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Aliases for SLURP1 Gene

Aliases for SLURP1 Gene

  • Secreted LY6/PLAUR Domain Containing 1 2 3 5
  • Lymphocyte Antigen 6-Like Secreted 2 3
  • Anti-Neoplastic Urinary Protein 3 4
  • ARS(Component B)-81/S 3 4
  • ARS Component B 2 4
  • SLURP-1 3 4
  • ANUP 3 4
  • ARS 3 4
  • Secreted Ly-6/UPAR-Related Protein 1 3
  • Secreted Ly6/UPAR Related Protein 1 3
  • LY6LS 3
  • ArsB 3
  • MDM 3

External Ids for SLURP1 Gene

Previous GeneCards Identifiers for SLURP1 Gene

  • GC08M143820
  • GC08M139075

Summaries for SLURP1 Gene

Entrez Gene Summary for SLURP1 Gene

  • The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLURP1 Gene

SLURP1 (Secreted LY6/PLAUR Domain Containing 1) is a Protein Coding gene. Diseases associated with SLURP1 include Mal De Meleda and Palmoplantar Keratoderma, Norrbotten Recessive Type. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is LYPD2.

UniProtKB/Swiss-Prot for SLURP1 Gene

  • Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).

Gene Wiki entry for SLURP1 Gene

Additional gene information for SLURP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLURP1 Gene

Genomics for SLURP1 Gene

GeneHancer (GH) Regulatory Elements for SLURP1 Gene

Promoters and enhancers for SLURP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J142740 Enhancer 0.8 ENCODE 650.7 +1.3 1283 1 ELF3 ARID4B DNMT3B ZNF48 ZSCAN9 RAD21 ZNF614 CREM THAP11 RXRA SLURP1 LY6K PIR37820
GH08J142742 Promoter 0.7 EPDnew 664.7 0.0 -15 0.1 ZNF687 DPF2 SLURP1 LY6K LYPD2
GH08J142667 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11 +72.5 72471 5.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 E2F8 JRK PSCA LY6K ZNF623 SLURP1 ZC3H3 C8orf31 ENSG00000255050 PIR47130
GH08J142674 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.9 +62.7 62660 11 HDGF CLOCK ATF1 NEUROD1 SIN3A ZBTB7B TCF12 GLIS2 ZNF143 FOS PSCA JRK LY6K THEM6 SLURP1
GH08J142698 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 12.8 +42.4 42378 3.2 ARNT INSM2 KLF17 SIN3A FEZF1 ZNF2 ZEB1 ZNF335 GLIS2 ZNF213 LY6K PIR40452 THEM6 SLURP1 PSCA LYPD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLURP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLURP1 gene promoter:
  • p53
  • Nkx2-5
  • AP-2gamma
  • C/EBPalpha
  • Tal-1beta
  • ITF-2
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for SLURP1 Gene

Genomic Locations for SLURP1 Gene
chr8:142,740,944-142,742,411
(GRCh38/hg38)
Size:
1,468 bases
Orientation:
Minus strand
chr8:143,822,362-143,823,829
(GRCh37/hg19)
Size:
1,468 bases
Orientation:
Minus strand

Genomic View for SLURP1 Gene

Genes around SLURP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLURP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLURP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLURP1 Gene

Proteins for SLURP1 Gene

  • Protein details for SLURP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55000-SLUR1_HUMAN
    Recommended name:
    Secreted Ly-6/uPAR-related protein 1
    Protein Accession:
    P55000
    Secondary Accessions:
    • Q53YJ6
    • Q6PUA6
    • Q92483

    Protein attributes for SLURP1 Gene

    Size:
    103 amino acids
    Molecular mass:
    11186 Da
    Quaternary structure:
    • Homodimer. Interacts with PLAU (PubMed:25168896). Interacts with CHRNA7 (PubMed:26905431).

    Three dimensional structures from OCA and Proteopedia for SLURP1 Gene

neXtProt entry for SLURP1 Gene

Post-translational modifications for SLURP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLURP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLURP1 Gene

Domains & Families for SLURP1 Gene

Gene Families for SLURP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SLURP1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLURP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SLURP1: view

No data available for UniProtKB/Swiss-Prot for SLURP1 Gene

Function for SLURP1 Gene

Molecular function for SLURP1 Gene

UniProtKB/Swiss-Prot Function:
Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).
UniProtKB/Swiss-Prot Induction:
Regulated by retinoic acid, EGF and IFNG/IFN-gamma (PubMed:14721776). Down-regulated by IL-13 in cultured human bronchial epithelial cells (related to asthmatic condition) (PubMed:20621062).

Phenotypes From GWAS Catalog for SLURP1 Gene

Gene Ontology (GO) - Molecular Function for SLURP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 8742060
GO:0005515 protein binding IPI 26905431
GO:0030549 acetylcholine receptor activator activity IDA 14506129
genes like me logo Genes that share ontologies with SLURP1: view
genes like me logo Genes that share phenotypes with SLURP1: view

Human Phenotype Ontology for SLURP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLURP1 Gene

MGI Knock Outs for SLURP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLURP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SLURP1 Gene

Localization for SLURP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLURP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLURP1 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLURP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 8742060
GO:0005615 extracellular space IDA,IEA 25919322
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with SLURP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLURP1 Gene

Pathways & Interactions for SLURP1 Gene

SuperPathways for SLURP1 Gene

No Data Available

Interacting Proteins for SLURP1 Gene

Gene Ontology (GO) - Biological Process for SLURP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001775 cell activation NAS 11285253
GO:0007155 cell adhesion TAS 14506129
GO:0007626 locomotory behavior IEA --
GO:0008285 negative regulation of cell proliferation IDA,IEA 25168896
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with SLURP1: view

No data available for Pathways by source and SIGNOR curated interactions for SLURP1 Gene

Drugs & Compounds for SLURP1 Gene

(2) Drugs for SLURP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SLURP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLURP1: view

Transcripts for SLURP1 Gene

mRNA/cDNA for SLURP1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLURP1 Gene

Secreted LY6/PLAUR domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLURP1 Gene

No ASD Table

Relevant External Links for SLURP1 Gene

GeneLoc Exon Structure for
SLURP1
ECgene alternative splicing isoforms for
SLURP1

Expression for SLURP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLURP1 Gene

mRNA differential expression in normal tissues according to GTEx for SLURP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.6), Skin - Sun Exposed (Lower leg) (x16.8), and Skin - Not Sun Exposed (Suprapubic) (x11.0).

Protein differential expression in normal tissues from HIPED for SLURP1 Gene

This gene is overexpressed in Cervix (34.0) and Urine (33.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLURP1 Gene



Protein tissue co-expression partners for SLURP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLURP1 Gene:

SLURP1

SOURCE GeneReport for Unigene cluster for SLURP1 Gene:

Hs.103505

mRNA Expression by UniProt/SwissProt for SLURP1 Gene:

P55000-SLUR1_HUMAN
Tissue specificity: Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.

Evidence on tissue expression from TISSUES for SLURP1 Gene

  • Skin(4.6)
  • Blood(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLURP1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • skeleton
Regions:
Head and neck:
  • head
  • mouth
  • skull
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • skin
  • sweat gland
genes like me logo Genes that share expression patterns with SLURP1: view

Orthologs for SLURP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLURP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLURP1 34 33
  • 99.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLURP1 34 33
  • 82.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slurp1 33
  • 79.21 (n)
dog
(Canis familiaris)
Mammalia SLURP1 34 33
  • 79.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slurp1 16 34 33
  • 77.67 (n)
oppossum
(Monodelphis domestica)
Mammalia SLURP1 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLURP1 34
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLURP1 34
  • 34 (a)
OneToOne
Species where no ortholog for SLURP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLURP1 Gene

ENSEMBL:
Gene Tree for SLURP1 (if available)
TreeFam:
Gene Tree for SLURP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLURP1: view image

Paralogs for SLURP1 Gene

Paralogs for SLURP1 Gene

(1) SIMAP similar genes for SLURP1 Gene using alignment to 1 proteins:

  • SLUR1_HUMAN
genes like me logo Genes that share paralogs with SLURP1: view

Variants for SLURP1 Gene

Sequence variations from dbSNP and Humsavar for SLURP1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs121908317 pathogenic, Acroerythrokeratoderma 142,741,169(-) G/A/C coding_sequence_variant, missense_variant, stop_gained
rs121908318 pathogenic, Acroerythrokeratoderma, Mal de Meleda (MDM) [MIM:248300] 142,742,343(-) A/G coding_sequence_variant, missense_variant
rs121908319 pathogenic, Acroerythrokeratoderma, Mal de Meleda (MDM) [MIM:248300] 142,741,226(-) A/G coding_sequence_variant, missense_variant
rs121908320 pathogenic, Acroerythrokeratoderma, Mal de Meleda (MDM) [MIM:248300] 142,741,159(-) C/T coding_sequence_variant, missense_variant
rs182887603 uncertain-significance, Acroerythrokeratoderma 142,741,000(-) C/G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SLURP1 Gene

Variant ID Type Subtype PubMed ID
esv2661137 CNV deletion 23128226
esv2737925 CNV deletion 23290073
nsv1023021 CNV loss 25217958
nsv1125022 CNV duplication 24896259
nsv831485 CNV loss 17160897
nsv831486 CNV gain 17160897
nsv950004 CNV deletion 24416366

Variation tolerance for SLURP1 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLURP1 Gene

Human Gene Mutation Database (HGMD)
SLURP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLURP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLURP1 Gene

Disorders for SLURP1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SLURP1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mal de meleda
  • mdm
palmoplantar keratoderma, norrbotten recessive type
  • ppknr
palmoplantar keratosis
  • keratosis palmaris et plantaris
prostate carcinoma in situ
  • carcinoma in situ of prostate
keratosis
  • actinic keratosis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SLUR1_HUMAN
  • Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. {ECO:0000269 PubMed:11285253, ECO:0000269 PubMed:12483299, ECO:0000269 PubMed:12950349, ECO:0000269 PubMed:14756676, ECO:0000269 PubMed:17008884, ECO:0000269 PubMed:19120323, ECO:0000269 PubMed:21690549, ECO:0000269 PubMed:24604124, ECO:0000269 PubMed:25919322}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLURP1

genes like me logo Genes that share disorders with SLURP1: view

No data available for Genatlas for SLURP1 Gene

Publications for SLURP1 Gene

  1. Mutations in the gene encoding SLURP-1 in Mal de Meleda. (PMID: 11285253) Fischer J … Prud'homme JF (Human molecular genetics 2001) 2 3 4 22 58
  2. Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. (PMID: 10211827) Adermann K … Nehls M (Protein science : a publication of the Protein Society 1999) 2 3 4 22 58
  3. Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. (PMID: 12483299) Eckl KM … Hennies HC (Human genetics 2003) 3 4 22 58
  4. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. (PMID: 14506129) Chimienti F … Hohl D (Human molecular genetics 2003) 3 4 22 58
  5. ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. (PMID: 14721776) Mastrangeli R … Papoian R (European journal of dermatology : EJD 2003) 3 4 22 58

Products for SLURP1 Gene

Sources for SLURP1 Gene

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