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Aliases for CHST7 Gene

Aliases for CHST7 Gene

  • Carbohydrate Sulfotransferase 7 2 3 5
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 5 3 4
  • Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 7 2 3
  • N-Acetylglucosamine 6-O-Sulfotransferase 4 3 4
  • GlcNAc6ST-4 3 4
  • Gn6st-4 3 4
  • C6ST-2 3 4
  • GST-5 3 4
  • Chondroitin 6-Sulfotransferase-2 3
  • Chondroitin 6-Sulfotransferase 2 4
  • EC 2.8.2.17 4
  • EC 2.8.2.- 4

External Ids for CHST7 Gene

Previous GeneCards Identifiers for CHST7 Gene

  • GC0XP045236
  • GC0XP044693
  • GC0XP045479
  • GC0XP046189
  • GC0XP046318
  • GC0XP046433
  • GC0XP044144

Summaries for CHST7 Gene

Entrez Gene Summary for CHST7 Gene

  • This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]

GeneCards Summary for CHST7 Gene

CHST7 (Carbohydrate Sulfotransferase 7) is a Protein Coding gene. Diseases associated with CHST7 include Colonic Benign Neoplasm. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and chondroitin 6-sulfotransferase activity. An important paralog of this gene is CHST2.

UniProtKB/Swiss-Prot for CHST7 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.

Gene Wiki entry for CHST7 Gene

Additional gene information for CHST7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST7 Gene

Genomics for CHST7 Gene

GeneHancer (GH) Regulatory Elements for CHST7 Gene

Promoters and enhancers for CHST7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI046572 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 577.4 +0.9 939 5.2 HDGF PKNOX1 ARID4B SIN3A GLIS2 ZNF143 ATF7 SP3 REST GLIS1 CHST7 SLC9A7 RP2 ZNF674 PIR58897
GH0XI046625 Enhancer 1.3 FANTOM5 Ensembl ENCODE 34.9 +54.4 54361 4.5 PKNOX1 FEZF1 BATF IRF4 SCRT2 ATF7 ETV6 FOS BCLAF1 IKZF2 CHST7 SLC9A7 RP2 ZNF674 PIR58897 PGAM1P7
GH0XI046577 Enhancer 0.7 FANTOM5 ENCODE 23.3 +3.8 3797 0.5 ZNF341 ZNF266 ZXDB CHST7 INE1 RP2 UBA1 LOC100113397 RBM10 ZNF674 PIR58897
GH0XI046791 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +219.1 219108 3.4 BATF BRCA1 YY1 FOS IKZF2 RUNX3 SMARCC1 JUNB CEBPB ZEB2 RP2 CHST7 SLC9A7 ZNF674
GH0XI046704 Enhancer 1.1 FANTOM5 ENCODE 11.9 +131.3 131288 1.9 HDGF RB1 BMI1 BATF IRF4 TCF12 ZNF143 ATF7 ETV6 BCLAF1 CHST7 YBX1P8 LOC100420317 SLC9A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHST7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHST7 gene promoter:

Genomic Locations for CHST7 Gene

Genomic Locations for CHST7 Gene
chrX:46,573,687-46,598,496
(GRCh38/hg38)
Size:
24,810 bases
Orientation:
Plus strand
chrX:46,433,192-46,457,843
(GRCh37/hg19)

Genomic View for CHST7 Gene

Genes around CHST7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST7 Gene

Proteins for CHST7 Gene

  • Protein details for CHST7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS84-CHST7_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 7
    Protein Accession:
    Q9NS84
    Secondary Accessions:
    • O75667

    Protein attributes for CHST7 Gene

    Size:
    486 amino acids
    Molecular mass:
    54266 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST7 Gene

Post-translational modifications for CHST7 Gene

  • Ubiquitination at posLast=272272
  • Glycosylation at Asn88, posLast=186186, and Asn407
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST7 Gene

Domains & Families for CHST7 Gene

Gene Families for CHST7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for CHST7 Gene

Suggested Antigen Peptide Sequences for CHST7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS84

UniProtKB/Swiss-Prot:

CHST7_HUMAN :
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
genes like me logo Genes that share domains with CHST7: view

Function for CHST7 Gene

Molecular function for CHST7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 6-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.

Enzyme Numbers (IUBMB) for CHST7 Gene

Gene Ontology (GO) - Molecular Function for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IDA 10913333
GO:0008146 sulfotransferase activity IEA --
GO:0008459 chondroitin 6-sulfotransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CHST7: view

Phenotypes for CHST7 Gene

genes like me logo Genes that share phenotypes with CHST7: view

miRNA for CHST7 Gene

miRTarBase miRNAs that target CHST7

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHST7 Gene

Localization for CHST7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 10781596
genes like me logo Genes that share ontologies with CHST7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHST7 Gene

Pathways & Interactions for CHST7 Gene

genes like me logo Genes that share pathways with CHST7: view

Gene Ontology (GO) - Biological Process for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005976 polysaccharide metabolic process TAS 10781596
GO:0006044 N-acetylglucosamine metabolic process IDA 10913333
GO:0006790 sulfur compound metabolic process IDA 10913333
GO:0030206 chondroitin sulfate biosynthetic process TAS,IDA --
genes like me logo Genes that share ontologies with CHST7: view

No data available for SIGNOR curated interactions for CHST7 Gene

Drugs & Compounds for CHST7 Gene

(2) Drugs for CHST7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chondroitin Nutra 48

(6) Additional Compounds for CHST7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Chondroitin 6'-sulfate
Keratan
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
69992-87-6
n-acetyllactosamine
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
32181-59-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with CHST7: view

Transcripts for CHST7 Gene

mRNA/cDNA for CHST7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHST7 Gene

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST7 Gene

No ASD Table

Relevant External Links for CHST7 Gene

GeneLoc Exon Structure for
CHST7
ECgene alternative splicing isoforms for
CHST7

Expression for CHST7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHST7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST7 Gene

This gene is overexpressed in Ovary (x5.3).

Protein differential expression in normal tissues from HIPED for CHST7 Gene

This gene is overexpressed in Ovary (40.3) and Testis (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHST7 Gene



Protein tissue co-expression partners for CHST7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHST7 Gene:

CHST7

SOURCE GeneReport for Unigene cluster for CHST7 Gene:

Hs.129955

mRNA Expression by UniProt/SwissProt for CHST7 Gene:

Q9NS84-CHST7_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin.

Evidence on tissue expression from TISSUES for CHST7 Gene

  • Nervous system(4.4)
  • Liver(4.1)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with CHST7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST7 Gene

Orthologs for CHST7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST7 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CHST7 33 34
  • 90.95 (n)
cow
(Bos Taurus)
Mammalia CHST7 33 34
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Chst7 33
  • 85.22 (n)
mouse
(Mus musculus)
Mammalia Chst7 33 16 34
  • 84.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CHST7 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chst7 33
  • 62.23 (n)
Str.16127 33
zebrafish
(Danio rerio)
Actinopterygii LOC563748 33
  • 60.34 (n)
CHST7 34
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9550 34
  • 21 (a)
ManyToMany
CG31637 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
CSA.5535 34
  • 19 (a)
ManyToMany
-- 34
  • 18 (a)
ManyToMany
Species where no ortholog for CHST7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST7 Gene

ENSEMBL:
Gene Tree for CHST7 (if available)
TreeFam:
Gene Tree for CHST7 (if available)

Paralogs for CHST7 Gene

Paralogs for CHST7 Gene

(4) SIMAP similar genes for CHST7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST7: view

Variants for CHST7 Gene

Sequence variations from dbSNP and Humsavar for CHST7 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000004642 -- 46,582,467(+) T/C intron_variant
rs1000323288 -- 46,574,795(+) C/G coding_sequence_variant, synonymous_variant
rs1000483927 -- 46,585,100(+) A/G intron_variant
rs1000738310 -- 46,590,395(+) A/G intron_variant
rs1001000422 -- 46,596,213(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHST7 Gene

Variant ID Type Subtype PubMed ID
esv25002 CNV loss 19812545
esv3576853 CNV gain 25503493

Variation tolerance for CHST7 Gene

Gene Damage Index Score: 0.98; 20.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHST7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST7 Gene

Disorders for CHST7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHST7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CHST7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHST7

genes like me logo Genes that share disorders with CHST7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHST7 Gene

Publications for CHST7 Gene

  1. Molecular cloning and expression of a novel chondroitin 6-O-sulfotransferase. (PMID: 10781596) Kitagawa H … Sugahara K (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5). (PMID: 10956661) Bhakta S … Hemmerich S (The Journal of biological chemistry 2000) 3 4 22 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CHST7 Gene

Sources for CHST7 Gene

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