Aliases for PELI1 Gene
External Ids for PELI1 Gene
Previous GeneCards Identifiers for PELI1 Gene
GeneCards Summary for PELI1 Gene
PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PELI2.
UniProtKB/Swiss-Prot for PELI1 Gene
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates Lys-63-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.