNV loss 21293372
esv3592061 CNV loss 21293372
esv3592062 CNV loss 21293372
esv3592064 CNV gain 21293372
esv3592065 CNV gain 21293372
esv3592071 CNV loss 21293372
esv3592072 CNV gain 21293372
esv3893104 CNV gain 25118596
esv3893115 CNV loss 25118596
esv3893126 CNV loss 25118596
esv3893137 CNV gain 25118596
esv3893148 CNV gain 25118596
esv3893159 CNV loss 25118596
esv3893170 CNV loss 25118596
esv3967 CNV loss 18987735
esv5605 CNV gain 19470904
esv5817 CNV loss 19470904
nsv1001709 CNV gain 25217958
nsv1001980 CNV gain 25217958
nsv10134 CNV loss 18304495
nsv10135 CNV gain+loss 18304495
nsv1014859 CNV gain 25217958
nsv1076495 CNV duplication 25765185
nsv1123371 CNV deletion 24896259
nsv1123372 CNV deletion 24896259
nsv1123373 CNV deletion 24896259
nsv1125384 OTHER inversion 24896259
nsv1126561 CNV deletion 24896259
nsv1128809 CNV duplication 24896259
nsv1131498 CNV deletion 24896259
nsv1136304 CNV deletion 24896259
nsv1136397 CNV deletion 24896259
nsv1142280 CNV tandem duplication 24896259
nsv1153232 CNV duplication 26484159
nsv2885 CNV deletion 18451855
nsv437290 CNV loss 16327808
nsv437513 CNV loss 16327808
nsv441776 CNV loss 18776908
nsv442828 CNV loss 18776908
nsv459019 CNV loss 19166990
nsv459052 CNV gain 19166990
nsv470481 CNV loss 18288195
nsv472142 CNV novel sequence insertion 20440878
nsv478452 CNV novel sequence insertion 20440878
nsv511185 CNV loss 21212237
nsv511807 CNV loss 21212237
nsv514085 CNV loss 21397061
nsv514086 CNV loss 21397061
nsv515750 CNV loss 19592680
nsv516975 CNV loss 19592680
nsv520403 CNV loss 19592680
nsv520606 CNV gain 19592680
nsv522754 CNV gain 19592680
nsv522770 CNV loss 19592680
nsv523446 CNV loss 19592680
nsv526317 CNV gain 19592680
nsv526597 CNV loss 19592680
nsv582715 CNV loss 21841781
nsv582717 CNV loss 21841781
nsv582727 CNV loss 21841781
nsv582730 CNV loss 21841781
nsv582731 CNV loss 21841781
nsv582732 CNV loss 21841781
nsv582733 CNV gain 21841781
nsv582736 CNV loss 21841781
nsv582757 CNV gain 21841781
nsv821025 CNV deletion 20802225
nsv829626 CNV loss 20364138
nsv829627 CNV loss 20364138
nsv829628 CNV loss 20364138
nsv829629 CNV gain 20364138
nsv834337 CNV gain 17160897
nsv834338 CNV loss 17160897
nsv834339 CNV gain 17160897
nsv955024 CNV deletion 24416366
nsv955082 CNV deletion 24416366
nsv961498 CNV duplication 23825009

Variation tolerance for DPP10 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPP10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP10 Gene

Disorders for DPP10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPP10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search DPP10 in MalaCards View complete list of genes associated with diseases


  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:14566338, ECO:0000269 PubMed:19237393}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for DPP10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DPP10: view

No data available for Genatlas for DPP10 Gene

Publications for DPP10 Gene

  1. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PMID: 12662155) Qi SY … Akinsanya KO (The Biochemical journal 2003) 2 3 4 22 58
  2. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. (PMID: 19910030) Wu H … London SJ (The Journal of allergy and clinical immunology 2010) 3 22 44 58
  3. A genome-wide association study on African-ancestry populations for asthma. (PMID: 19910028) Mathias RA … Barnes KC (The Journal of allergy and clinical immunology 2010) 3 22 44 58
  4. Polymorphisms of PHF11 and DPP10 are associated with asthma and related traits in a Chinese population. (PMID: 19672052) Gao J … Zhang Y (Respiration; international review of thoracic diseases 2010) 3 22 44 58
  5. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. (PMID: 19237393) Blakey JD … Hall IP (Thorax 2009) 3 4 44 58

Products for DPP10 Gene

Sources for DPP10 Gene

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