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Aliases for WDR45B Gene

Aliases for WDR45B Gene

  • WD Repeat Domain 45B 2 3 5
  • WD Repeat-Containing Protein 45-Like 3 4
  • WD Repeat-Containing Protein 45B 3 4
  • WIPI49-Like Protein 3 4
  • WDR45-Like Protein 3 4
  • WDR45L 3 4
  • WIPI-3 3 4
  • WIPI3 3 4
  • WD Repeat Domain Phosphoinositide-Interacting Protein 3 3
  • WD Repeat Protein 45-Like 3
  • WIPI3 Long 3
  • WDR45-Like 2

External Ids for WDR45B Gene

Previous HGNC Symbols for WDR45B Gene

  • WDR45L

Previous GeneCards Identifiers for WDR45B Gene

  • GC17M080574

Summaries for WDR45B Gene

Entrez Gene Summary for WDR45B Gene

  • This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR45B Gene

WDR45B (WD Repeat Domain 45B) is a Protein Coding gene. Diseases associated with WDR45B include Neurodevelopmental Disorder With Spastic Quadriplegia And Brain Abnormalities With Or Without Seizures and Spastic Cerebral Palsy. Among its related pathways are Autophagy Pathway and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3-phosphate binding and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is WDR45.

Gene Wiki entry for WDR45B Gene

Additional gene information for WDR45B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR45B Gene

Genomics for WDR45B Gene

GeneHancer (GH) Regulatory Elements for WDR45B Gene

Promoters and enhancers for WDR45B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J082646 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 666.4 +0.3 332 3.4 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 WDR45B ENSG00000279613 TBCD GC17M082606
GH17J082492 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.4 +153.1 153060 6 CLOCK ZFP64 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 FOXK2 PIR58219 TRX-CAT1-8 GC17M082510 TBCD ENSG00000260563 ARL2BPP9 GPS1 NARF-IT1 HGS
GH17J082671 Enhancer 1 ENCODE dbSUPER 45.6 -22.6 -22607 0.2 ARNT ZNF473 ZNF493 NFRKB ZSCAN4 ZNF195 YBX1 PLRG1 ZNF207 KLF7 TBCD WDR45B OGFOD3 GPS1 HEXDC ENSG00000260563 ENSG00000263321 ENSG00000262652 ARL2BPP9 NARF-IT1
GH17J082590 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.5 +56.1 56081 3.5 PKNOX1 CLOCK ARNT NEUROD1 KLF17 SIN3A KLF5 ZBTB7B BRCA1 ZNF121 WDR45B TBCD GPS1 CCDC57 LOC101929552 FN3K RAB40B LOC105371942 ENSG00000261845 FOXK2
GH17J082095 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.1 +546.7 546743 13.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 FASN CEP131 CCDC57 TBCD HGS LOC105371942 ALYREF ARL2BPP9 ENSG00000262877 GPS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR45B on UCSC Golden Path with GeneCards custom track

Genomic Locations for WDR45B Gene

Genomic Locations for WDR45B Gene
33,992 bases
Minus strand
33,992 bases
Minus strand

Genomic View for WDR45B Gene

Genes around WDR45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR45B Gene

Proteins for WDR45B Gene

  • Protein details for WDR45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 3
    Protein Accession:
    Secondary Accessions:
    • O95328
    • Q2MCP6
    • Q6IBN2

    Protein attributes for WDR45B Gene

    344 amino acids
    Molecular mass:
    38122 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC72952.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR45B Gene

Post-translational modifications for WDR45B Gene

  • Ubiquitination at isoforms=278
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR45B Gene

Domains & Families for WDR45B Gene

Gene Families for WDR45B Gene

Protein Domains for WDR45B Gene

Suggested Antigen Peptide Sequences for WDR45B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat SVP1 family.
  • Belongs to the WD repeat SVP1 family.
genes like me logo Genes that share domains with WDR45B: view

Function for WDR45B Gene

Phenotypes From GWAS Catalog for WDR45B Gene

Gene Ontology (GO) - Molecular Function for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IBA --
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IBA --
genes like me logo Genes that share ontologies with WDR45B: view
genes like me logo Genes that share phenotypes with WDR45B: view

Animal Model Products

CRISPR Products

miRNA for WDR45B Gene

miRTarBase miRNAs that target WDR45B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR45B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR45B Gene

Localization for WDR45B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR45B gene
Compartment Confidence
cytosol 5
plasma membrane 2
golgi apparatus 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0019898 extrinsic component of membrane IBA --
GO:0034045 phagophore assembly site membrane IBA --
genes like me logo Genes that share ontologies with WDR45B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR45B Gene

Pathways & Interactions for WDR45B Gene

genes like me logo Genes that share pathways with WDR45B: view

Pathways by source for WDR45B Gene

2 Reactome pathways for WDR45B Gene

Gene Ontology (GO) - Biological Process for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 autophagy of mitochondrion IBA --
GO:0006497 protein lipidation IBA --
GO:0034497 protein localization to phagophore assembly site IBA --
GO:0044804 autophagy of nucleus IBA --
genes like me logo Genes that share ontologies with WDR45B: view

No data available for SIGNOR curated interactions for WDR45B Gene

Drugs & Compounds for WDR45B Gene

No Compound Related Data Available

Transcripts for WDR45B Gene

Unigene Clusters for WDR45B Gene

WD repeat domain 45B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR45B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR45B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP6: - -
SP7: - - - - -

Relevant External Links for WDR45B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR45B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR45B Gene

Protein differential expression in normal tissues from HIPED for WDR45B Gene

This gene is overexpressed in Breast (39.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR45B Gene

Protein tissue co-expression partners for WDR45B Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR45B Gene:


SOURCE GeneReport for Unigene cluster for WDR45B Gene:


mRNA Expression by UniProt/SwissProt for WDR45B Gene:

Tissue specificity: Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers.
genes like me logo Genes that share expression patterns with WDR45B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR45B Gene

Orthologs for WDR45B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR45B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR45L 34 33
  • 99.61 (n)
(Monodelphis domestica)
Mammalia WDR45B 34
  • 98 (a)
(Bos Taurus)
Mammalia WDR45L 34 33
  • 92.15 (n)
(Canis familiaris)
Mammalia WDR45B 34 33
  • 91.72 (n)
(Mus musculus)
Mammalia Wdr45b 16 34 33
  • 90.99 (n)
(Rattus norvegicus)
Mammalia Wdr45b 33
  • 90.21 (n)
(Ornithorhynchus anatinus)
Mammalia WDR45B 34
  • 88 (a)
(Gallus gallus)
Aves WDR45B 34
  • 97 (a)
WDR45L 33
  • 87.5 (n)
(Anolis carolinensis)
Reptilia WDR45B 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr45b 33
  • 82.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5528 33
(Danio rerio)
Actinopterygii wdr45l 34 33
  • 80.23 (n)
zgc56002 33
fruit fly
(Drosophila melanogaster)
Insecta CG11975 34 33
  • 64.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012792 33
  • 64.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSV2 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG18C 33
  • 51.15 (n)
(Oryza sativa)
Liliopsida Os01g0168500 33
  • 54.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
Cin.576 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.576 33
Species where no ortholog for WDR45B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR45B Gene

Gene Tree for WDR45B (if available)
Gene Tree for WDR45B (if available)
Evolutionary constrained regions (ECRs) for WDR45B: view image

Paralogs for WDR45B Gene

Paralogs for WDR45B Gene

(3) SIMAP similar genes for WDR45B Gene using alignment to 5 proteins:

  • I3L1D0_HUMAN
  • I3L3A5_HUMAN
  • I3L4L8_HUMAN
  • I3L4S6_HUMAN Pseudogenes for WDR45B Gene

genes like me logo Genes that share paralogs with WDR45B: view

Variants for WDR45B Gene

Sequence variations from dbSNP and Humsavar for WDR45B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs786205510 likely-pathogenic, not provided 82,619,074(-) G/A coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs1000075676 -- 82,618,738(-) T/C intron_variant
rs1000235333 -- 82,623,761(-) T/C intron_variant
rs1000377304 -- 82,634,690(-) C/T intron_variant
rs1000434233 -- 82,628,703(-) ACACACA/ACACA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR45B Gene

Variant ID Type Subtype PubMed ID
esv1010132 CNV insertion 20482838
esv1510304 CNV insertion 17803354
esv21913 CNV gain+loss 19812545
esv2668610 CNV deletion 23128226
esv2675908 CNV deletion 23128226
esv2716511 CNV deletion 23290073
esv2716512 CNV deletion 23290073
esv2762577 CNV gain+loss 21179565
esv3448719 CNV insertion 20981092
esv3641433 CNV loss 21293372
esv3641435 CNV loss 21293372
nsv1062980 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv1067362 CNV gain 25217958
nsv1067553 CNV loss 25217958
nsv428351 CNV gain 18775914

Variation tolerance for WDR45B Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR45B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR45B Gene

Disorders for WDR45B Gene

MalaCards: The human disease database

(2) MalaCards diseases for WDR45B Gene - From: HGMD, OMIM, ClinVar, and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for WDR45B

genes like me logo Genes that share disorders with WDR45B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR45B Gene

Publications for WDR45B Gene

  1. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PMID: 15602573) Proikas-Cezanne T … Nordheim A (Oncogene 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. (PMID: 28561066) Bakula D … Proikas-Cezanne T (Nature communications 2017) 3 58
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58

Products for WDR45B Gene

Sources for WDR45B Gene

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