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Aliases for KIF15 Gene

Aliases for KIF15 Gene

  • Kinesin Family Member 15 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-62 3 4
  • Kinesin-Like Protein 2 3 4
  • Kinesin-Like Protein 7 3 4
  • Kinesin-Like 7 2 3
  • HKLP2 3 4
  • KNSL7 3 4
  • KLP2 3 4
  • Kinesin-Like Protein KIF15 3
  • NY-BR-62 3

External Ids for KIF15 Gene

Previous HGNC Symbols for KIF15 Gene

  • KNSL7

Previous GeneCards Identifiers for KIF15 Gene

  • GC03P044779
  • GC03P044803
  • GC03P044804
  • GC03P044838
  • GC03P044846
  • GC03P044943
  • GC03P044987
  • GC03P045026
  • GC03P045062

Summaries for KIF15 Gene

GeneCards Summary for KIF15 Gene

KIF15 (Kinesin Family Member 15) is a Protein Coding gene. Diseases associated with KIF15 include Thrombocytopenia Robin Sequence and Breast Cancer. Among its related pathways are Golgi-to-ER retrograde transport and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is CENPE.

UniProtKB/Swiss-Prot for KIF15 Gene

  • Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.

Additional gene information for KIF15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF15 Gene

Genomics for KIF15 Gene

GeneHancer (GH) Regulatory Elements for KIF15 Gene

Promoters and enhancers for KIF15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J044760 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.3 339 2.5 MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D RCOR2 KIAA1143 KIF15 ZNF852 RN7SL145P HNRNPA1P77
GH03J044685 Promoter/Enhancer 1.3 Ensembl ENCODE 11.2 -76.1 -76114 1.2 HDGF PKNOX1 RB1 BMI1 ZBTB40 E4F1 ETS1 PHF20 POLR2A ZNF207 LOC101928592 ENSG00000236869 ZNF35 ZNF197 ZNF502 KIAA1143 ZNF852 KIF15 ZNF501 ZNF660
GH03J044860 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 0.1 +100.3 100269 2.1 ARID4B DMAP1 ZNF48 YY1 ZNF121 GLIS2 ZNF207 ZNF143 FOS RUNX3 TMEM42 GC03P045106 MIR564 GC03P045107 ZNF502 PPIAP18 KIF15
GH03J044825 Enhancer 0.4 ENCODE 0.2 +64.1 64080 0.2 RCOR1 FOS SPI1 ZNF197-AS1 ZNF197 HNRNPA1P77 KIF15
GH03J044845 Enhancer 0.4 ENCODE 0.2 +84.1 84070 0.2 POLR2A RCOR1 CHD2 HNRNPA1P77 TGM4 ZNF197 ZNF660 TMEM42 KIF15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF15 gene promoter:
  • IRF-1
  • YY1
  • FOXO1a
  • FOXO1
  • Pax-6
  • HNF-1A
  • HNF-1
  • En-1
  • RFX1
  • Nkx6-1

Genomic Locations for KIF15 Gene

Genomic Locations for KIF15 Gene
chr3:44,761,714-44,873,376
(GRCh38/hg38)
Size:
111,663 bases
Orientation:
Plus strand
chr3:44,803,209-44,914,868
(GRCh37/hg19)
Size:
111,660 bases
Orientation:
Plus strand

Genomic View for KIF15 Gene

Genes around KIF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF15 Gene

Proteins for KIF15 Gene

  • Protein details for KIF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS87-KIF15_HUMAN
    Recommended name:
    Kinesin-like protein KIF15
    Protein Accession:
    Q9NS87
    Secondary Accessions:
    • Q17RV9
    • Q69YL6
    • Q96JX7
    • Q9H280

    Protein attributes for KIF15 Gene

    Size:
    1388 amino acids
    Molecular mass:
    160160 Da
    Quaternary structure:
    • Interacts with MKI67 and TPX2.
    SequenceCaution:
    • Sequence=AAG48261.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF15 Gene

    Alternative splice isoforms for KIF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF15 Gene

Post-translational modifications for KIF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF15 Gene

Domains & Families for KIF15 Gene

Gene Families for KIF15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIF15 Gene

Suggested Antigen Peptide Sequences for KIF15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS87

UniProtKB/Swiss-Prot:

KIF15_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.
genes like me logo Genes that share domains with KIF15: view

Function for KIF15 Gene

Molecular function for KIF15 Gene

UniProtKB/Swiss-Prot Function:
Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.

Phenotypes From GWAS Catalog for KIF15 Gene

Gene Ontology (GO) - Molecular Function for KIF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10878014
GO:0003774 motor activity TAS 10878014
GO:0003777 microtubule motor activity IEA,IBA --
GO:0005515 protein binding IPI 10878014
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF15: view
genes like me logo Genes that share phenotypes with KIF15: view

Animal Model Products

miRNA for KIF15 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF15 Gene

Localization for KIF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF15 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF15 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome TAS 10878014
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF15 Gene

Pathways & Interactions for KIF15 Gene

genes like me logo Genes that share pathways with KIF15: view

Gene Ontology (GO) - Biological Process for KIF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 10878014
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS,IEA --
GO:0008283 cell proliferation TAS 10878014
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with KIF15: view

No data available for SIGNOR curated interactions for KIF15 Gene

Drugs & Compounds for KIF15 Gene

(2) Drugs for KIF15 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Kif15-IN-1 Pharma 0
Kif15-IN-2 Pharma 0
genes like me logo Genes that share compounds with KIF15: view

Transcripts for KIF15 Gene

Unigene Clusters for KIF15 Gene

Kinesin family member 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF15 Gene

No ASD Table

Relevant External Links for KIF15 Gene

GeneLoc Exon Structure for
KIF15
ECgene alternative splicing isoforms for
KIF15

Expression for KIF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF15 Gene

This gene is overexpressed in Testis (x9.9).

Protein differential expression in normal tissues from HIPED for KIF15 Gene

This gene is overexpressed in Heart (23.9), Lung (23.1), and Urine (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF15 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF15 Gene:

KIF15

SOURCE GeneReport for Unigene cluster for KIF15 Gene:

Hs.658939

mRNA Expression by UniProt/SwissProt for KIF15 Gene:

Q9NS87-KIF15_HUMAN
Tissue specificity: Expressed in testis, colon, thymus and in breast cancer.

Evidence on tissue expression from TISSUES for KIF15 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with KIF15: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF15 Gene

Orthologs for KIF15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF15 34 33
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIF15 34 33
  • 89.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIF15 34 33
  • 88.94 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kif15 16 34 33
  • 85.61 (n)
rat
(Rattus norvegicus)
Mammalia Kif15 33
  • 85.08 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF15 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF15 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF15 34 33
  • 70.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF15 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487512 33
  • 65.28 (n)
Str.17744 33
African clawed frog
(Xenopus laevis)
Amphibia klp2 33
zebrafish
(Danio rerio)
Actinopterygii kif15 34 33
  • 56.36 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea klp-10 34
  • 32 (a)
OneToMany
klp-18 34
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN8 34
  • 22 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.2413 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToOne
Species where no ortholog for KIF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF15 Gene

ENSEMBL:
Gene Tree for KIF15 (if available)
TreeFam:
Gene Tree for KIF15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF15: view image

Paralogs for KIF15 Gene

(6) SIMAP similar genes for KIF15 Gene using alignment to 6 proteins:

  • KIF15_HUMAN
  • C9JKA9_HUMAN
  • D6RCT7_HUMAN
  • F8WC33_HUMAN
  • H7BZT2_HUMAN
  • H7C1K7_HUMAN

Pseudogenes.org Pseudogenes for KIF15 Gene

genes like me logo Genes that share paralogs with KIF15: view

Variants for KIF15 Gene

Sequence variations from dbSNP and Humsavar for KIF15 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000034324 -- 44,806,321(+) A/G intron_variant
rs1000061986 -- 44,790,130(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000066467 -- 44,794,026(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000090556 -- 44,808,569(+) T/C intron_variant
rs1000091888 -- 44,813,541(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF15 Gene

Variant ID Type Subtype PubMed ID
esv3596039 CNV loss 21293372
nsv3791 CNV insertion 18451855
nsv3792 CNV deletion 18451855
nsv822071 CNV loss 20364138
nsv834675 CNV gain 17160897
nsv967011 CNV duplication 23825009

Variation tolerance for KIF15 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF15 Gene

Human Gene Mutation Database (HGMD)
KIF15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF15 Gene

Disorders for KIF15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIF15 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
thrombocytopenia robin sequence
  • braddock carey syndrome
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search KIF15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF15

genes like me logo Genes that share disorders with KIF15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF15 Gene

Publications for KIF15 Gene

  1. The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2. (PMID: 10878014) Sueishi M … Yoneda Y (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Kif15 cooperates with eg5 to promote bipolar spindle assembly. (PMID: 19818618) Tanenbaum ME … Medema RH (Current biology : CB 2009) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan MJ … Old LJ (Cancer immunity 2001) 3 4 58
  5. Loss-of-Function Mutations in KIF15 Underlying a Braddock-Carey Genocopy. (PMID: 28150392) Sleiman PMA … Hakonarson H (Human mutation 2017) 3 58

Products for KIF15 Gene

Sources for KIF15 Gene

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