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Aliases for SIPA1L2 Gene

Aliases for SIPA1L2 Gene

  • Signal Induced Proliferation Associated 1 Like 2 2 3 5
  • SIPA1-Like Protein 2 3 4
  • Signal-Induced Proliferation-Associated 1-Like Protein 2 3
  • Signal-Induced Proliferation-Associated 1 Like 2 2
  • SPA-1-Like 2 3
  • KIAA1389 4
  • SPAL2 3

External Ids for SIPA1L2 Gene

Previous GeneCards Identifiers for SIPA1L2 Gene

  • GC01M229617
  • GC01M228840
  • GC01M230600
  • GC01M232533
  • GC01M203022

Summaries for SIPA1L2 Gene

Entrez Gene Summary for SIPA1L2 Gene

  • This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]

GeneCards Summary for SIPA1L2 Gene

SIPA1L2 (Signal Induced Proliferation Associated 1 Like 2) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is SIPA1L1.

Gene Wiki entry for SIPA1L2 Gene

Additional gene information for SIPA1L2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1L2 Gene

Genomics for SIPA1L2 Gene

GeneHancer (GH) Regulatory Elements for SIPA1L2 Gene

Promoters and enhancers for SIPA1L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J232627 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +1.3 1295 4 PKNOX1 ARNT SIN3A GLI4 ZNF2 YY1 ZNF121 GLIS2 FOS KLF13 SIPA1L2 GC01P232625
GH01J232589 Enhancer 0.9 FANTOM5 Ensembl ENCODE 1.5 +40.1 40096 2.4 ZFHX2 ZNF362 PRDM10 EGR2 SIPA1L2 GC01P232625 PIR51388
GH01J232618 Enhancer 1.3 VISTA Ensembl ENCODE 0.4 +9.7 9732 5.6 PKNOX1 SMAD1 FEZF1 GLI4 ZNF2 YY1 ZNF213 ZNF548 ATF7 SP3 RPS7P3 LINC01745 RNU1-74P LINC01744 GC01P232625 SIPA1L2 PIR51388
GH01J232610 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.4 +19.7 19695 1.6 CTCF SOX6 ZBTB8A ZFP69B FOSL1 CTBP1 ZNF766 ZNF692 PRDM10 SPI1 GC01P232625 SIPA1L2 PIR51388
GH01J232599 Enhancer 1.4 FANTOM5 Ensembl ENCODE 0.3 +30.6 30638 1.5 SIN3A FEZF1 ZNF121 ZNF213 ZNF548 ATF7 KLF13 SP3 TSHZ1 ZNF518A RPS7P3 GC01P232625 SIPA1L2 PIR51388
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIPA1L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIPA1L2 gene promoter:
  • Bach1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • GCNF
  • GCNF-1
  • GCNF-2
  • NF-AT

Genomic Locations for SIPA1L2 Gene

Genomic Locations for SIPA1L2 Gene
232,732 bases
Minus strand
163,594 bases
Minus strand

Genomic View for SIPA1L2 Gene

Genes around SIPA1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIPA1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIPA1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1L2 Gene

Proteins for SIPA1L2 Gene

  • Protein details for SIPA1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-induced proliferation-associated 1-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q2TV88
    • Q5VXR7
    • Q5VXR8
    • Q641Q4
    • Q8NA38
    • Q96DZ3
    • Q9H9F6

    Protein attributes for SIPA1L2 Gene

    1722 amino acids
    Molecular mass:
    190438 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92627.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14273.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIPA1L2 Gene


neXtProt entry for SIPA1L2 Gene

Post-translational modifications for SIPA1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SIPA1L2 Gene

Domains & Families for SIPA1L2 Gene

Gene Families for SIPA1L2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SIPA1L2 Gene

Suggested Antigen Peptide Sequences for SIPA1L2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIPA1L2: view

No data available for UniProtKB/Swiss-Prot for SIPA1L2 Gene

Function for SIPA1L2 Gene

Phenotypes From GWAS Catalog for SIPA1L2 Gene

Gene Ontology (GO) - Molecular Function for SIPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SIPA1L2: view
genes like me logo Genes that share phenotypes with SIPA1L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIPA1L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIPA1L2 Gene

Localization for SIPA1L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIPA1L2 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SIPA1L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SIPA1L2 Gene

Pathways & Interactions for SIPA1L2 Gene

SuperPathways for SIPA1L2 Gene

SuperPathway Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with SIPA1L2: view

Pathways by source for SIPA1L2 Gene

1 KEGG pathway for SIPA1L2 Gene

Gene Ontology (GO) - Biological Process for SIPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with SIPA1L2: view

No data available for SIGNOR curated interactions for SIPA1L2 Gene

Drugs & Compounds for SIPA1L2 Gene

No Compound Related Data Available

Transcripts for SIPA1L2 Gene

Unigene Clusters for SIPA1L2 Gene

Signal-induced proliferation-associated 1 like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIPA1L2

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP1: - - -
SP2: - - -
SP3: -
SP4: -

ExUns: 22a · 22b · 22c

Relevant External Links for SIPA1L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIPA1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIPA1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SIPA1L2 Gene

This gene is overexpressed in Fetal Brain (24.9), Adipocyte (19.9), Placenta (7.1), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIPA1L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIPA1L2 Gene:


SOURCE GeneReport for Unigene cluster for SIPA1L2 Gene:


Evidence on tissue expression from TISSUES for SIPA1L2 Gene

  • Nervous system(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SIPA1L2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIPA1L2 Gene

Orthologs for SIPA1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIPA1L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIPA1L2 34 33
  • 99.48 (n)
(Monodelphis domestica)
Mammalia SIPA1L2 34
  • 91 (a)
(Canis familiaris)
Mammalia SIPA1L2 34 33
  • 88.68 (n)
(Bos Taurus)
Mammalia SIPA1L2 34 33
  • 86.2 (n)
(Mus musculus)
Mammalia Sipa1l2 16 34 33
  • 83.2 (n)
(Rattus norvegicus)
Mammalia Sipa1l2 33
  • 82.88 (n)
(Ornithorhynchus anatinus)
Mammalia SIPA1L2 34
  • 63 (a)
(Gallus gallus)
Aves SIPA1L2 34 33
  • 77.93 (n)
(Anolis carolinensis)
Reptilia SIPA1L2 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1l2 33
  • 68.55 (n)
Str.20345 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19940 33
(Danio rerio)
Actinopterygii SIPA1L2 (2 of 2) 34
  • 76 (a)
im:7137555 33
  • 64.75 (n)
SIPA1L2 (1 of 2) 34
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008488 33
  • 55.91 (n)
Species where no ortholog for SIPA1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1L2 Gene

Gene Tree for SIPA1L2 (if available)
Gene Tree for SIPA1L2 (if available)
Evolutionary constrained regions (ECRs) for SIPA1L2: view image

Paralogs for SIPA1L2 Gene

(3) SIMAP similar genes for SIPA1L2 Gene using alignment to 2 proteins:

  • A7E2F9_HUMAN
genes like me logo Genes that share paralogs with SIPA1L2: view

Variants for SIPA1L2 Gene

Sequence variations from dbSNP and Humsavar for SIPA1L2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000001614 -- 232,614,768(-) G/ genic_upstream_transcript_variant, intron_variant
rs1000006790 -- 232,447,231(-) T/C intron_variant
rs1000016017 -- 232,573,904(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000035190 -- 232,447,424(-) A/C intron_variant
rs1000056111 -- 232,569,168(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIPA1L2 Gene

Variant ID Type Subtype PubMed ID
dgv154e212 CNV loss 25503493
dgv583n100 CNV gain 25217958
esv1056324 CNV insertion 17803354
esv2666130 CNV deletion 23128226
esv2724961 CNV deletion 23290073
esv2724972 CNV deletion 23290073
esv2724983 CNV deletion 23290073
esv2750829 CNV gain 17911159
esv3352928 CNV insertion 20981092
esv3578473 CNV loss 25503493
esv3589134 CNV loss 21293372
esv3589135 CNV loss 21293372
esv994086 CNV insertion 20482838
nsv1006763 CNV gain 25217958
nsv549355 CNV gain 21841781
nsv820068 CNV loss 19587683

Variation tolerance for SIPA1L2 Gene

Residual Variation Intolerance Score: 2.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.50; 88.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIPA1L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1L2 Gene

Disorders for SIPA1L2 Gene

Additional Disease Information for SIPA1L2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SIPA1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIPA1L2 Gene

Publications for SIPA1L2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58

Products for SIPA1L2 Gene

Sources for SIPA1L2 Gene

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