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Aliases for WRNIP1 Gene

Aliases for WRNIP1 Gene

  • Werner Helicase Interacting Protein 1 2 3 5
  • WHIP 3 4
  • Werner Helicase-Interacting Protein 1 4
  • Putative Helicase RUVBL 3
  • ATPase WRNIP1 3
  • EC 3.6.1.3 4
  • BA420G6.2 3
  • EC 3.6.1 56

External Ids for WRNIP1 Gene

Previous GeneCards Identifiers for WRNIP1 Gene

  • GC06P002755
  • GC06P002710

Summaries for WRNIP1 Gene

Entrez Gene Summary for WRNIP1 Gene

  • Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for WRNIP1 Gene

WRNIP1 (Werner Helicase Interacting Protein 1) is a Protein Coding gene. Diseases associated with WRNIP1 include Brain Compression and Posterior Myocardial Infarction. Gene Ontology (GO) annotations related to this gene include identical protein binding and four-way junction helicase activity.

UniProtKB/Swiss-Prot for WRNIP1 Gene

  • Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 Lys-63-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.

Gene Wiki entry for WRNIP1 Gene

Additional gene information for WRNIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRNIP1 Gene

Genomics for WRNIP1 Gene

GeneHancer (GH) Regulatory Elements for WRNIP1 Gene

Promoters and enhancers for WRNIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I002763 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 869 5.8 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 PIR54135 WRNIP1 MYLK4 GC06P002769
GH06I002979 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 20.8 +220.8 220779 13.6 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 NQO2 LINC01011 RIPK1 PSMG4 ENSG00000228170 WRNIP1 ENSG00000272320 LOC105374888 SERPINB9 SERPINB6
GH06I002845 Enhancer 1.4 Ensembl ENCODE dbSUPER 23.9 +81.2 81233 1.7 HDGF PKNOX1 FOXA2 ARNT ARID4B DMAP1 ZNF2 YY1 GTF3C2 ZNF766 WRNIP1 SERPINB9 ENSG00000232999 LINC01011 NQO2 SERPINB6 MYLK4 SERPINB1 MIR4645
GH06I003745 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +984.6 984594 8.8 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS PXDC1 ENSG00000270504 PSMG4 ENSG00000219992 WRNIP1 ENSG00000272277 ENSG00000260604 LOC100507336 TUBB2BP1
GH06I002836 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.3 +74.9 74884 6.7 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 SERPINB1 SERPINB9 SERPINB9P1 LINC01011 NQO2 ENSG00000232999 SERPINB6 WRNIP1 MYLK4 GC06P002818
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WRNIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WRNIP1 gene promoter:

Genomic Locations for WRNIP1 Gene

Genomic Locations for WRNIP1 Gene
chr6:2,765,341-2,786,952
(GRCh38/hg38)
Size:
21,612 bases
Orientation:
Plus strand
chr6:2,765,648-2,787,186
(GRCh37/hg19)

Genomic View for WRNIP1 Gene

Genes around WRNIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WRNIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WRNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRNIP1 Gene

Proteins for WRNIP1 Gene

  • Protein details for WRNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S55-WRIP1_HUMAN
    Recommended name:
    ATPase WRNIP1
    Protein Accession:
    Q96S55
    Secondary Accessions:
    • B2RDB0
    • Q53EP6
    • Q59ET8
    • Q5W0E2
    • Q5W0E4
    • Q8WV26
    • Q9H681
    • Q9NRJ6

    Protein attributes for WRNIP1 Gene

    Size:
    665 amino acids
    Molecular mass:
    72133 Da
    Quaternary structure:
    • Forms homooligomers (PubMed:18842586), possibly octamers. Directly interacts with POLD1, POLD2 and POLD4 (PubMed:15670210). Interacts with the N-terminal domain of WRN (By similarity). Interacts (via UBZ-type zinc finger) with monoubiquitin and polyubiquitin (PubMed:17550899, PubMed:18842586). Interacts with TRIM14 and PPP6C; these interactions positively regulate the RIG-I/DDX58 signaling pathway (PubMed:29053956).
    SequenceCaution:
    • Sequence=AAF80563.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15383.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WRNIP1 Gene

    Alternative splice isoforms for WRNIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WRNIP1 Gene

Selected DME Specific Peptides for WRNIP1 Gene

Q96S55:
  • LFIDEIH
  • FIDEIHR

Post-translational modifications for WRNIP1 Gene

  • Sumoylated with SUMO1 and SUMO2/3.
  • Ubiquitination at posLast=8181, posLast=141141, posLast=225225, posLast=286286, isoforms=2, 3301, isoforms=2, 3310, posLast=316316, isoforms=2, 3322, posLast=335335, posLast=482482, isoforms=2, 3, 4508, posLast=601601, isoforms=2, 3, 4627, isoforms=2, 3, 4636, and posLast=661661

Other Protein References for WRNIP1 Gene

Domains & Families for WRNIP1 Gene

Gene Families for WRNIP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WRNIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S55

UniProtKB/Swiss-Prot:

WRIP1_HUMAN :
  • The UBZ-type zinc finger binds ubiquitin.
  • Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
Domain:
  • The UBZ-type zinc finger binds ubiquitin.
Family:
  • Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
genes like me logo Genes that share domains with WRNIP1: view

Function for WRNIP1 Gene

Molecular function for WRNIP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 Lys-63-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.

Enzyme Numbers (IUBMB) for WRNIP1 Gene

Phenotypes From GWAS Catalog for WRNIP1 Gene

Gene Ontology (GO) - Molecular Function for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15670210
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IMP 15670210
genes like me logo Genes that share ontologies with WRNIP1: view
genes like me logo Genes that share phenotypes with WRNIP1: view

Animal Models for WRNIP1 Gene

MGI Knock Outs for WRNIP1:

Animal Model Products

miRNA for WRNIP1 Gene

miRTarBase miRNAs that target WRNIP1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WRNIP1 Gene

Localization for WRNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRNIP1 Gene

Nucleus. Cytoplasm. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000269 PubMed:18842586, ECO:0000269 PubMed:29053956}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WRNIP1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus ISS --
GO:0016020 membrane HDA,IDA 19946888
GO:0048471 perinuclear region of cytoplasm IDA 17888034
genes like me logo Genes that share ontologies with WRNIP1: view

Pathways & Interactions for WRNIP1 Gene

SuperPathways for WRNIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000731 DNA synthesis involved in DNA repair IDA 15670210
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0030174 regulation of DNA-dependent DNA replication initiation IDA 15670210
genes like me logo Genes that share ontologies with WRNIP1: view

No data available for Pathways by source and SIGNOR curated interactions for WRNIP1 Gene

Drugs & Compounds for WRNIP1 Gene

No Compound Related Data Available

Transcripts for WRNIP1 Gene

Unigene Clusters for WRNIP1 Gene

Werner helicase interacting protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WRNIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -

Relevant External Links for WRNIP1 Gene

GeneLoc Exon Structure for
WRNIP1
ECgene alternative splicing isoforms for
WRNIP1

Expression for WRNIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WRNIP1 Gene

Protein differential expression in normal tissues from HIPED for WRNIP1 Gene

This gene is overexpressed in Lymph node (11.1), Peripheral blood mononuclear cells (8.0), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WRNIP1 Gene



Protein tissue co-expression partners for WRNIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WRNIP1 Gene:

WRNIP1

SOURCE GeneReport for Unigene cluster for WRNIP1 Gene:

Hs.236828

mRNA Expression by UniProt/SwissProt for WRNIP1 Gene:

Q96S55-WRIP1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for WRNIP1 Gene

  • Liver(4.2)
  • Nervous system(3.7)
  • Lung(2.9)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with WRNIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WRNIP1 Gene

Orthologs for WRNIP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WRNIP1 33 34
  • 99 (n)
dog
(Canis familiaris)
Mammalia WRNIP1 33 34
  • 91.61 (n)
mouse
(Mus musculus)
Mammalia Wrnip1 33 16 34
  • 89.19 (n)
rat
(Rattus norvegicus)
Mammalia Wrnip1 33
  • 87.83 (n)
cow
(Bos Taurus)
Mammalia WRNIP1 33 34
  • 82.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WRNIP1 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WRNIP1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves WRNIP1 33 34
  • 74.03 (n)
lizard
(Anolis carolinensis)
Reptilia WRNIP1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wrnip1 33
  • 66.74 (n)
Str.10820 33
zebrafish
(Danio rerio)
Actinopterygii wrnip1 33 34
  • 68.13 (n)
Dr.16690 33
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL183W 33
  • 53.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGS1 33 34 36
  • 51.12 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19360g 33
  • 50.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G24290 33
  • 55.42 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08706 33
  • 52.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC26H5.02c 33
  • 52.92 (n)
Species where no ortholog for WRNIP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRNIP1 Gene

ENSEMBL:
Gene Tree for WRNIP1 (if available)
TreeFam:
Gene Tree for WRNIP1 (if available)

Paralogs for WRNIP1 Gene

No data available for Paralogs for WRNIP1 Gene

Variants for WRNIP1 Gene

Sequence variations from dbSNP and Humsavar for WRNIP1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000054432 -- 2,778,922(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000108001 -- 2,779,187(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000180073 -- 2,772,684(+) T/G intron_variant
rs1000585993 -- 2,765,439(+) G/A 5_prime_UTR_variant
rs1000789991 -- 2,779,721(+) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WRNIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1126742 CNV deletion 24896259
esv3607912 CNV gain 21293372
esv3607900 CNV gain 21293372
esv3396658 CNV insertion 20981092
esv3347625 CNV insertion 20981092
esv3309004 CNV mobile element insertion 20981092
esv3307182 CNV mobile element insertion 20981092
esv1193325 CNV insertion 17803354

Variation tolerance for WRNIP1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WRNIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WRNIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRNIP1 Gene

Disorders for WRNIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WRNIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
brain compression
  • compression of brain
posterior myocardial infarction
  • posterior myocardial infarction nos
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for WRNIP1

genes like me logo Genes that share disorders with WRNIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WRNIP1 Gene

Publications for WRNIP1 Gene

  1. A novel protein interacts with the Werner's syndrome gene product physically and functionally. (PMID: 11301316) Kawabe Yi … Enomoto T (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. (PMID: 18842586) Crosetto N … Dikic I (The Journal of biological chemistry 2008) 3 4 22 58
  3. Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PMID: 15670210) Tsurimoto T … Enomoto T (Genes to cells : devoted to molecular & cellular mechanisms 2005) 3 4 22 58
  4. Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. (PMID: 29053956) Tan P … Wang RF (Molecular cell 2017) 3 4 58
  5. A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. (PMID: 27062441) Suzuki N … Kawasaki M (The FEBS journal 2016) 3 4 58

Products for WRNIP1 Gene

Sources for WRNIP1 Gene

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