Aliases for MEPE Gene
External Ids for MEPE Gene
Previous GeneCards Identifiers for MEPE Gene
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for MEPE Gene
MEPE (Matrix Extracellular Phosphoglycoprotein) is a Protein Coding gene. Diseases associated with MEPE include Hypophosphatemic Rickets, Autosomal Dominant and Hypophosphatemic Rickets, X-Linked Recessive. Among its related pathways are ERK Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent.
UniProtKB/Swiss-Prot for MEPE Gene
Promotes renal phosphate excretion and modulates mineralization.