Aliases for WRNIP1 Gene
External Ids for WRNIP1 Gene
Previous GeneCards Identifiers for WRNIP1 Gene
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for WRNIP1 Gene
WRNIP1 (Werner Helicase Interacting Protein 1) is a Protein Coding gene. Diseases associated with WRNIP1 include Brain Compression and Posterior Myocardial Infarction. Gene Ontology (GO) annotations related to this gene include identical protein binding and four-way junction helicase activity.
UniProtKB/Swiss-Prot for WRNIP1 Gene
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 Lys-63-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.