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Aliases for POLE4 Gene

Aliases for POLE4 Gene

  • DNA Polymerase Epsilon 4, Accessory Subunit 2 3 5
  • Polymerase (DNA) Epsilon 4, Accessory Subunit 2 3
  • DNA Polymerase Epsilon Subunit P12 3 4
  • DNA Polymerase II Subunit 4 3 4
  • Polymerase (DNA-Directed), Epsilon 4, Accessory Subunit 3
  • Polymerase (DNA-Directed), Epsilon 4 (P12 Subunit) 2
  • DNA Polymerase Epsilon Subunit 4 3
  • EC 4
  • YHHQ1 3
  • P12 3

External Ids for POLE4 Gene

Previous GeneCards Identifiers for POLE4 Gene

  • GC02P075323
  • GC02P075143
  • GC02P075160
  • GC02P075097
  • GC02P075185
  • GC02P074922

Summaries for POLE4 Gene

Entrez Gene Summary for POLE4 Gene

  • POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

CIViC summary for POLE4 Gene

GeneCards Summary for POLE4 Gene

POLE4 (DNA Polymerase Epsilon 4, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is NFYC.

UniProtKB/Swiss-Prot for POLE4 Gene

  • May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

Additional gene information for POLE4 Gene

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLE4 Gene

Genomics for POLE4 Gene

GeneHancer (GH) Regulatory Elements for POLE4 Gene

Promoters and enhancers for POLE4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J074957 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 353 1.8 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 POLE4 LINC01291 PCGF1 CCDC142 WBP1 HTRA2 AUP1 TTC31 MOGS MOB1A
GH02J074887 Enhancer 1 FANTOM5 ENCODE dbSUPER 6 -70.6 -70592 1.7 CTCF SSRP1 FOSL2 FOS RAD21 POLE4 HK2 LINC01291 GC02P074881 PIR41645
GH02J074892 Enhancer 0.7 ENCODE dbSUPER 5 -64.6 -64642 2.6 JUND EGR1 POLR2A JUN FOS M1AP SEMA4F LINC01291 POLE4 GC02P074881 PIR41645 HK2
GH02J074881 Enhancer 0.5 dbSUPER 4.8 -74.6 -74647 3.9 POLR2A NR2F1 MAX CREB1 FOS HK2 POLE4 GC02P074881 PIR41645 LINC01291
GH02J074939 Enhancer 0.9 ENCODE 0.4 -18.3 -18316 1.5 FOXA2 MLX ARID4B ZNF48 TCF12 NFKBIZ SP5 MIER2 PPARG KAT8 LINC01293 LINC01291 POLE4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLE4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLE4 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • XBP-1
  • Pax-5
  • YY1
  • GATA-1
  • TGIF
  • CP2
  • Lmo2

Genomic Locations for POLE4 Gene

Genomic Locations for POLE4 Gene
11,637 bases
Plus strand
11,637 bases
Plus strand

Genomic View for POLE4 Gene

Genes around POLE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLE4 Gene

Proteins for POLE4 Gene

  • Protein details for POLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA polymerase epsilon subunit 4
    Protein Accession:
    Secondary Accessions:
    • Q53TR2

    Protein attributes for POLE4 Gene

    117 amino acids
    Molecular mass:
    12209 Da
    Quaternary structure:
    • Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for further binding with POLE and POLE2.

neXtProt entry for POLE4 Gene

Post-translational modifications for POLE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLE4 Gene

Domains & Families for POLE4 Gene

Gene Families for POLE4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for POLE4 Gene

Suggested Antigen Peptide Sequences for POLE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POLE4: view

No data available for UniProtKB/Swiss-Prot for POLE4 Gene

Function for POLE4 Gene

Molecular function for POLE4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Enzyme Numbers (IUBMB) for POLE4 Gene

Gene Ontology (GO) - Molecular Function for POLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA,TAS --
GO:0005515 protein binding IPI 10801849
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with POLE4: view
genes like me logo Genes that share phenotypes with POLE4: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLE4 Gene

Localization for POLE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLE4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLE4 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10801849
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0008622 epsilon DNA polymerase complex IDA 10801849
genes like me logo Genes that share ontologies with POLE4: view

Pathways & Interactions for POLE4 Gene

SuperPathways for POLE4 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 CDK-mediated phosphorylation and removal of Cdc6
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 DNA Double-Strand Break Repair
5 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
genes like me logo Genes that share pathways with POLE4: view

Gene Ontology (GO) - Biological Process for POLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006270 DNA replication initiation TAS --
GO:0032201 telomere maintenance via semi-conservative replication TAS --
GO:0043966 histone H3 acetylation IDA 18838386
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with POLE4: view

No data available for SIGNOR curated interactions for POLE4 Gene

Drugs & Compounds for POLE4 Gene

(5) Drugs for POLE4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 81
Phosphoric acid Approved Pharma 0
dATP Experimental Pharma Full agonist, Agonist 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0

(2) Additional Compounds for POLE4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • Deoxy-TTP
  • Deoxythymidine 5'-triphosphate
  • Deoxythymidine triphosphate
genes like me logo Genes that share compounds with POLE4: view

Transcripts for POLE4 Gene

mRNA/cDNA for POLE4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POLE4 Gene

Polymerase (DNA-directed), epsilon 4, accessory subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLE4 Gene

No ASD Table

Relevant External Links for POLE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POLE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLE4 Gene

This gene is overexpressed in Cerebrospinal fluid (33.1), Peripheral blood mononuclear cells (23.4), and Bone (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POLE4 Gene

NURSA nuclear receptor signaling pathways regulating expression of POLE4 Gene:


SOURCE GeneReport for Unigene cluster for POLE4 Gene:


Evidence on tissue expression from TISSUES for POLE4 Gene

  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with POLE4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLE4 Gene

Orthologs for POLE4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POLE4 34 33
  • 98.53 (n)
(Canis familiaris)
Mammalia POLE4 34 33
  • 89.47 (n)
(Bos Taurus)
Mammalia POLE4 34 33
  • 89.21 (n)
(Mus musculus)
Mammalia Pole4 16 34 33
  • 86.61 (n)
(Rattus norvegicus)
Mammalia Pole4 33
  • 86.32 (n)
(Monodelphis domestica)
Mammalia POLE4 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia POLE4 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pole4 33
  • 60.32 (n)
Str.17248 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7362 33
(Danio rerio)
Actinopterygii zgc:110337 33
  • 63.33 (n)
POLE4 34
  • 40 (a)
Dr.14836 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12504 33
fruit fly
(Drosophila melanogaster)
Insecta Mes4 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea Y53F4B.3 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP5 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for POLE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLE4 Gene

Gene Tree for POLE4 (if available)
Gene Tree for POLE4 (if available)
Evolutionary constrained regions (ECRs) for POLE4: view image

Paralogs for POLE4 Gene

Paralogs for POLE4 Gene

(2) SIMAP similar genes for POLE4 Gene using alignment to 1 proteins:

  • DPOE4_HUMAN Pseudogenes for POLE4 Gene

genes like me logo Genes that share paralogs with POLE4: view

Variants for POLE4 Gene

Sequence variations from dbSNP and Humsavar for POLE4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000051384 -- 74,965,735(+) A/G/T intron_variant
rs1000077043 -- 74,963,542(+) C/T intron_variant
rs1000103146 -- 74,965,389(+) G/A intron_variant
rs1000261381 -- 74,963,681(+) G/A intron_variant
rs1000272127 -- 74,969,548(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for POLE4 Gene

Variant ID Type Subtype PubMed ID
dgv3872n100 CNV gain 25217958
esv2751900 CNV gain 17911159
esv3575258 CNV gain 25503493
nsv1001495 CNV gain 25217958
nsv526995 CNV gain 19592680
nsv582217 CNV gain 21841781
nsv834262 CNV gain 17160897
nsv998145 CNV loss 25217958

Variation tolerance for POLE4 Gene

Gene Damage Index Score: 9.38; 88.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLE4 Gene

Disorders for POLE4 Gene

Additional Disease Information for POLE4

No disorders were found for POLE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLE4 Gene

Publications for POLE4 Gene

  1. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. (PMID: 10801849) Li Y … Linn S (The Journal of biological chemistry 2000) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for POLE4 Gene

Sources for POLE4 Gene

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