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Aliases for EIF4ENIF1 Gene

Aliases for EIF4ENIF1 Gene

  • Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1 2 3 4 5
  • EIF4E Transporter 3 4
  • 4E-T 3 4
  • Eukaryotic Translation Initiation Factor 4E Transporter 3
  • 2610509L04Rik 3
  • Clast4 3

External Ids for EIF4ENIF1 Gene

Previous GeneCards Identifiers for EIF4ENIF1 Gene

  • GC22M028531
  • GC22M030159
  • GC22M031835
  • GC22M014796

Summaries for EIF4ENIF1 Gene

Entrez Gene Summary for EIF4ENIF1 Gene

  • The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for EIF4ENIF1 Gene

EIF4ENIF1 (Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1) is a Protein Coding gene. Diseases associated with EIF4ENIF1 include Retinitis Pigmentosa, Y-Linked and Esotropia. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

  • Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Gene Wiki entry for EIF4ENIF1 Gene

Additional gene information for EIF4ENIF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4ENIF1 Gene

Genomics for EIF4ENIF1 Gene

GeneHancer (GH) Regulatory Elements for EIF4ENIF1 Gene

Promoters and enhancers for EIF4ENIF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J031493 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 650.7 +0.4 409 4.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 ZNF207 SFI1 EIF4ENIF1 PIK3IP1 PISD DRG1
GH22J031488 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.4 +5.7 5748 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A ZNF2 IRF4 YY1 SFI1 EIF4ENIF1 TUG1 DEPDC5 PRR14L PES1 MORC2 DRG1
GH22J031747 Promoter/Enhancer 1.5 Ensembl ENCODE 22.5 -253.2 -253157 4 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 ZNF207 PRR14L TUG1 EIF4ENIF1 MORC2 SFI1 ENSG00000241954 DEPDC5 PIK3IP1 PISD
GH22J031658 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 -164.9 -164939 5.2 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 PISD TUG1 RTCB MORC2 PRR14L DEPDC5 RNF185 RPS17P16 EIF4ENIF1 ENSG00000240591
GH22J031397 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 +96.6 96629 3.3 HDGF FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B DRG1 SFI1 LINC01521 PATZ1 ENSG00000240591 EIF4ENIF1 PIK3IP1 PIR44980
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4ENIF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF4ENIF1 gene promoter:
  • Lmo2
  • Meis-1b
  • Meis-1a
  • Meis-1
  • HOXA9
  • HOXA9B
  • Bach1
  • Sp1

Genomic Locations for EIF4ENIF1 Gene

Genomic Locations for EIF4ENIF1 Gene
59,146 bases
Minus strand
59,132 bases
Minus strand

Genomic View for EIF4ENIF1 Gene

Genes around EIF4ENIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4ENIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4ENIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4ENIF1 Gene

Proteins for EIF4ENIF1 Gene

  • Protein details for EIF4ENIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Eukaryotic translation initiation factor 4E transporter
    Protein Accession:
    Secondary Accessions:
    • B1AKL2
    • B1AKL3
    • B2RBF1
    • Q8NCF2
    • Q9H708

    Protein attributes for EIF4ENIF1 Gene

    985 amino acids
    Molecular mass:
    108201 Da
    Quaternary structure:
    • Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.
    • Sequence=BAB15092.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF4ENIF1 Gene

    Alternative splice isoforms for EIF4ENIF1 Gene


neXtProt entry for EIF4ENIF1 Gene

Post-translational modifications for EIF4ENIF1 Gene

  • Ubiquitination at Lys492
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4ENIF1 Gene

Domains & Families for EIF4ENIF1 Gene

Gene Families for EIF4ENIF1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF4ENIF1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EIF4ENIF1: view

No data available for UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Function for EIF4ENIF1 Gene

Molecular function for EIF4ENIF1 Gene

UniProtKB/Swiss-Prot Function:
Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Phenotypes From GWAS Catalog for EIF4ENIF1 Gene

Gene Ontology (GO) - Molecular Function for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003729 mRNA binding IEA --
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 10856257
GO:0008565 protein transporter activity TAS 10856257
genes like me logo Genes that share ontologies with EIF4ENIF1: view
genes like me logo Genes that share phenotypes with EIF4ENIF1: view

Animal Model Products

miRNA for EIF4ENIF1 Gene

miRTarBase miRNAs that target EIF4ENIF1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4ENIF1 Gene

Localization for EIF4ENIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4ENIF1 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus TAS 10856257
GO:0005737 cytoplasm TAS 10856257
GO:0005829 cytosol IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with EIF4ENIF1: view

Pathways & Interactions for EIF4ENIF1 Gene

SuperPathways for EIF4ENIF1 Gene

SuperPathway Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with EIF4ENIF1: view

Pathways by source for EIF4ENIF1 Gene

1 Cell Signaling Technology pathway for EIF4ENIF1 Gene

SIGNOR curated interactions for EIF4ENIF1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA --
GO:0015031 protein transport IEA --
GO:0017148 negative regulation of translation IEA --
GO:0019827 stem cell population maintenance IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with EIF4ENIF1: view

Drugs & Compounds for EIF4ENIF1 Gene

No Compound Related Data Available

Transcripts for EIF4ENIF1 Gene

mRNA/cDNA for EIF4ENIF1 Gene

Unigene Clusters for EIF4ENIF1 Gene

Eukaryotic translation initiation factor 4E nuclear import factor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4ENIF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - -
SP2: - - - - - - - - - -
SP3: -
SP5: - - - -
SP6: - -
SP7: - - - - - -
SP10: -

ExUns: 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: - -
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for EIF4ENIF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EIF4ENIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4ENIF1 Gene

Protein differential expression in normal tissues from HIPED for EIF4ENIF1 Gene

This gene is overexpressed in Testis (19.5), Peripheral blood mononuclear cells (7.0), Placenta (6.5), and Fetal testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4ENIF1 Gene

Protein tissue co-expression partners for EIF4ENIF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4ENIF1 Gene:


SOURCE GeneReport for Unigene cluster for EIF4ENIF1 Gene:


mRNA Expression by UniProt/SwissProt for EIF4ENIF1 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for EIF4ENIF1 Gene

  • Nervous system(4.8)
  • Intestine(4.2)
  • Liver(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with EIF4ENIF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4ENIF1 Gene

Orthologs for EIF4ENIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EIF4ENIF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EIF4ENIF1 34 33
  • 99.76 (n)
(Canis familiaris)
Mammalia EIF4ENIF1 34 33
  • 92.66 (n)
(Bos Taurus)
Mammalia EIF4ENIF1 34 33
  • 91.87 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
-- 34
  • 83 (a)
(Rattus norvegicus)
Mammalia Eif4enif1 33
  • 88.96 (n)
(Mus musculus)
Mammalia Eif4enif1 16 34 33
  • 88.64 (n)
(Monodelphis domestica)
Mammalia EIF4ENIF1 34
  • 75 (a)
(Gallus gallus)
Aves EIF4ENIF1 34 33
  • 76.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4enif1 33
  • 65.28 (n)
Str.10069 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2368 33
(Danio rerio)
Actinopterygii eif4enif1 34 33
  • 59.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for EIF4ENIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4ENIF1 Gene

Gene Tree for EIF4ENIF1 (if available)
Gene Tree for EIF4ENIF1 (if available)
Evolutionary constrained regions (ECRs) for EIF4ENIF1: view image

Paralogs for EIF4ENIF1 Gene

No data available for Paralogs for EIF4ENIF1 Gene

Variants for EIF4ENIF1 Gene

Sequence variations from dbSNP and Humsavar for EIF4ENIF1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000046900 -- 31,449,137(-) C/T intron_variant
rs1000108240 -- 31,485,790(-) G/C intron_variant
rs1000129182 -- 31,449,945(-) G/A intron_variant
rs1000174500 -- 31,455,445(-) C/A intron_variant
rs1000361263 -- 31,477,806(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4ENIF1 Gene

Variant ID Type Subtype PubMed ID
dgv839e214 CNV loss 21293372
esv3647588 CNV gain 21293372
nsv1060776 CNV gain 25217958
nsv1063634 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv1139057 CNV deletion 24896259
nsv588894 CNV loss 21841781
nsv834176 CNV loss 17160897
nsv9897 CNV gain 18304495

Variation tolerance for EIF4ENIF1 Gene

Residual Variation Intolerance Score: 5.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4ENIF1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Disorders for EIF4ENIF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF4ENIF1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa, y-linked
  • rpy
  • convergence in manifest squint
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for EIF4ENIF1

genes like me logo Genes that share disorders with EIF4ENIF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4ENIF1 Gene

Publications for EIF4ENIF1 Gene

  1. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. (PMID: 10856257) Dostie J … Sonenberg N (The EMBO journal 2000) 2 3 4 22 58
  2. The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. (PMID: 19850929) Suzuki Y … Minami Y (The Journal of biological chemistry 2009) 3 22 58
  3. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PMID: 16699599) Wichroski MJ … Rana TM (PLoS pathogens 2006) 3 4 58
  4. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. (PMID: 16343815) Villaescusa JC … Verrotti AC (Gene 2006) 3 22 58
  5. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. (PMID: 16157702) Ferraiuolo MA … Sonenberg N (The Journal of cell biology 2005) 3 22 58

Products for EIF4ENIF1 Gene

Sources for EIF4ENIF1 Gene

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