Aliases for SHROOM3 Gene
External Ids for SHROOM3 Gene
Previous GeneCards Identifiers for SHROOM3 Gene
This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011]
GeneCards Summary for SHROOM3 Gene
SHROOM3 (Shroom Family Member 3) is a Protein Coding gene. Diseases associated with SHROOM3 include Neutrophil Actin Dysfunction and Atrial Septal Defect 2. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is SHROOM2.
UniProtKB/Swiss-Prot for SHROOM3 Gene
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).