Aliases for POLE4 Gene
External Ids for POLE4 Gene
Previous GeneCards Identifiers for POLE4 Gene
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
GeneCards Summary for POLE4 Gene
POLE4 (DNA Polymerase Epsilon 4, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is NFYC.
UniProtKB/Swiss-Prot for POLE4 Gene
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.