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Aliases for PTK7 Gene

Aliases for PTK7 Gene

  • Protein Tyrosine Kinase 7 (Inactive) 2 3 5
  • Colon Carcinoma Kinase 4 2 3 4
  • Pseudo Tyrosine Kinase Receptor 7 3 4
  • PTK7 Protein Tyrosine Kinase 7 2 3
  • Tyrosine-Protein Kinase-Like 7 3 4
  • CCK-4 3 4
  • CCK4 3 4
  • Inactive Tyrosine-Protein Kinase 7 3
  • Protein Tyrosine Kinase 7 2
  • Protein-Tyrosine Kinase 7 4

External Ids for PTK7 Gene

Previous GeneCards Identifiers for PTK7 Gene

  • GC06P043046
  • GC06P043090
  • GC06P043153
  • GC06P042761

Summaries for PTK7 Gene

Entrez Gene Summary for PTK7 Gene

  • This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PTK7 Gene

PTK7 (Protein Tyrosine Kinase 7 (Inactive)) is a Protein Coding gene. Diseases associated with PTK7 include Panic Disorder and Agoraphobia. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ROS1.

UniProtKB/Swiss-Prot for PTK7 Gene

  • Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Gene Wiki entry for PTK7 Gene

Additional gene information for PTK7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTK7 Gene

Genomics for PTK7 Gene

GeneHancer (GH) Regulatory Elements for PTK7 Gene

Promoters and enhancers for PTK7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I043073 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 566 6.3 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ETS1 SLC30A9 ZNF121 PTK7 CUL7 DNPH1 ENSG00000272170 PIR51341 KLC4
GH06I042780 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 18.8 -292.2 -292176 7.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B LOC401261 CUL7 ABCC10 BICRAL ZNF318 GTPBP2 RPL24P4 POLR1C POLH RPL34P14
GH06I043087 Enhancer 1.4 Ensembl ENCODE dbSUPER 22.8 +14.9 14933 7.3 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B FEZF1 ZNF213 SP5 NFYC ZNF318 ABCC10 CUL7 RPS2P29 POLH POLR1C XPO5 GTPBP2 BICRAL ENSG00000271970
GH06I043509 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 +434.3 434282 2.3 ATF1 ARID4B SIN3A ZNF2 ZNF48 YY1 POLR2B GLIS2 ZNF207 ZNF143 POLR1C LRRC73 ABCC10 CUL7 ZNF318 RPS2P29 ENSG00000272223 XPO5 RPL34P14 PTK7
GH06I043810 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.2 +736.3 736326 5.8 HDGF PKNOX1 FOXA2 FEZF1 ZNF2 ZNF302 ZNF548 KLF13 SP3 REST ZNF318 GTPBP2 POLH ABCC10 RPS2P29 RRP36 ENSG00000271970 RPL34P14 POLR1C PTK7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTK7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTK7 gene promoter:

Genomic Locations for PTK7 Gene

Genomic Locations for PTK7 Gene
chr6:43,076,268-43,161,720
(GRCh38/hg38)
Size:
85,453 bases
Orientation:
Plus strand
chr6:43,044,006-43,129,457
(GRCh37/hg19)

Genomic View for PTK7 Gene

Genes around PTK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTK7 Gene

Proteins for PTK7 Gene

  • Protein details for PTK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13308-PTK7_HUMAN
    Recommended name:
    Inactive tyrosine-protein kinase 7
    Protein Accession:
    Q13308
    Secondary Accessions:
    • A8K974
    • B7Z477
    • E9PFZ5
    • Q13417
    • Q5T650
    • Q6IQ54
    • Q8NFA5
    • Q8NFA6
    • Q8NFA7
    • Q8NFA8

    Protein attributes for PTK7 Gene

    Size:
    1070 amino acids
    Molecular mass:
    118392 Da
    Quaternary structure:
    • Interacts with CTNNB1.

    Alternative splice isoforms for PTK7 Gene

neXtProt entry for PTK7 Gene

Post-translational modifications for PTK7 Gene

  • MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
  • Glycosylation at isoforms=2, 3, 4, 5, 6116, Asn175, isoforms=2, 3, 4, 5, 6184, Asn214, Asn268, Asn283, Asn405, isoforms=2, 4, 5, 6463, Asn567, and Asn646

No data available for DME Specific Peptides for PTK7 Gene

Domains & Families for PTK7 Gene

Gene Families for PTK7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PTK7 Gene

Graphical View of Domain Structure for InterPro Entry

Q13308

UniProtKB/Swiss-Prot:

PTK7_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with PTK7: view

Function for PTK7 Gene

Molecular function for PTK7 Gene

GENATLAS Biochemistry:
protein tyrosine kinase 7,expressed in K-562,human leukemia cell and liver
UniProtKB/Swiss-Prot Function:
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
UniProtKB/Swiss-Prot Induction:
Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines established from highly metastatic invasive carcinomas (at protein level).

Phenotypes From GWAS Catalog for PTK7 Gene

Gene Ontology (GO) - Molecular Function for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 21132015
GO:0005524 ATP binding IEA --
GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway IEA,NAS 24431302
genes like me logo Genes that share ontologies with PTK7: view
genes like me logo Genes that share phenotypes with PTK7: view

Animal Model Products

Clone Products

  • Addgene plasmids for PTK7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTK7 Gene

Localization for PTK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTK7 Gene

Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTK7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0005911 cell-cell junction IDA,IEA 20837484
GO:0005925 focal adhesion HDA,IDA 21423176
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTK7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTK7 Gene

Pathways & Interactions for PTK7 Gene

genes like me logo Genes that share pathways with PTK7: view

SIGNOR curated interactions for PTK7 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001736 establishment of planar polarity IEA --
GO:0001843 neural tube closure IEA --
GO:0003281 ventricular septum development IEA --
GO:0003401 axis elongation IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PTK7: view

Drugs & Compounds for PTK7 Gene

(15) Drugs for PTK7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(6) Additional Compounds for PTK7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PTK7: view

Transcripts for PTK7 Gene

Unigene Clusters for PTK7 Gene

Protein tyrosine kinase 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for PTK7

Alternative Splicing Database (ASD) splice patterns (SP) for PTK7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10:
SP11: - - - - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 16a · 16b · 16c · 16d ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8:
SP9: - - - - -
SP10: - -
SP11: - - - - -
SP12:
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - - -
SP16: -
SP17:
SP18:
SP19: - -

Relevant External Links for PTK7 Gene

GeneLoc Exon Structure for
PTK7
ECgene alternative splicing isoforms for
PTK7

Expression for PTK7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTK7 Gene

mRNA differential expression in normal tissues according to GTEx for PTK7 Gene

This gene is overexpressed in Uterus (x5.4) and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for PTK7 Gene

This gene is overexpressed in Uterus (18.2), Fetal ovary (9.0), and Ovary (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTK7 Gene



NURSA nuclear receptor signaling pathways regulating expression of PTK7 Gene:

PTK7

SOURCE GeneReport for Unigene cluster for PTK7 Gene:

Hs.90572

mRNA Expression by UniProt/SwissProt for PTK7 Gene:

Q13308-PTK7_HUMAN
Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

Evidence on tissue expression from TISSUES for PTK7 Gene

  • Liver(4.2)
  • Nervous system(3.4)
  • Heart(2.2)
  • Gall bladder(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with PTK7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTK7 Gene

Orthologs for PTK7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTK7 33 34
  • 98.97 (n)
cow
(Bos Taurus)
Mammalia PTK7 33 34
  • 89.51 (n)
dog
(Canis familiaris)
Mammalia PTK7 33 34
  • 89.48 (n)
mouse
(Mus musculus)
Mammalia Ptk7 33 16 34
  • 87.79 (n)
oppossum
(Monodelphis domestica)
Mammalia PTK7 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTK7 33 34
  • 69.3 (n)
lizard
(Anolis carolinensis)
Reptilia PTK7 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487595 33
  • 70.31 (n)
zebrafish
(Danio rerio)
Actinopterygii ptk7b 33
  • 62.28 (n)
ptk7a 34
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011489 33
  • 49.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta otk 35 33 34
  • 47.45 (n)
CG8964 35 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for PTK7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTK7 Gene

ENSEMBL:
Gene Tree for PTK7 (if available)
TreeFam:
Gene Tree for PTK7 (if available)

Paralogs for PTK7 Gene

Paralogs for PTK7 Gene

genes like me logo Genes that share paralogs with PTK7: view

Variants for PTK7 Gene

Sequence variations from dbSNP and Humsavar for PTK7 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_041508 A colorectal adenocarcinoma sample p.Ala933Val
rs1000016969 -- 43,114,906(+) G/T intron_variant
rs1000026213 -- 43,116,936(+) G/C intron_variant
rs1000078234 -- 43,146,834(+) A/G intron_variant
rs1000088647 -- 43,115,248(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTK7 Gene

Variant ID Type Subtype PubMed ID
dgv10640n54 CNV loss 21841781
esv3571027 CNV loss 25503493
nsv1017398 CNV gain 25217958
nsv437509 CNV loss 16327808
nsv462927 CNV loss 19166990
nsv462930 CNV loss 19166990
nsv462932 CNV loss 19166990
nsv521730 CNV loss 19592680
nsv602992 CNV loss 21841781
nsv602996 CNV loss 21841781
nsv950169 CNV deletion 24416366

Variation tolerance for PTK7 Gene

Residual Variation Intolerance Score: 4.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTK7 Gene

Human Gene Mutation Database (HGMD)
PTK7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTK7 Gene

Disorders for PTK7 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTK7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
panic disorder
  • panic anxiety syndrome
agoraphobia
  • fear of open spaces
anxiety
  • anxiety disorder
phobic disorder
  • phobic anxiety disorder
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search PTK7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTK7

genes like me logo Genes that share disorders with PTK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTK7 Gene

Publications for PTK7 Gene

  1. Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. (PMID: 7478540) Mossie K … Ullrich A (Oncogene 1995) 2 3 4 22 58
  2. Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA. (PMID: 12427550) Jung JW … Lee ST (Biochimica et biophysica acta 2002) 3 4 22 58
  3. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. (PMID: 8882711) Park SK … Lee ST (Journal of biochemistry 1996) 3 4 22 58
  4. Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling. (PMID: 21132015) Puppo F … Borg JP (EMBO reports 2011) 3 4 58
  5. Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway. (PMID: 21103379) Meng L … Tan W (PloS one 2010) 3 4 58

Products for PTK7 Gene

Sources for PTK7 Gene