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Aliases for DUSP22 Gene

Aliases for DUSP22 Gene

  • Dual Specificity Phosphatase 22 2 3 5
  • Low Molecular Weight Dual Specificity Phosphatase 2 3 4
  • Mitogen-Activated Protein Kinase Phosphatase X 3 4
  • JNK-Stimulatory Phosphatase-1 3 4
  • MAP Kinase Phosphatase X 3 4
  • LMW-DSP2 3 4
  • LMWDSP2 3 4
  • JSP-1 3 4
  • MKP-X 3 4
  • JSP1 3 4
  • MKPX 3 4
  • Homolog Of Mouse Dual Specificity Phosphatase LMW-DSP2 3
  • Dual Specificity Protein Phosphatase 22 3
  • JNK-Stimulating Phosphatase 1 3
  • EC 4
  • EC 4
  • JKAP 3
  • VHX 3

External Ids for DUSP22 Gene

Previous GeneCards Identifiers for DUSP22 Gene

  • GC06P000282
  • GC06P000237
  • GC06P000197

Summaries for DUSP22 Gene

GeneCards Summary for DUSP22 Gene

DUSP22 (Dual Specificity Phosphatase 22) is a Protein Coding gene. Diseases associated with DUSP22 include Alk-Negative Anaplastic Large Cell Lymphoma and Lymphatic System Cancer. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

UniProtKB/Swiss-Prot for DUSP22 Gene

  • Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).

Gene Wiki entry for DUSP22 Gene

Additional gene information for DUSP22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP22 Gene

Genomics for DUSP22 Gene

GeneHancer (GH) Regulatory Elements for DUSP22 Gene

Promoters and enhancers for DUSP22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J000290 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 654.2 +3.4 3396 10 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A DMAP1 YBX1 DUSP22 EXOC2 CICP18 IRF4 LOC102723922 GC06P000310
GH06J000390 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.3 +101.1 101051 3.6 HDGF PKNOX1 SMAD1 RB1 KLF17 STAT5A KLF5 IRF4 ZNF335 ZNF366 IRF4 CICP18 ENSG00000205653 DUSP22 EXOC2 GC06P000406
GH06J000256 Enhancer 1.1 FANTOM5 Ensembl dbSUPER 6.7 -34.1 -34143 1 SOX13 HLF JUNB CEBPB EBF1 ATF2 NFIL3 CEBPA EED IKZF1 ENSG00000205653 DUSP22 GC06M000261 LOC105374870
GH06J000234 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.4 -55.7 -55711 2.2 HDGF PKNOX1 SMAD1 YBX1 BATF IRF4 RAD21 ZNF48 ZNF366 ZNF143 ENSG00000205653 IRF4 DUSP22 LOC105374870 GC06M000261
GH06J000286 Enhancer 0.9 ENCODE dbSUPER 4.9 -4.4 -4432 1.4 HDGF EBF1 IRF4 RELA POLR2A EED ZNF143 ATF7 BCLAF1 RNF2 DUSP22 LOC102723922 GC06M000261
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP22 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • RelA

Genomic Locations for DUSP22 Gene

Genomic Locations for DUSP22 Gene
59,726 bases
Plus strand
59,726 bases
Plus strand

Genomic View for DUSP22 Gene

Genes around DUSP22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP22 Gene

Proteins for DUSP22 Gene

  • Protein details for DUSP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 22
    Protein Accession:
    Secondary Accessions:
    • B4DK56
    • Q59GW2
    • Q5VWR2
    • Q96AR1

    Protein attributes for DUSP22 Gene

    184 amino acids
    Molecular mass:
    20910 Da
    Quaternary structure:
    • Monomer.
    • Sequence=AAH16844.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP22 Gene

    Alternative splice isoforms for DUSP22 Gene


neXtProt entry for DUSP22 Gene

Post-translational modifications for DUSP22 Gene

  • Myristoylation regulates subcellular location, and is necessary for activation of JNK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUSP22 Gene

Domains & Families for DUSP22 Gene

Gene Families for DUSP22 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP22: view

Function for DUSP22 Gene

Molecular function for DUSP22 Gene

UniProtKB/Swiss-Prot Function:
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUSP22 Gene

Phenotypes From GWAS Catalog for DUSP22 Gene

Gene Ontology (GO) - Molecular Function for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP22: view
genes like me logo Genes that share phenotypes with DUSP22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP22

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP22 Gene

Localization for DUSP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP22 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP22 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with DUSP22: view

Pathways & Interactions for DUSP22 Gene

SuperPathways for DUSP22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 16636663
GO:0000188 inactivation of MAPK activity TAS 9205128
GO:0002710 negative regulation of T cell mediated immunity IEA --
GO:0006470 protein dephosphorylation TAS 9205128
GO:0006915 apoptotic process TAS 9205128
genes like me logo Genes that share ontologies with DUSP22: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP22 Gene

Drugs & Compounds for DUSP22 Gene

(2) Drugs for DUSP22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with DUSP22: view

Transcripts for DUSP22 Gene

Unigene Clusters for DUSP22 Gene

Dual specificity phosphatase 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP22 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - - - - - -

Relevant External Links for DUSP22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP22 Gene

This gene is overexpressed in Pancreatic juice (33.7), Peripheral blood mononuclear cells (12.8), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP22 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP22 Gene:


SOURCE GeneReport for Unigene cluster for DUSP22 Gene:


mRNA Expression by UniProt/SwissProt for DUSP22 Gene:

Tissue specificity: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.

Evidence on tissue expression from TISSUES for DUSP22 Gene

  • Nervous system(4.7)
  • Blood(4.4)
  • Lung(4.3)
  • Lymph node(4.3)
  • Spleen(4.3)
  • Pancreas(4.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with DUSP22: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP22 Gene

Orthologs for DUSP22 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP22 34 33
  • 99.19 (n)
(Ornithorhynchus anatinus)
Mammalia DUSP22 34
  • 92 (a)
(Canis familiaris)
Mammalia DUSP22 34 33
  • 89.48 (n)
(Rattus norvegicus)
Mammalia Dusp22 33
  • 88.82 (n)
(Mus musculus)
Mammalia Dusp22 16 34 33
  • 87.32 (n)
(Bos Taurus)
Mammalia DUSP22 34 33
  • 83.74 (n)
(Monodelphis domestica)
Mammalia DUSP22 34
  • 68 (a)
(Gallus gallus)
Aves DUSP22 34 33
  • 74.96 (n)
(Anolis carolinensis)
Reptilia DUSP22 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp22 33
  • 69.11 (n)
(Danio rerio)
Actinopterygii dusp22b 34 33
  • 65.38 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.830 33
fruit fly
(Drosophila melanogaster)
Insecta CG10089 34 33
  • 57.66 (n)
(Caenorhabditis elegans)
Secernentea C16A3.2 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9033 34
  • 40 (a)
Species where no ortholog for DUSP22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP22 Gene

Gene Tree for DUSP22 (if available)
Gene Tree for DUSP22 (if available)
Evolutionary constrained regions (ECRs) for DUSP22: view image

Paralogs for DUSP22 Gene

(15) SIMAP similar genes for DUSP22 Gene using alignment to 6 proteins:

  • S4R378_HUMAN
  • S4R3A4_HUMAN
  • S4R3K1_HUMAN
  • S4R3M1_HUMAN
  • S4R459_HUMAN
genes like me logo Genes that share paralogs with DUSP22: view

Variants for DUSP22 Gene

Sequence variations from dbSNP and Humsavar for DUSP22 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000062330 -- 312,302(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000103756 -- 316,298(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000104604 -- 329,925(+) T/G downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000133317 -- 340,918(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000139367 -- 308,912(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP22 Gene

Variant ID Type Subtype PubMed ID
dgv10257n54 CNV gain 21841781
dgv10260n54 CNV loss 21841781
dgv10261n54 CNV loss 21841781
dgv10263n54 CNV loss 21841781
dgv10264n54 CNV loss 21841781
dgv10265n54 CNV loss 21841781
dgv10266n54 CNV loss 21841781
dgv1157e214 CNV gain 21293372
dgv1158e214 CNV gain 21293372
dgv1159e214 CNV gain 21293372
dgv140e203 CNV gain+loss 21179565
dgv1693e212 CNV loss 25503493
dgv1694e212 CNV gain 25503493
dgv1695e212 CNV gain 25503493
dgv1696e212 CNV gain 25503493
dgv1698e212 CNV loss 25503493
dgv1699e212 CNV gain 25503493
dgv1700e212 CNV loss 25503493
dgv1701e212 CNV loss 25503493
dgv1703e212 CNV loss 25503493
dgv1704e212 CNV gain 25503493
dgv1705e212 CNV gain 25503493
dgv1706e212 CNV gain 25503493
dgv3438e59 CNV duplication 20981092
dgv56e213 CNV loss 24956385
dgv5868n100 CNV gain 25217958
dgv5869n100 CNV gain 25217958
dgv5872n100 CNV gain 25217958
dgv5873n100 CNV gain 25217958
dgv5874n100 CNV gain 25217958
dgv5875n100 CNV gain 25217958
dgv5876n100 CNV gain 25217958
dgv5877n100 CNV loss 25217958
dgv5878n100 CNV loss 25217958
dgv5879n100 CNV loss 25217958
dgv5880n100 CNV gain+loss 25217958
dgv5881n100 CNV gain+loss 25217958
dgv5882n100 CNV gain+loss 25217958
dgv5883n100 CNV gain+loss 25217958
dgv5884n100 CNV gain 25217958
dgv5885n100 CNV loss 25217958
dgv5886n100 CNV loss 25217958
dgv5887n100 CNV gain 25217958
dgv5888n100 CNV loss 25217958
dgv5889n100 CNV gain 25217958
dgv5890n100 CNV gain+loss 25217958
dgv5891n100 CNV gain+loss 25217958
dgv5892n100 CNV gain 25217958
dgv5893n100 CNV gain 25217958
dgv5894n100 CNV loss 25217958
dgv5895n100 CNV gain 25217958
dgv5896n100 CNV gain+loss 25217958
dgv5897n100 CNV loss 25217958
dgv5898n100 CNV gain 25217958
dgv5899n100 CNV loss 25217958
dgv5900n100 CNV loss 25217958
dgv5901n100 CNV gain 25217958
dgv5902n100 CNV gain 25217958
dgv5903n100 CNV loss 25217958
dgv5904n100 CNV loss 25217958
dgv5905n100 CNV loss 25217958
dgv5906n100 CNV gain+loss 25217958
dgv5907n100 CNV loss 25217958
dgv736n27 CNV loss 19166990
dgv990n67 CNV gain 20364138
dgv991n67 CNV gain 20364138
esv1057238 CNV insertion 17803354
esv2421434 CNV duplication 20811451
esv2421645 CNV duplication 20811451
esv2752087 CNV gain 17911159
esv2759401 CNV gain+loss 17122850
esv28111 CNV gain+loss 19812545
esv29987 CNV loss 17803354
esv3264495 CNV duplication 24192839
esv32812 CNV loss 17666407
esv3570714 CNV loss 25503493
esv3570715 CNV loss 25503493
esv3575987 CNV gain 25503493
esv3576070 CNV gain 25503493
esv3584838 CNV loss 24956385
esv3607835 CNV loss 21293372
esv3890779 CNV loss 25118596
esv3890780 CNV gain+loss 25118596
esv995174 CNV deletion 20482838
esv998752 CNV loss 20482838
nsv1016277 CNV gain 25217958
nsv1020113 CNV gain+loss 25217958
nsv1021970 CNV gain 25217958
nsv1026006 CNV gain 25217958
nsv1028693 CNV gain+loss 25217958
nsv1028946 CNV gain 25217958
nsv1030236 CNV loss 25217958
nsv1032674 CNV gain+loss 25217958
nsv1077997 CNV duplication 25765185
nsv10799 CNV gain+loss 18304495
nsv1119203 CNV duplication 24896259
nsv1124934 CNV duplication 24896259
nsv1148804 CNV duplication 26484159
nsv1151984 CNV insertion 26484159
nsv1152965 CNV deletion 26484159
nsv1161328 CNV duplication 26073780
nsv1161329 CNV duplication 26073780
nsv1161330 CNV deletion 26073780
nsv349805 CNV deletion 16902084
nsv428134 CNV gain 18775914
nsv437476 CNV loss 16327808
nsv442973 CNV gain 18776908
nsv462600 CNV loss 19166990
nsv514340 CNV gain 21397061
nsv5164 CNV insertion 18451855
nsv5166 CNV insertion 18451855
nsv524816 CNV loss 19592680
nsv525541 CNV gain 19592680
nsv600761 CNV loss 21841781
nsv600764 CNV gain 21841781
nsv820552 CNV duplication 20802225
nsv821644 CNV gain 15273396
nsv823390 CNV gain 20364138
nsv830568 CNV gain+loss 17160897
nsv950753 CNV duplication 24416366
nsv950754 CNV duplication 24416366
nsv969342 CNV duplication 23825009
nsv981096 CNV duplication 23825009
nsv981097 CNV duplication 23825009
nsv981349 CNV duplication 23825009

Variation tolerance for DUSP22 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP22 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP22 Gene

Disorders for DUSP22 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUSP22 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUSP22

genes like me logo Genes that share disorders with DUSP22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP22 Gene

Publications for DUSP22 Gene

  1. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. (PMID: 11717427) Shen Y … Tonks NK (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58
  2. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. (PMID: 20018849) Li JP … Tan TH (The Journal of biological chemistry 2010) 3 22 58
  3. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. (PMID: 17384676) Sekine Y … Matsuda T (Oncogene 2007) 3 22 58
  4. Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution. (PMID: 17068812) Yokota T … Sugio S (Proteins 2007) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for DUSP22 Gene

Sources for DUSP22 Gene

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