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Aliases for PCBP4 Gene

Aliases for PCBP4 Gene

  • Poly(RC) Binding Protein 4 2 3 5
  • Poly(RC)-Binding Protein 4 2 3
  • RNA Binding Protein MCG10 2 3
  • LYST-Interacting Protein 2 3
  • Alpha-CP4 3 4
  • AlphaCP-4 Protein 2
  • MCG10 3
  • LIP4 3
  • CBP 3

External Ids for PCBP4 Gene

Previous GeneCards Identifiers for PCBP4 Gene

  • GC03M051084
  • GC03M051245
  • GC03M051848
  • GC03M051950
  • GC03M051967

Summaries for PCBP4 Gene

Entrez Gene Summary for PCBP4 Gene

  • This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP4 Gene

PCBP4 (Poly(RC) Binding Protein 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for PCBP4 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Gene Wiki entry for PCBP4 Gene

Additional gene information for PCBP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP4 Gene

Genomics for PCBP4 Gene

GeneHancer (GH) Regulatory Elements for PCBP4 Gene

Promoters and enhancers for PCBP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J051973 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 650.7 -1.1 -1093 3.8 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 SP3 SP5 ABHD14A ABHD14A-ACY1 ENSG00000272762 PCBP4 ABHD14B PARP3 NT5DC2 ACY1
GH03J051966 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.4 +6.1 6066 3.8 HDGF RB1 ARID4B ZNF335 TCF12 EGR1 SCRT2 EGR2 PAF1 ZNF398 PCBP4 ABHD14B LOC101929054 PARP3 ABHD14A GC03P051963 ENSG00000272762
GH03J052044 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -77.6 -77606 14 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416 DUSP7 DCAF1 GPR62 RAD54L2 PHF7 NT5DC2 RPL29 PCBP4 WDR82 SFMBT1
GH03J052153 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -180.4 -180449 2.6 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B POC1A RRP9 RAD54L2 PBRM1 RFT1 DUSP7 ABHD14A-ACY1 ABHD14B PCBP4 ACY1
GH03J052040 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 -66.0 -66037 1.1 FOXA2 DMAP1 RARA CREM THAP11 SP5 RXRA CEBPB NFYC MIER2 GPR62 RPL29 PCBP4 LOC105377088 DUSP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCBP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PCBP4 gene promoter:
  • NRSF form 1
  • NRSF form 2
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for PCBP4 Gene

Genomic Locations for PCBP4 Gene
chr3:51,957,454-51,974,016
(GRCh38/hg38)
Size:
16,563 bases
Orientation:
Minus strand
chr3:51,991,470-52,002,426
(GRCh37/hg19)
Size:
10,957 bases
Orientation:
Minus strand

Genomic View for PCBP4 Gene

Genes around PCBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP4 Gene

Proteins for PCBP4 Gene

  • Protein details for PCBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57723-PCBP4_HUMAN
    Recommended name:
    Poly(rC)-binding protein 4
    Protein Accession:
    P57723
    Secondary Accessions:
    • Q96AH7

    Protein attributes for PCBP4 Gene

    Size:
    403 amino acids
    Molecular mass:
    41482 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCBP4 Gene

Post-translational modifications for PCBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCBP4 Gene

Domains & Families for PCBP4 Gene

Gene Families for PCBP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PCBP4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCBP4: view

No data available for UniProtKB/Swiss-Prot for PCBP4 Gene

Function for PCBP4 Gene

Molecular function for PCBP4 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Phenotypes From GWAS Catalog for PCBP4 Gene

Gene Ontology (GO) - Molecular Function for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding NAS 10936052
GO:0003730 mRNA 3-UTR binding IDA 20817677
genes like me logo Genes that share ontologies with PCBP4: view
genes like me logo Genes that share phenotypes with PCBP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCBP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCBP4 Gene

Localization for PCBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCBP4 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PCBP4: view

Pathways & Interactions for PCBP4 Gene

genes like me logo Genes that share pathways with PCBP4: view

Pathways by source for PCBP4 Gene

Gene Ontology (GO) - Biological Process for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0043488 regulation of mRNA stability IDA 20817677
genes like me logo Genes that share ontologies with PCBP4: view

No data available for SIGNOR curated interactions for PCBP4 Gene

Drugs & Compounds for PCBP4 Gene

No Compound Related Data Available

Transcripts for PCBP4 Gene

mRNA/cDNA for PCBP4 Gene

Unigene Clusters for PCBP4 Gene

Poly(rC) binding protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCBP4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^
SP1:
SP2:
SP3:
SP4: - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: - - - -
SP10: - -
SP11:
SP12: - - -
SP13: -
SP14: - - - -
SP15: - - -
SP16: - -
SP17: - -

ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1:
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PCBP4 Gene

GeneLoc Exon Structure for
PCBP4
ECgene alternative splicing isoforms for
PCBP4

Expression for PCBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCBP4 Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for PCBP4 Gene

This gene is overexpressed in Retina (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCBP4 Gene



Protein tissue co-expression partners for PCBP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCBP4 Gene:

PCBP4

SOURCE GeneReport for Unigene cluster for PCBP4 Gene:

Hs.20930

Evidence on tissue expression from TISSUES for PCBP4 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Eye(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PCBP4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCBP4 Gene

Orthologs for PCBP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PCBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCBP4 33
  • 99.67 (n)
-- 34
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
OneToMany
PCBP4 33
  • 93.05 (n)
cow
(Bos Taurus)
Mammalia PCBP4 34 33
  • 92.8 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Pcbp4 16 34 33
  • 92.06 (n)
rat
(Rattus norvegicus)
Mammalia Pcbp4 33
  • 92.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 80 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:65870 33
  • 66.24 (n)
PCBP4 34
  • 55 (a)
OneToMany
wufc68f03 33
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL018C 33
  • 46.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 33
  • 42.15 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10703g 33
  • 41.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09237 33
  • 49.25 (n)
Species where no ortholog for PCBP4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP4 Gene

ENSEMBL:
Gene Tree for PCBP4 (if available)
TreeFam:
Gene Tree for PCBP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCBP4: view image

Paralogs for PCBP4 Gene

Paralogs for PCBP4 Gene

(5) SIMAP similar genes for PCBP4 Gene using alignment to 12 proteins:

  • PCBP4_HUMAN
  • B3KM64_HUMAN
  • C9IZV9_HUMAN
  • C9J0A4_HUMAN
  • C9J5V4_HUMAN
  • C9J7A9_HUMAN
  • C9JTY5_HUMAN
  • C9JZY3_HUMAN
  • C9K0A2_HUMAN
  • F8WC71_HUMAN
  • Q9GZT1_HUMAN
  • Q9HCU2_HUMAN
genes like me logo Genes that share paralogs with PCBP4: view

Variants for PCBP4 Gene

Sequence variations from dbSNP and Humsavar for PCBP4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000387144 -- 51,962,201(-) T/C intron_variant
rs1000596514 -- 51,966,673(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000651797 -- 51,957,116(-) G/T downstream_transcript_variant
rs1000663011 -- 51,959,748(-) G/A intron_variant
rs1000814477 -- 51,963,546(-) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PCBP4 Gene

Variant ID Type Subtype PubMed ID
esv3365586 CNV duplication 20981092
nsv1003453 CNV gain 25217958
nsv1073642 CNV deletion 25765185
nsv508922 CNV insertion 20534489
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366

Variation tolerance for PCBP4 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCBP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCBP4 Gene

Disorders for PCBP4 Gene

Additional Disease Information for PCBP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PCBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP4 Gene

Publications for PCBP4 Gene

  1. Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. (PMID: 10936052) Makeyev AV … Liebhaber SA (Genomics 2000) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer. (PMID: 15205328) Pio R … Montuenga LM (Cancer research 2004) 3 22 58

Products for PCBP4 Gene

Sources for PCBP4 Gene

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