Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PYY Gene

Aliases for PYY Gene

  • Peptide YY 2 3 3 5
  • Peptide Tyrosine Tyrosine 3 4
  • Prepro-PYY 2 3
  • PYY-I 3 4
  • PYY1 3

External Ids for PYY Gene

Previous GeneCards Identifiers for PYY Gene

  • GC17M041772
  • GC17M044207
  • GC17M042040
  • GC17M042505
  • GC17M039385
  • GC17M037794

Summaries for PYY Gene

Entrez Gene Summary for PYY Gene

  • This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]

GeneCards Summary for PYY Gene

PYY (Peptide YY) is a Protein Coding gene. Diseases associated with PYY include Anorexia Nervosa and Bulimia Nervosa. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is NPY.

UniProtKB/Swiss-Prot for PYY Gene

  • This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Gene Wiki entry for PYY Gene

Additional gene information for PYY Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYY Gene

Genomics for PYY Gene

GeneHancer (GH) Regulatory Elements for PYY Gene

Promoters and enhancers for PYY Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J044003 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 +17.9 17948 5 HDGF PKNOX1 ZFP64 ARID4B SIN3A YY1 ZNF213 ZNF143 KLF13 PAF1 NAGS PYY NBR1 G6PC3 TMEM101 PIR35856 GC17P043983
GH17J043953 Promoter/Enhancer 0.7 EPDnew ENCODE 661.8 +70.3 70274 0.1 PYY NAGS ENSG00000221044 PPY GC17P043983
GH17J043982 Promoter 0.6 EPDnew 650.3 +41.7 41663 0.1 ZNF18 GC17P043983 PYY PPY TMEM101 MPP2 ENSG00000221044
GH17J044024 Enhancer 0.4 FANTOM5 650.7 -0.2 -204 0.4 KLF9 RCOR1 PYY TMEM101 ENSG00000221044 CFAP97D1 LSM12 NAGS CD300LG GC17P043983
GH17J044023 Enhancer 0.3 FANTOM5 650.7 +0.9 945 0.3 TMEM101 PYY ENSG00000221044 PIR35856 GC17P043983
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PYY on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PYY gene promoter:
  • Sp1
  • YY1
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for PYY Gene

Genomic Locations for PYY Gene
71,528 bases
Minus strand
51,732 bases
Minus strand

Genomic View for PYY Gene

Genes around PYY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYY Gene

Proteins for PYY Gene

  • Protein details for PYY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptide YY
    Protein Accession:
    Secondary Accessions:
    • Q5U5Q6
    • Q6FGH8

    Protein attributes for PYY Gene

    97 amino acids
    Molecular mass:
    11145 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PYY Gene

    Alternative splice isoforms for PYY Gene


neXtProt entry for PYY Gene

Post-translational modifications for PYY Gene

  • The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).

Other Protein References for PYY Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PYY Gene

Domains & Families for PYY Gene

Gene Families for PYY Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PYY Gene

Suggested Antigen Peptide Sequences for PYY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NPY family.
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PYY: view

Function for PYY Gene

Molecular function for PYY Gene

UniProtKB/Swiss-Prot Function:
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
GENATLAS Biochemistry:
peptide YY,gut hormone,inhibiting exocrine pancreatic secretion

Phenotypes From GWAS Catalog for PYY Gene

Gene Ontology (GO) - Molecular Function for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 7493937
GO:0005179 hormone activity TAS 10698177
GO:0005184 neuropeptide hormone activity IBA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with PYY: view
genes like me logo Genes that share phenotypes with PYY: view

Animal Models for PYY Gene

MGI Knock Outs for PYY:
  • Pyy Pyy<tm1.1Batt>
  • Pyy Pyy<tm1Mws>
  • Pyy Pyy<tm1Able>

Animal Model Products

  • Taconic Biosciences Mouse Models for PYY

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PYY

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PYY Gene

Localization for PYY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYY Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYY gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
plasma membrane 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with PYY: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PYY Gene

Pathways & Interactions for PYY Gene

genes like me logo Genes that share pathways with PYY: view

SIGNOR curated interactions for PYY Gene


Gene Ontology (GO) - Biological Process for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
GO:0007631 feeding behavior TAS 10698177
GO:0008283 cell proliferation TAS 10488139
genes like me logo Genes that share ontologies with PYY: view

Drugs & Compounds for PYY Gene

(78) Drugs for PYY Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrocortisone Approved, Vet_approved Pharma Agonist 713
Insulin Detemir Approved Pharma 214
Insulin Glargine Approved Pharma 557
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 594
Zinc Approved, Investigational Pharma 2430

(24) Additional Compounds for PYY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PYY: view

Transcripts for PYY Gene

mRNA/cDNA for PYY Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYY Gene

Peptide YY:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PYY

Alternative Splicing Database (ASD) splice patterns (SP) for PYY Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b

Relevant External Links for PYY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PYY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYY Gene

This gene is overexpressed in Colon - Transverse (x31.7), Small Intestine - Terminal Ileum (x13.7), and Colon - Sigmoid (x4.0).

Protein differential expression in normal tissues from HIPED for PYY Gene

This gene is overexpressed in Colon (42.1) and Rectum (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PYY Gene

Protein tissue co-expression partners for PYY Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PYY Gene:


SOURCE GeneReport for Unigene cluster for PYY Gene:


Evidence on tissue expression from TISSUES for PYY Gene

  • Intestine(4.7)
  • Nervous system(4.6)
  • Stomach(2.7)
  • Blood(2.6)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with PYY: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PYY Gene

Orthologs for PYY Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PYY 34 33
  • 96.91 (n)
(Canis familiaris)
Mammalia PYY 34 33
  • 84.54 (n)
(Bos Taurus)
Mammalia PYY 34 33
  • 80.76 (n)
(Rattus norvegicus)
Mammalia Pyy 33
  • 80.07 (n)
(Mus musculus)
Mammalia Pyy 16 34 33
  • 77.32 (n)
(Monodelphis domestica)
Mammalia PYY 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia PYY 34
  • 54 (a)
(Gallus gallus)
Aves PPY 34
  • 34 (a)
(Anolis carolinensis)
Reptilia PYY 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pyy 33
  • 53.33 (n)
(Danio rerio)
Actinopterygii pyya 33
  • 58.42 (n)
pyyb 34
  • 41 (a)
Species where no ortholog for PYY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYY Gene

Gene Tree for PYY (if available)
Gene Tree for PYY (if available)
Evolutionary constrained regions (ECRs) for PYY: view image

Paralogs for PYY Gene

Paralogs for PYY Gene

(4) SIMAP similar genes for PYY Gene using alignment to 1 proteins:

  • PYY_HUMAN Pseudogenes for PYY Gene

genes like me logo Genes that share paralogs with PYY: view

Variants for PYY Gene

Sequence variations from dbSNP and Humsavar for PYY Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs104894604 pathogenic, Hyperammonemia, type III 44,006,584(-) G/A genic_upstream_transcript_variant, intron_variant
rs104894605 pathogenic, Hyperammonemia, type III 44,007,611(-) T/C genic_upstream_transcript_variant, intron_variant
rs104894606 pathogenic, Hyperammonemia, type III 44,007,772(-) T/C/G genic_upstream_transcript_variant, intron_variant
rs104894607 pathogenic, Hyperammonemia, type III 44,007,621(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs113134544 likely-benign, benign, not specified, Hyperammonemia, type III, not provided 44,004,845(-) A/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PYY Gene

Variant ID Type Subtype PubMed ID
esv2675215 CNV deletion 23128226
nsv112219 CNV insertion 16902084
nsv1125242 CNV deletion 24896259
nsv1129188 CNV insertion 24896259
nsv1142218 CNV tandem duplication 24896259
nsv1146669 OTHER inversion 26484159
nsv1152253 CNV insertion 26484159
nsv833454 CNV loss 17160897

Variation tolerance for PYY Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PYY Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYY Gene

Disorders for PYY Gene

MalaCards: The human disease database

(20) MalaCards diseases for PYY Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anorexia nervosa
  • anorexia nervosa, susceptibility to
bulimia nervosa
  • bulimia nervosa, susceptibility to
eating disorder
  • eating disorders
short bowel syndrome
  • acquired short bowel syndrome
dumping syndrome
  • dumping syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PYY in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PYY

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PYY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYY Gene

Publications for PYY Gene

  1. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Peptide YY levels across pubertal stages and associations with growth hormone. (PMID: 20375207) Lloyd B … Misra M (The Journal of clinical endocrinology and metabolism 2010) 3 22 58
  5. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PMID: 20642810) Friedlander Y … Siscovick DS (Annals of human genetics 2010) 3 44 58

Products for PYY Gene

Sources for PYY Gene

Loading form....