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Aliases for KLK10 Gene

Aliases for KLK10 Gene

  • Kallikrein Related Peptidase 10 2 3 5
  • Normal Epithelial Cell-Specific 1 3 4
  • Protease Serine-Like 1 3 4
  • PRSSL1 3 4
  • NES1 3 4
  • Breast Normal Epithelial Cell Associated Serine Protease 3
  • Kallikrein 10 Protein 12 3
  • Kallikrein 10 Protein 13 3
  • Kallikrein 10 Protein 1 3
  • Kallikrein 10 Protein 2 3
  • Kallikrein 10 Protein 3 3
  • Kallikrein 10 Protein 4 3
  • Kallikrein 10 Protein 5 3
  • Kallikrein 10 Protein 7 3
  • Kallikrein 10 Protein 8 3
  • Kallikrein 10 Protein 9 3
  • Kallikrein 10 2
  • Kallikrein-10 3
  • EC 3.4.21.74 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56

External Ids for KLK10 Gene

Previous HGNC Symbols for KLK10 Gene

  • PRSSL1

Previous GeneCards Identifiers for KLK10 Gene

  • GC19M052148
  • GC19M051877
  • GC19M056193
  • GC19M056209
  • GC19M051516
  • GC19M047848

Summaries for KLK10 Gene

Entrez Gene Summary for KLK10 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK10 Gene

KLK10 (Kallikrein Related Peptidase 10) is a Protein Coding gene. Diseases associated with KLK10 include Ovarian Cancer and Breast Cancer. Among its related pathways are MSP-RON Signaling and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK10 Gene

  • Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Gene Wiki entry for KLK10 Gene

Additional gene information for KLK10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK10 Gene

Genomics for KLK10 Gene

GeneHancer (GH) Regulatory Elements for KLK10 Gene

Promoters and enhancers for KLK10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051018 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 574.4 +0.7 743 2.4 ZNF335 TCF12 GLIS2 ZNF302 EGR1 ZNF366 ZNF416 ETV6 EGR2 SMARCA5 KLK10 ZNF577 ZNF649 ZNF175 ENSG00000269483 KLK13 KLK6 ZNF350 ZNF615 KLK14
GH19I051021 Enhancer 0.7 ENCODE 550.8 -1.0 -1045 0.2 CTCF USF1 ZNF384 E4F1 RAD21 ZNF143 SMC3 RUNX3 MIXL1 ZNF654 KLK10 KLK11
GH19I051016 Enhancer 1.1 Ensembl ENCODE 23.6 +2.8 2798 1.5 PKNOX1 ATF1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 KLF13 SP3 ZNF175 ZNF615 KLK10 ZNF577 LRRC4B POLD1 SPACA6 ZNF613 ZNF350 KLK13
GH19I051136 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -120.5 -120526 9.4 PKNOX1 NFRKB ZBTB40 YY1 ZNF766 SMAD5 ZBTB11 CEBPB GTF2B USF2 SIGLEC7 SIGLEC17P CTU1 POLD1 SIGLEC9 ZNF616 KLK14 KLK10 SIGLEC10 CD33
GH19I050999 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 6.7 +18.6 18638 3.6 HDAC1 HDGF PKNOX1 ATF1 ZBTB40 POLR2B EGR1 ATF7 CREM USF2 KLK8 KLK10 ENSG00000269741 KLK9 KLK7 ENSG00000267879
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLK10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLK10 gene promoter:

Genomic Locations for KLK10 Gene

Genomic Locations for KLK10 Gene
chr19:51,012,739-51,020,175
(GRCh38/hg38)
Size:
7,437 bases
Orientation:
Minus strand
chr19:51,515,995-51,523,431
(GRCh37/hg19)

Genomic View for KLK10 Gene

Genes around KLK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK10 Gene

Proteins for KLK10 Gene

  • Protein details for KLK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43240-KLK10_HUMAN
    Recommended name:
    Kallikrein-10
    Protein Accession:
    O43240
    Secondary Accessions:
    • A6NC12
    • Q53YL3
    • Q99920
    • Q9GZW9

    Protein attributes for KLK10 Gene

    Size:
    276 amino acids
    Molecular mass:
    30170 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLK10 Gene

neXtProt entry for KLK10 Gene

Selected DME Specific Peptides for KLK10 Gene

O43240:
  • VLTAAHC
  • WVLTAAH
  • QGILSWG
  • SGGPLVC

Post-translational modifications for KLK10 Gene

Antibody Products

  • R&D Systems Antibodies for KLK10 (Kallikrein 10)

Domains & Families for KLK10 Gene

Gene Families for KLK10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for KLK10 Gene

Graphical View of Domain Structure for InterPro Entry

O43240

UniProtKB/Swiss-Prot:

KLK10_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK10: view

Function for KLK10 Gene

Molecular function for KLK10 Gene

UniProtKB/Swiss-Prot Function:
Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Enzyme Numbers (IUBMB) for KLK10 Gene

Phenotypes From GWAS Catalog for KLK10 Gene

Gene Ontology (GO) - Molecular Function for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 8764136
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK10: view
genes like me logo Genes that share phenotypes with KLK10: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK10 Gene

Localization for KLK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK10 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with KLK10: view

Pathways & Interactions for KLK10 Gene

genes like me logo Genes that share pathways with KLK10: view

Pathways by source for KLK10 Gene

Gene Ontology (GO) - Biological Process for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with KLK10: view

No data available for SIGNOR curated interactions for KLK10 Gene

Drugs & Compounds for KLK10 Gene

(9) Drugs for KLK10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK10: view

Transcripts for KLK10 Gene

Unigene Clusters for KLK10 Gene

Kallikrein-related peptidase 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3:

Relevant External Links for KLK10 Gene

GeneLoc Exon Structure for
KLK10
ECgene alternative splicing isoforms for
KLK10

Expression for KLK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK10 Gene

mRNA differential expression in normal tissues according to GTEx for KLK10 Gene

This gene is overexpressed in Esophagus - Mucosa (x23.1), Vagina (x6.8), Cervix - Ectocervix (x6.5), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for KLK10 Gene

This gene is overexpressed in Cervix (48.1), Saliva (8.2), and Hair follicle (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK10 Gene



Protein tissue co-expression partners for KLK10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLK10 Gene:

KLK10

SOURCE GeneReport for Unigene cluster for KLK10 Gene:

Hs.275464

mRNA Expression by UniProt/SwissProt for KLK10 Gene:

O43240-KLK10_HUMAN
Tissue specificity: Expressed in breast, ovary and prostate.

Evidence on tissue expression from TISSUES for KLK10 Gene

  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with KLK10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK10 Gene

Orthologs for KLK10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK10 33 34
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia KLK10 33 34
  • 86.71 (n)
cow
(Bos Taurus)
Mammalia KLK10 33 34
  • 82.49 (n)
mouse
(Mus musculus)
Mammalia Klk10 33 16 34
  • 76.89 (n)
rat
(Rattus norvegicus)
Mammalia Klk10 33
  • 75.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLK10 34
  • 48 (a)
OneToOne
Species where no ortholog for KLK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK10 Gene

ENSEMBL:
Gene Tree for KLK10 (if available)
TreeFam:
Gene Tree for KLK10 (if available)

Paralogs for KLK10 Gene

Paralogs for KLK10 Gene

genes like me logo Genes that share paralogs with KLK10: view

Variants for KLK10 Gene

Sequence variations from dbSNP and Humsavar for KLK10 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000071205 -- 51,016,933(-) G/T intron_variant
rs1000503355 -- 51,016,184(-) C/T intron_variant
rs1000806507 -- 51,022,105(-) G/T upstream_transcript_variant
rs1001073113 -- 51,018,541(-) A/G intron_variant
rs1001411902 -- 51,012,616(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KLK10 Gene

Variant ID Type Subtype PubMed ID
nsv579961 CNV loss 21841781
nsv1140251 OTHER inversion 24896259
esv2677627 CNV deletion 23128226

Variation tolerance for KLK10 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK10 Gene

Disorders for KLK10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLK10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
breast cancer
  • breast cancer, familial
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search KLK10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLK10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK10 Gene

Publications for KLK10 Gene

  1. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. (PMID: 8764136) Liu XL … Band V (Cancer research 1996) 2 3 4 22 58
  2. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. (PMID: 16103744) Yousef GM … Diamandis EP (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005) 3 4 22 58
  3. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. (PMID: 11920956) Bharaj BB … Diamandis EP (The Prostate 2002) 3 22 44 58
  4. The new human kallikrein gene family: implications in carcinogenesis. (PMID: 10675891) Diamandis EP … Obiezu CV (Trends in endocrinology and metabolism: TEM 2000) 2 3 22 58
  5. The role for NES1 serine protease as a novel tumor suppressor. (PMID: 9809976) Goyal J … Band V (Cancer research 1998) 3 4 22 58

Products for KLK10 Gene

Sources for KLK10 Gene

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