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Aliases for PSG4 Gene

Aliases for PSG4 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 4 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 4 2 3
  • Pregnancy-Specific Beta-1-Glycoprotein 9 3 4
  • Pregnancy-Specific Glycoprotein 4 3 4
  • Pregnancy-Specific Glycoprotein 9 3 4
  • PS-Beta-G-4 3 4
  • PS-Beta-G-9 3 4
  • PSBG-4 3 4
  • PSBG-9 3 4
  • PSG9 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein-4 3
  • CGM4 4

External Ids for PSG4 Gene

Previous GeneCards Identifiers for PSG4 Gene

  • GC19M044343
  • GC19M044088
  • GC19M048372
  • GC19M048388
  • GC19M048124
  • GC19M047918
  • GC19M043696
  • GC19M040126

Summaries for PSG4 Gene

Entrez Gene Summary for PSG4 Gene

  • The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PSG4 Gene

PSG4 (Pregnancy Specific Beta-1-Glycoprotein 4) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. An important paralog of this gene is PSG8.

Gene Wiki entry for PSG4 Gene

Additional gene information for PSG4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG4 Gene

Genomics for PSG4 Gene

GeneHancer (GH) Regulatory Elements for PSG4 Gene

Promoters and enhancers for PSG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043200 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 607.1 +4.1 4100 6.2 SIN3A FEZF1 GLI4 ZNF416 FOS KLF13 SP3 REST TSHZ1 ZNF518A PSG4 ZNF223 ZNF576 ZNF221 ZNF225 ZNF283 ZNF226 ZNF45 LOC101928063 ENSG00000267191
GH19I043180 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 52.8 +23.2 23212 6.4 NFIB ZSCAN4 INSM2 NEUROD1 NFXL1 FEZF1 GLI4 ZEB1 ZNF335 ZNF366 PSG5 PSG4 ZNF45 ZNF225 ZNF283 ZNF155 ZNF221 ZNF223 ZNF226 ZNF234
GH19I043263 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 24.1 -59.5 -59469 5.7 PKNOX1 NFIB ZSCAN4 INSM2 FEZF1 ZEB1 ZNF335 ZNF366 SCRT2 FOS PSG9 PSG4 LOC100505715 ZNF428 ZNF575 LOC100379224 MEGF8 ZNF404 ZNF576 PSG5
GH19I043020 Enhancer 1.2 FANTOM5 Ensembl ENCODE 16.5 +184.8 184790 3.7 ZBTB6 ZBTB21 JUN MAX SIN3A ZEB1 HIC1 ZNF335 GATA3 ZNF366 PSG4 ENSG00000231412 GC19M043001 PSG11 ENSG00000282943
GH19I043147 Enhancer 0.4 ENCODE 48.4 +58.7 58708 1.9 JUND ZNF316 REST PSG4 PSG5 ENSG00000227606 GC19P043117 GC19P043035 ENSG00000282943
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSG4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSG4 gene promoter:

Genomic Locations for PSG4 Gene

Genomic Locations for PSG4 Gene
chr19:43,192,702-43,207,299
(GRCh38/hg38)
Size:
14,598 bases
Orientation:
Minus strand
chr19:43,696,854-43,711,451
(GRCh37/hg19)

Genomic View for PSG4 Gene

Genes around PSG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG4 Gene

Proteins for PSG4 Gene

  • Protein details for PSG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00888-PSG4_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 4
    Protein Accession:
    Q00888
    Secondary Accessions:
    • E7EX79
    • Q13047
    • Q13048
    • Q15234
    • Q15240
    • Q9UQ76

    Protein attributes for PSG4 Gene

    Size:
    419 amino acids
    Molecular mass:
    47113 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60208.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=M32625; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PSG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSG4 Gene

Post-translational modifications for PSG4 Gene

  • Glycosylation at isoforms=2, 3104, isoforms=2, 3111, isoforms=2199, isoforms=3268, Asn299, and Asn303

No data available for DME Specific Peptides for PSG4 Gene

Domains & Families for PSG4 Gene

Gene Families for PSG4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q00888

UniProtKB/Swiss-Prot:

PSG4_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG4: view

Function for PSG4 Gene

Molecular function for PSG4 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 4,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
genes like me logo Genes that share phenotypes with PSG4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG4 Gene

Localization for PSG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PSG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with PSG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG4 Gene

Pathways & Interactions for PSG4 Gene

genes like me logo Genes that share pathways with PSG4: view

Pathways by source for PSG4 Gene

Interacting Proteins for PSG4 Gene

Gene Ontology (GO) - Biological Process for PSG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 7794280
genes like me logo Genes that share ontologies with PSG4: view

No data available for SIGNOR curated interactions for PSG4 Gene

Drugs & Compounds for PSG4 Gene

(1) Drugs for PSG4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PSG4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSG4: view

Transcripts for PSG4 Gene

mRNA/cDNA for PSG4 Gene

(12) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSG4 Gene

Pregnancy specific beta-1-glycoprotein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSG4 Gene

No ASD Table

Relevant External Links for PSG4 Gene

GeneLoc Exon Structure for
PSG4
ECgene alternative splicing isoforms for
PSG4

Expression for PSG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG4 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.7) and Skin - Not Sun Exposed (Suprapubic) (x6.5).

Protein differential expression in normal tissues from HIPED for PSG4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSG4 Gene



Protein tissue co-expression partners for PSG4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSG4 Gene:

PSG4

SOURCE GeneReport for Unigene cluster for PSG4 Gene:

Hs.711363

Evidence on tissue expression from TISSUES for PSG4 Gene

  • Bone marrow(4)
genes like me logo Genes that share expression patterns with PSG4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG4 Gene

Orthologs for PSG4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG4 33 34
  • 96.47 (n)
cow
(Bos Taurus)
Mammalia CEACAM1 34
  • 34 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam9 34
  • 32 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 27 (a)
ManyToMany
Species where no ortholog for PSG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG4 Gene

ENSEMBL:
Gene Tree for PSG4 (if available)
TreeFam:
Gene Tree for PSG4 (if available)

Paralogs for PSG4 Gene

Variants for PSG4 Gene

Sequence variations from dbSNP and Humsavar for PSG4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000241267 -- 43,198,906(-) C/T intron_variant
rs1000296051 -- 43,194,770(-) A/C intron_variant
rs1000327846 -- 43,194,895(-) G/T intron_variant
rs1000628923 -- 43,194,087(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000661475 -- 43,194,272(-) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSG4 Gene

Variant ID Type Subtype PubMed ID
nsv1057657 CNV gain 25217958
nsv1055887 CNV gain+loss 25217958
esv7692 CNV loss 19470904
esv6630 CNV loss 19470904
esv3893219 CNV loss 25118596
esv3893217 CNV gain 25118596
esv3893216 CNV gain+loss 25118596
esv3644456 CNV loss 21293372
esv3644455 CNV loss 21293372
esv3644454 CNV gain 21293372
esv3644453 CNV loss 21293372
esv3644450 CNV loss 21293372
esv3644447 CNV loss 21293372
esv3644411 CNV loss 21293372
esv3556435 CNV deletion 23714750
esv3556434 CNV deletion 23714750
esv34676 CNV loss 17911159
esv33039 CNV gain 17666407
esv2758763 CNV gain+loss 17122850
esv2751795 CNV loss 17911159
esv2751794 CNV gain 17911159
esv2718604 CNV deletion 23290073
esv2718603 CNV deletion 23290073
esv2671292 CNV deletion 23128226
esv2664621 CNV deletion 23128226
esv2663048 CNV deletion 23128226
esv2659897 CNV deletion 23128226
esv2658764 CNV deletion 23128226
esv2657641 CNV deletion 23128226
esv2421574 OTHER complex 20811451
esv22277 CNV gain+loss 19812545
esv1002165 CNV gain 20482838
dgv73e203 CNV gain+loss 21179565
dgv662e214 CNV loss 21293372
dgv6497n54 CNV loss 21841781
dgv6496n54 CNV loss 21841781
dgv6495n54 CNV gain+loss 21841781
dgv6494n54 CNV loss 21841781
dgv6493n54 CNV loss 21841781
dgv6488n54 CNV gain 21841781
dgv6485n54 CNV loss 21841781
dgv6474n54 CNV loss 21841781
dgv6471n54 CNV loss 21841781
dgv6467n54 CNV loss 21841781
dgv6466n54 CNV gain 21841781
dgv645e199 CNV deletion 23128226
dgv590n67 CNV loss 20364138
dgv524e201 CNV deletion 23290073
dgv523e201 CNV deletion 23290073
dgv411n27 CNV loss 19166990
dgv3599n100 CNV loss 25217958
dgv3598n100 CNV loss 25217958
dgv3597n100 CNV loss 25217958
dgv3596n100 CNV gain+loss 25217958
dgv3595n100 CNV gain 25217958
dgv3594n100 CNV gain 25217958
dgv3593n100 CNV gain 25217958
dgv3592n100 CNV loss 25217958
dgv3591n100 CNV loss 25217958
dgv3590n100 CNV gain+loss 25217958
dgv3589n100 CNV loss 25217958
dgv3588n100 CNV gain 25217958
dgv3587n100 CNV gain 25217958
dgv3585n100 CNV loss 25217958
dgv3584n100 CNV gain 25217958
dgv3583n100 CNV loss 25217958
dgv3577n100 CNV gain 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3571n100 CNV loss 25217958
dgv3566n100 CNV gain 25217958
dgv3557n100 CNV gain 25217958
dgv34e213 CNV loss 24956385
dgv1786n106 CNV tandem duplication 24896259
dgv146n111 CNV deletion 26073780
dgv143n111 CNV deletion 26073780
dgv141e55 CNV loss 17911159
dgv140e55 CNV gain 17911159
nsv470145 CNV loss 18288195
nsv458705 CNV loss 19166990
nsv442769 CNV loss 18776908
nsv437833 CNV loss 16327808
nsv437832 CNV loss 16327808
nsv437182 CNV loss 16327808
nsv435702 CNV deletion 17901297
nsv2499 CNV deletion 18451855
nsv1160642 CNV deletion 26073780
nsv1153047 CNV deletion 26484159
nsv1140446 CNV deletion 24896259
nsv1133452 CNV deletion 24896259
nsv1123257 CNV deletion 24896259
nsv1072885 CNV deletion 25765185
nsv1064717 CNV gain+loss 25217958
nsv1064459 CNV loss 25217958
nsv1064376 CNV gain 25217958
nsv1063922 CNV gain+loss 25217958
nsv1061699 CNV loss 25217958
nsv1059308 CNV gain+loss 25217958
nsv1057839 CNV gain 25217958
nsv9730 CNV gain+loss 18304495
nsv963056 CNV duplication 23825009
nsv833838 CNV gain 17160897
nsv828557 CNV loss 20364138
nsv820547 CNV deletion 20802225
nsv817848 CNV loss 17921354
nsv579821 CNV loss 21841781
nsv579820 CNV loss 21841781
nsv579809 CNV gain 21841781
nsv579779 CNV loss 21841781
nsv579759 CNV loss 21841781
nsv516973 CNV gain+loss 19592680
nsv510925 OTHER complex 20534489
nsv482044 CNV gain 20164927

Variation tolerance for PSG4 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG4 Gene

Disorders for PSG4 Gene

Additional Disease Information for PSG4

No disorders were found for PSG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG4 Gene

Publications for PSG4 Gene

  1. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S … Hammarström S (Biochemical and biophysical research communications 1995) 3 4 22 58
  2. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PMID: 2783133) Zimmermann W … Thompson JA (Biochemical and biophysical research communications 1989) 2 3 4 58
  3. A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. (PMID: 9645429) Kimoto Y (Molecular & general genetics : MGG 1998) 3 22 58
  4. Characterization of new members of the pregnancy-specific beta 1-glycoprotein family. (PMID: 1922019) Chan WY … Tease LA (Molecular and cellular biochemistry 1991) 3 4 58
  5. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PMID: 1690992) Thompson J … Zaninetta D (Biochemical and biophysical research communications 1990) 3 4 58

Products for PSG4 Gene

Sources for PSG4 Gene

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