Aliases for PSG2 Gene
External Ids for PSG2 Gene
Previous HGNC Symbols for PSG2 Gene
Previous GeneCards Identifiers for PSG2 Gene
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
GeneCards Summary for PSG2 Gene
PSG2 (Pregnancy Specific Beta-1-Glycoprotein 2) is a Protein Coding gene. Diseases associated with PSG2 include Colorectal Cancer and Microinvasive Gastric Cancer. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. An important paralog of this gene is PSG11.