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Aliases for SLAMF8 Gene

Aliases for SLAMF8 Gene

  • SLAM Family Member 8 2 3 3 5
  • BCM-Like Membrane Protein 3 4
  • BLAME 3 4
  • B Lymphocyte Activator Macrophage Expressed 3
  • B-Lymphocyte Activator Macrophage Expressed 4
  • CD353 Antigen 4
  • SBBI42 3
  • CD353 3

External Ids for SLAMF8 Gene

Previous GeneCards Identifiers for SLAMF8 Gene

  • GC01P157013
  • GC01P156609
  • GC01P158063
  • GC01P131152

Summaries for SLAMF8 Gene

Entrez Gene Summary for SLAMF8 Gene

  • This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLAMF8 Gene

SLAMF8 (SLAM Family Member 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLAMF8 Gene

  • May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Gene Wiki entry for SLAMF8 Gene

Additional gene information for SLAMF8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF8 Gene

Genomics for SLAMF8 Gene

GeneHancer (GH) Regulatory Elements for SLAMF8 Gene

Promoters and enhancers for SLAMF8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159825 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.7 +0.1 73 1.8 ZNF687 PKNOX1 MAX MNT MEF2B RELA POLR2A IKZF1 MYC RUNX3 SLAMF8 GC01M159841
GH01J159827 Enhancer 0.3 ENCODE 650.7 +1.1 1136 0.2 RUNX3 SLAMF8 GC01M159841
GH01J159824 Enhancer 0.2 FANTOM5 658.4 -1.9 -1911 0.4 SLAMF8 SNHG28 SLAMF9 OR10J5 LOC105371464
GH01J159908 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.6 +90.8 90833 18.5 CLOCK FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A TAGLN2 GC01M159886 GC01M159919 CFAP45 ENSG00000228606 NCSTN SLAMF8 RAD1P2 ENSG00000272668 SNHG28
GH01J159888 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17 +63.8 63833 3 HDGF ATF1 SIN3A ZNF2 IRF4 GLIS2 ARID2 ZNF207 ZNF143 ATF7 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLAMF8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLAMF8 gene promoter:
  • Meis-1
  • HOXA9B
  • HOXA9
  • Meis-1b
  • Spz1
  • oct-B2
  • Oct-B1
  • oct-B3
  • POU2F1
  • POU2F1a

Genomic Locations for SLAMF8 Gene

Genomic Locations for SLAMF8 Gene
10,848 bases
Plus strand
10,804 bases
Plus strand

Genomic View for SLAMF8 Gene

Genes around SLAMF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF8 Gene

Proteins for SLAMF8 Gene

  • Protein details for SLAMF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLAM family member 8
    Protein Accession:
    Secondary Accessions:
    • Q32MC6
    • Q5VU15

    Protein attributes for SLAMF8 Gene

    285 amino acids
    Molecular mass:
    31670 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLAMF8 Gene


neXtProt entry for SLAMF8 Gene

Post-translational modifications for SLAMF8 Gene

No data available for DME Specific Peptides for SLAMF8 Gene

Domains & Families for SLAMF8 Gene

Gene Families for SLAMF8 Gene

Protein Domains for SLAMF8 Gene

Suggested Antigen Peptide Sequences for SLAMF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SLAMF8: view

No data available for UniProtKB/Swiss-Prot for SLAMF8 Gene

Function for SLAMF8 Gene

Molecular function for SLAMF8 Gene

UniProtKB/Swiss-Prot Function:
May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Phenotypes From GWAS Catalog for SLAMF8 Gene

genes like me logo Genes that share phenotypes with SLAMF8: view

Animal Models for SLAMF8 Gene

MGI Knock Outs for SLAMF8:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLAMF8

miRNA for SLAMF8 Gene

miRTarBase miRNAs that target SLAMF8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLAMF8 Gene

Localization for SLAMF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAMF8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLAMF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLAMF8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLAMF8 Gene

Pathways & Interactions for SLAMF8 Gene

SuperPathways for SLAMF8 Gene

No Data Available

Interacting Proteins for SLAMF8 Gene

Gene Ontology (GO) - Biological Process for SLAMF8 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLAMF8 Gene

Drugs & Compounds for SLAMF8 Gene

No Compound Related Data Available

Transcripts for SLAMF8 Gene

mRNA/cDNA for SLAMF8 Gene

Unigene Clusters for SLAMF8 Gene

SLAM family member 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP2: - -
SP3: -

Relevant External Links for SLAMF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLAMF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLAMF8 Gene

mRNA differential expression in normal tissues according to GTEx for SLAMF8 Gene

This gene is overexpressed in Spleen (x5.4) and Lung (x4.9).

Protein differential expression in normal tissues from HIPED for SLAMF8 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLAMF8 Gene

Protein tissue co-expression partners for SLAMF8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLAMF8 Gene:


SOURCE GeneReport for Unigene cluster for SLAMF8 Gene:


mRNA Expression by UniProt/SwissProt for SLAMF8 Gene:

Tissue specificity: Expressed in lymph node, spleen, thymus and bone marrow.

Evidence on tissue expression from TISSUES for SLAMF8 Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with SLAMF8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLAMF8 Gene

Orthologs for SLAMF8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLAMF8 34 33
  • 99.33 (n)
(Bos Taurus)
Mammalia SLAMF8 34 33
  • 85.24 (n)
(Rattus norvegicus)
Mammalia Slamf8 33
  • 80.39 (n)
(Mus musculus)
Mammalia Slamf8 16 34 33
  • 80.1 (n)
(Canis familiaris)
Mammalia SLAMF8 34
  • 74 (a)
(Monodelphis domestica)
Mammalia SLAMF8 34
  • 64 (a)
Species where no ortholog for SLAMF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF8 Gene

Gene Tree for SLAMF8 (if available)
Gene Tree for SLAMF8 (if available)
Evolutionary constrained regions (ECRs) for SLAMF8: view image

Paralogs for SLAMF8 Gene

No data available for Paralogs for SLAMF8 Gene

Variants for SLAMF8 Gene

Sequence variations from dbSNP and Humsavar for SLAMF8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000063978 -- 159,835,694(+) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000118470 -- 159,827,992(+) C/T intron_variant
rs1000265864 -- 159,832,736(+) A/T intron_variant
rs1000436525 -- 159,835,455(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000629874 -- 159,831,249(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF8 Gene

Variant ID Type Subtype PubMed ID
esv3587702 CNV loss 21293372
esv3587703 CNV gain 21293372
nsv1005195 CNV gain 25217958

Variation tolerance for SLAMF8 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLAMF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF8 Gene

Disorders for SLAMF8 Gene

Additional Disease Information for SLAMF8

No disorders were found for SLAMF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAMF8 Gene

Publications for SLAMF8 Gene

  1. Cloning, expression, and function of BLAME, a novel member of the CD2 family. (PMID: 11313408) Kingsbury GA … Villeval JL (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLAMF8 Gene

Sources for SLAMF8 Gene

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