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Aliases for EIF5A2 Gene

Aliases for EIF5A2 Gene

  • Eukaryotic Translation Initiation Factor 5A2 2 3 5
  • EIF-5A-2 3 4
  • EIF-5A2 3 4
  • Eukaryotic Translation Initiation Factor 5A-2 3
  • Eukaryotic Initiation Factor 5A Isoform 2 4
  • Eukaryotic Initiation Factor 5A 3
  • EIF5AII 3

External Ids for EIF5A2 Gene

Previous GeneCards Identifiers for EIF5A2 Gene

  • GC03M167752
  • GC03M171659
  • GC03M172010
  • GC03M171927
  • GC03M172088
  • GC03M170607
  • GC03M167976

Summaries for EIF5A2 Gene

GeneCards Summary for EIF5A2 Gene

EIF5A2 (Eukaryotic Translation Initiation Factor 5A2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include RNA binding and translation elongation factor activity. An important paralog of this gene is EIF5A.

UniProtKB/Swiss-Prot for EIF5A2 Gene

  • mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Gene Wiki entry for EIF5A2 Gene

Additional gene information for EIF5A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5A2 Gene

Genomics for EIF5A2 Gene

GeneHancer (GH) Regulatory Elements for EIF5A2 Gene

Promoters and enhancers for EIF5A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J170907 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 655.7 -0.1 -123 2.9 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B CBX5 ZNF548 EIF5A2 PHC3 SEC62-AS1 RPL22L1 PRKCI GC03M170953
GH03J170723 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +182.1 182060 5.7 HDGF ARNT YBX1 NCOA2 ZNF766 ARID2 ZFP91 FOS RUNX3 CAVIN1 LOC101928583 EIF5A2 CLDN11 RPL22L1 ENSG00000239739 ENSG00000285051 ENSG00000285218
GH03J170808 Enhancer 1.4 FANTOM5 Ensembl ENCODE 3.5 +97.2 97155 6.6 HDGF PKNOX1 ARNT SIN3A ZNF2 ZNF766 E2F8 ZNF143 FOS DEK CLDN11 ENSG00000242578 RPL22L1 LOC101928583 EIF5A2 RNY5P3 LOC105374211 ENSG00000285051 ENSG00000285218
GH03J170749 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +156.2 156151 6.9 HDAC1 PKNOX1 NFRKB FEZF1 RFX5 ZNF335 ZNF766 RCOR1 FOS ATF7 LOC101928583 CLDN11 EIF5A2 ENSG00000239739 LOC105374211 ENSG00000285051 ENSG00000285218
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF5A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF5A2 gene promoter:
  • C/EBPalpha
  • p53
  • MAZR
  • ISGF-3
  • Msx-1
  • POU3F2
  • Pax-5
  • NF-Y
  • CBF(2)
  • E2F

Genomic Locations for EIF5A2 Gene

Genomic Locations for EIF5A2 Gene
chr3:170,888,415-170,908,693
(GRCh38/hg38)
Size:
20,279 bases
Orientation:
Minus strand
chr3:170,606,204-170,626,482
(GRCh37/hg19)
Size:
20,279 bases
Orientation:
Minus strand

Genomic View for EIF5A2 Gene

Genes around EIF5A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF5A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF5A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5A2 Gene

Proteins for EIF5A2 Gene

  • Protein details for EIF5A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV4-IF5A2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5A-2
    Protein Accession:
    Q9GZV4
    Secondary Accessions:
    • B2R4V5

    Protein attributes for EIF5A2 Gene

    Size:
    153 amino acids
    Molecular mass:
    16793 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EIF5A2 Gene

Post-translational modifications for EIF5A2 Gene

  • eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF5A2 Gene

No data available for DME Specific Peptides for EIF5A2 Gene

Domains & Families for EIF5A2 Gene

Gene Families for EIF5A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for EIF5A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZV4

UniProtKB/Swiss-Prot:

IF5A2_HUMAN :
  • Belongs to the eIF-5A family.
Family:
  • Belongs to the eIF-5A family.
genes like me logo Genes that share domains with EIF5A2: view

Function for EIF5A2 Gene

Molecular function for EIF5A2 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 14622290
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with EIF5A2: view
genes like me logo Genes that share phenotypes with EIF5A2: view

Animal Models for EIF5A2 Gene

MGI Knock Outs for EIF5A2:
  • Eif5a2 Eif5a2<tm1d(EUCOMM)Hmgu>

Animal Model Products

miRNA for EIF5A2 Gene

miRTarBase miRNAs that target EIF5A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF5A2 Gene

Localization for EIF5A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF5A2 Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF5A2 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with EIF5A2: view

Pathways & Interactions for EIF5A2 Gene

genes like me logo Genes that share pathways with EIF5A2: view

Gene Ontology (GO) - Biological Process for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006414 translational elongation IEA --
GO:0006452 translational frameshifting IEA --
GO:0007283 spermatogenesis NAS 11161802
GO:0008284 positive regulation of cell proliferation IGI 14622290
genes like me logo Genes that share ontologies with EIF5A2: view

No data available for SIGNOR curated interactions for EIF5A2 Gene

Drugs & Compounds for EIF5A2 Gene

(1) Additional Compounds for EIF5A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hypusine
  • N(6)-(4-amino-2-Hydroxybutyl)-L-lysine
34994-11-1
genes like me logo Genes that share compounds with EIF5A2: view

Transcripts for EIF5A2 Gene

mRNA/cDNA for EIF5A2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF5A2 Gene

Eukaryotic translation initiation factor 5A2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for EIF5A2 Gene

GeneLoc Exon Structure for
EIF5A2
ECgene alternative splicing isoforms for
EIF5A2

Expression for EIF5A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF5A2 Gene

Protein differential expression in normal tissues from HIPED for EIF5A2 Gene

This gene is overexpressed in Saliva (25.4), Heart (15.3), Plasma (8.8), and Urine (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF5A2 Gene



Protein tissue co-expression partners for EIF5A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF5A2 Gene:

EIF5A2

SOURCE GeneReport for Unigene cluster for EIF5A2 Gene:

Hs.164144

mRNA Expression by UniProt/SwissProt for EIF5A2 Gene:

Q9GZV4-IF5A2_HUMAN
Tissue specificity: Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.

Evidence on tissue expression from TISSUES for EIF5A2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with EIF5A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF5A2 Gene

Orthologs for EIF5A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF5A2 34 33
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF5A2 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF5A2 34 33
  • 95.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF5A2 34 33
  • 94.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif5a2 16 34 33
  • 94.12 (n)
rat
(Rattus norvegicus)
Mammalia Eif5a2 33
  • 93.25 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF5A2 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF5A2 34 33
  • 81.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF5A2 34
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia iff-2-prov 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.290 33
zebrafish
(Danio rerio)
Actinopterygii eif5a 34
  • 75 (a)
OneToMany
eif5a2 34
  • 74 (a)
OneToMany
pax6a 33
fruit fly
(Drosophila melanogaster)
Insecta eIF-5A 34 35
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea iff-2 34 35
  • 58 (a)
ManyToMany
iff-1 34 35
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ANB1 36 34
  • 62 (a)
HYP2 34
  • 62 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.15407 33
corn
(Zea mays)
Liliopsida Zm.761 33
rice
(Oryza sativa)
Liliopsida Os.6385 33
barley
(Hordeum vulgare)
Liliopsida Hv.7334 33
Species where no ortholog for EIF5A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF5A2 Gene

ENSEMBL:
Gene Tree for EIF5A2 (if available)
TreeFam:
Gene Tree for EIF5A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF5A2: view image

Paralogs for EIF5A2 Gene

Paralogs for EIF5A2 Gene

(2) SIMAP similar genes for EIF5A2 Gene using alignment to 5 proteins:

  • IF5A2_HUMAN
  • C9J4W5_HUMAN
  • C9J7B5_HUMAN
  • F8WCJ1_HUMAN
  • L8E8K4_HUMAN

Pseudogenes.org Pseudogenes for EIF5A2 Gene

genes like me logo Genes that share paralogs with EIF5A2: view

Variants for EIF5A2 Gene

Sequence variations from dbSNP and Humsavar for EIF5A2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000100359 -- 170,900,199(-) C/G/T intron_variant
rs1000231879 -- 170,907,413(-) T/C intron_variant
rs1000696157 -- 170,890,481(-) C/T 3_prime_UTR_variant
rs1000777466 -- 170,910,474(-) A/G upstream_transcript_variant
rs1001207487 -- 170,897,608(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF5A2 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER inversion 18451855

Variation tolerance for EIF5A2 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF5A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF5A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5A2 Gene

Disorders for EIF5A2 Gene

Additional Disease Information for EIF5A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EIF5A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF5A2 Gene

Publications for EIF5A2 Gene

  1. Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. (PMID: 16519677) Clement PM … Park MH (The FEBS journal 2006) 3 4 22 58
  2. Screening the SPO11 and EIF5A2 genes in a population of infertile men. (PMID: 16169419) Christensen GL … Carrell DT (Fertility and sterility 2005) 3 4 44 58
  3. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. (PMID: 11325856) Guan XY … Yang JM (Cancer research 2001) 3 4 22 58
  4. Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. (PMID: 11161802) Jenkins ZA … Johansson HE (Genomics 2001) 3 4 22 58
  5. Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. (PMID: 20112425) Tang DJ … Guan XY (Hepatology (Baltimore, Md.) 2010) 3 22 58

Products for EIF5A2 Gene

Sources for EIF5A2 Gene

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