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Aliases for DDX24 Gene

Aliases for DDX24 Gene

  • DEAD-Box Helicase 24 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 24 2
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 24 2
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 24 2
  • DEAD Box Protein 24 4
  • EC 4
  • EC 3.6.1 56

External Ids for DDX24 Gene

Previous GeneCards Identifiers for DDX24 Gene

  • GC14M092024
  • GC14M088333
  • GC14M092507
  • GC14M093587
  • GC14M094517
  • GC14M074697

Summaries for DDX24 Gene

Entrez Gene Summary for DDX24 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX24 Gene

DDX24 (DEAD-Box Helicase 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX24 Gene

  • ATP-dependent RNA helicase.

Gene Wiki entry for DDX24 Gene

Additional gene information for DDX24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX24 Gene

Genomics for DDX24 Gene

GeneHancer (GH) Regulatory Elements for DDX24 Gene

Promoters and enhancers for DDX24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I094079 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.4 +0.3 255 3.3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 POLR2B GLIS2 DDX24 IFI27L1 PIR58882 BTBD7 IFI27 PPP4R4
GH14I094025 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.2 +53.2 53230 4.1 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B IRF4 ZNF207 ZNF548 FOS OTUB2 BTBD7 DDX24 CCDC197 ASB2 IFI27L2 IFI27L1 IFI27 GC14M094051 GC14M094050
GH14I094065 Enhancer 1.1 Ensembl ENCODE 23.9 +15.0 14981 1.6 FOXA2 NFIB ZNF133 KLF17 ZNF195 FEZF1 ZNF2 RARA ZNF335 GLIS2 DDX24 BTBD7 IFI27 PIR58882 GC14M094051 GC14M094050
GH14I094173 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -93.5 -93525 2.9 INSM2 ARID4B KLF17 MZF1 ZNF76 SIN3A BMI1 FEZF1 ZNF335 GLIS2 PPP4R4 IFI27L2 IFI27L1 DDX24 LOC105370634 GC14M094218
GH14I094109 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11.1 -29.6 -29567 2.8 KLF17 RFX5 ZNF766 CREM CAVIN1 ZNF592 MEF2D NFIC GLIS1 IKZF1 IFI27 IFI27L1 DDX24 IFI27L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DDX24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX24 gene promoter:

Genomic Locations for DDX24 Gene

Genomic Locations for DDX24 Gene
32,955 bases
Minus strand

Genomic View for DDX24 Gene

Genes around DDX24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX24 Gene

Proteins for DDX24 Gene

  • Protein details for DDX24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX24
    Protein Accession:
    Secondary Accessions:
    • E7EMJ4
    • Q4V9L5

    Protein attributes for DDX24 Gene

    859 amino acids
    Molecular mass:
    96332 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX24 Gene


neXtProt entry for DDX24 Gene

Selected DME Specific Peptides for DDX24 Gene


Post-translational modifications for DDX24 Gene

  • Ubiquitination at Lys195, Lys429, posLast=541541, and Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX24 Gene

Domains & Families for DDX24 Gene

Gene Families for DDX24 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
genes like me logo Genes that share domains with DDX24: view

Function for DDX24 Gene

Molecular function for DDX24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase.

Enzyme Numbers (IUBMB) for DDX24 Gene

Phenotypes From GWAS Catalog for DDX24 Gene

Gene Ontology (GO) - Molecular Function for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003724 RNA helicase activity NAS 10936056
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX24: view
genes like me logo Genes that share phenotypes with DDX24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX24

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX24 Gene

Localization for DDX24 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX24 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with DDX24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX24 Gene

Pathways & Interactions for DDX24 Gene

SuperPathways for DDX24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
GO:0016070 RNA metabolic process NAS 10936056
genes like me logo Genes that share ontologies with DDX24: view

No data available for Pathways by source and SIGNOR curated interactions for DDX24 Gene

Drugs & Compounds for DDX24 Gene

(3) Drugs for DDX24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for DDX24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX24: view

Transcripts for DDX24 Gene

Unigene Clusters for DDX24 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP4: - -
SP6: -
SP7: -

Relevant External Links for DDX24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.7) and Tlymphocyte (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX24 Gene

Protein tissue co-expression partners for DDX24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX24 Gene:


SOURCE GeneReport for Unigene cluster for DDX24 Gene:


mRNA Expression by UniProt/SwissProt for DDX24 Gene:

Tissue specificity: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.

Evidence on tissue expression from TISSUES for DDX24 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Intestine(4.6)
  • Lung(4)
  • Pancreas(3.6)
  • Skin(3.5)
  • Kidney(3.1)
  • Eye(2.9)
  • Stomach(2.9)
  • Heart(2.5)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with DDX24: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX24 Gene

Orthologs for DDX24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX24 33 34
  • 99.26 (n)
(Bos Taurus)
Mammalia DDX24 33 34
  • 86.76 (n)
(Canis familiaris)
Mammalia DDX24 33 34
  • 85.56 (n)
(Rattus norvegicus)
Mammalia Ddx24 33
  • 82.25 (n)
(Mus musculus)
Mammalia Ddx24 33 16 34
  • 81.75 (n)
(Monodelphis domestica)
Mammalia DDX24 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia DDX24 34
  • 60 (a)
(Gallus gallus)
Aves DDX24 33 34
  • 63.01 (n)
(Anolis carolinensis)
Reptilia DDX24 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx24 33
  • 60.35 (n)
Str.14965 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398446 33
(Danio rerio)
Actinopterygii LOC553462 33
  • 62.3 (n)
ddx24 34
  • 48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2533 33
fruit fly
(Drosophila melanogaster)
Insecta CG9143 35 33 34
  • 57.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010702 33
  • 51.33 (n)
(Caenorhabditis elegans)
Secernentea F55F8.2 33 34
  • 50.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK5 34 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3498 34
  • 41 (a)
Species where no ortholog for DDX24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX24 Gene

Gene Tree for DDX24 (if available)
Gene Tree for DDX24 (if available)

Paralogs for DDX24 Gene

(4) SIMAP similar genes for DDX24 Gene using alignment to 3 proteins: Pseudogenes for DDX24 Gene

genes like me logo Genes that share paralogs with DDX24: view

No data available for Paralogs for DDX24 Gene

Variants for DDX24 Gene

Sequence variations from dbSNP and Humsavar for DDX24 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000081904 -- 94,074,053(-) A/G intron_variant
rs1000147075 -- 94,075,352(-) C/T intron_variant
rs1000176612 -- 94,058,424(-) C/T intron_variant
rs1000202291 -- 94,068,628(-) A/G intron_variant
rs1000250016 -- 94,079,754(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX24 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV loss 18971310
esv3581391 CNV loss 25503493
esv3635373 CNV gain 21293372

Variation tolerance for DDX24 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX24 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX24 Gene

Disorders for DDX24 Gene

Additional Disease Information for DDX24

No disorders were found for DDX24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX24 Gene

Publications for DDX24 Gene

  1. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. (PMID: 10936056) Zhao Y … Zhao S (Genomics 2000) 2 3 4 58
  2. The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. (PMID: 18289627) Ma J … Liang C (Virology 2008) 2 3 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for DDX24 Gene

Sources for DDX24 Gene

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