Aliases for SLURP1 Gene
External Ids for SLURP1 Gene
Previous GeneCards Identifiers for SLURP1 Gene
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLURP1 Gene
SLURP1 (Secreted LY6/PLAUR Domain Containing 1) is a Protein Coding gene. Diseases associated with SLURP1 include Mal De Meleda and Palmoplantar Keratoderma, Norrbotten Recessive Type. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is LYPD2.
UniProtKB/Swiss-Prot for SLURP1 Gene
Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).