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Aliases for CPXM1 Gene

Aliases for CPXM1 Gene

  • Carboxypeptidase X, M14 Family Member 1 2 3 5
  • Carboxypeptidase X (M14 Family), Member 1 2 3
  • Carboxypeptidase-Like Protein X1 2 3
  • Metallocarboxypeptidase CPX-1 3 4
  • CPX1 3 4
  • CPXM 3 4
  • Probable Carboxypeptidase X1 3
  • EC 56
  • EC 56
  • EC 3.4.17.- 4
  • EC 3.4.17 56

External Ids for CPXM1 Gene

Previous HGNC Symbols for CPXM1 Gene

  • CPXM

Summaries for CPXM1 Gene

Entrez Gene Summary for CPXM1 Gene

  • This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]

GeneCards Summary for CPXM1 Gene

CPXM1 (Carboxypeptidase X, M14 Family Member 1) is a Protein Coding gene. Diseases associated with CPXM1 include Simpson-Golabi-Behmel Syndrome. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPXM2.

UniProtKB/Swiss-Prot for CPXM1 Gene

  • May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Gene Wiki entry for CPXM1 Gene

Additional gene information for CPXM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPXM1 Gene

Genomics for CPXM1 Gene

GeneHancer (GH) Regulatory Elements for CPXM1 Gene

Promoters and enhancers for CPXM1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I002798 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 560.1 +0.6 599 2.8 HDAC1 TCF12 GATA2 ZNF143 NCOA1 REST ZEB2 NFIC KLF16 SMARCA4 CPXM1 GC20M002790 RPL19P1
GH20I002768 Enhancer 0.6 ENCODE 27.7 +32.1 32056 1.2 SMARCE1 ESRRA ZNF687 HCFC1 RXRA NFIB ZNF449 DPF2 ELF1 RAD21 CPXM1 VPS16 PTPRA ENSG00000241690 C20orf141 TMEM239 PCED1A PIR31974 RPL19P1
GH20I002818 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.3 -19.6 -19634 3.4 FEZF1 HIC1 ZNF335 ZFHX2 GLIS2 ZNF316 PRDM10 MAFK EGR2 EZH2 CPXM1 VPS16 TMEM239 GC20P002876
GH20I002813 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 5.1 -14.4 -14393 2.1 KLF1 TAL1 KLF17 ZIC2 ZNF335 TCF12 ZNF366 NCOR1 ZBTB48 PATZ1 TMEM239 ENSG00000241690 C20orf141 CPXM1 VPS16
GH20I002816 Promoter 0.6 EPDnew 8.2 -15.7 -15699 0.1 PRDM1 ENSG00000241690 TMEM239 C20orf141 CPXM1 GC20P002876
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPXM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPXM1 gene promoter:

Genomic Locations for CPXM1 Gene

Genomic Locations for CPXM1 Gene
6,578 bases
Minus strand

Genomic View for CPXM1 Gene

Genes around CPXM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPXM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPXM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPXM1 Gene

Proteins for CPXM1 Gene

  • Protein details for CPXM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable carboxypeptidase X1
    Protein Accession:
    Secondary Accessions:
    • Q6P4G8
    • Q6UW65
    • Q9NUB5

    Protein attributes for CPXM1 Gene

    734 amino acids
    Molecular mass:
    81668 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for CPXM1 Gene

Selected DME Specific Peptides for CPXM1 Gene


Post-translational modifications for CPXM1 Gene

  • Glycosylation at posLast=5757, Asn210, Asn220, Asn318, posLast=428428, and Asn472
  • Modification sites at PhosphoSitePlus

Other Protein References for CPXM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPXM1 Gene

Gene Families for CPXM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPXM1: view

Function for CPXM1 Gene

Molecular function for CPXM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Enzyme Numbers (IUBMB) for CPXM1 Gene

Phenotypes From GWAS Catalog for CPXM1 Gene

Gene Ontology (GO) - Molecular Function for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 NOT metallocarboxypeptidase activity IBA --
GO:0004185 NOT serine-type carboxypeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPXM1: view
genes like me logo Genes that share phenotypes with CPXM1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPXM1 Gene

Localization for CPXM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPXM1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPXM1 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with CPXM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPXM1 Gene

Pathways & Interactions for CPXM1 Gene

SuperPathways for CPXM1 Gene

No Data Available

Interacting Proteins for CPXM1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: Q96SM3-CPXM1_HUMAN ENSP00000369979 for CPXM1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 NOT peptide metabolic process IBA --
GO:0016485 NOT protein processing IBA --
genes like me logo Genes that share ontologies with CPXM1: view

No data available for Pathways by source and SIGNOR curated interactions for CPXM1 Gene

Drugs & Compounds for CPXM1 Gene

No Compound Related Data Available

Transcripts for CPXM1 Gene

mRNA/cDNA for CPXM1 Gene

Unigene Clusters for CPXM1 Gene

Carboxypeptidase X (M14 family), member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPXM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for CPXM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPXM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPXM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPXM1 Gene

This gene is overexpressed in Cervix - Ectocervix (x7.1), Adipose - Visceral (Omentum) (x5.8), Uterus (x5.2), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for CPXM1 Gene

This gene is overexpressed in Uterus (13.1), Placenta (12.3), Gallbladder (7.6), Ovary (7.5), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPXM1 Gene

Protein tissue co-expression partners for CPXM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPXM1 Gene:


SOURCE GeneReport for Unigene cluster for CPXM1 Gene:


Evidence on tissue expression from TISSUES for CPXM1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CPXM1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPXM1 Gene

Orthologs for CPXM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPXM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPXM1 33 34
  • 97.12 (n)
(Bos Taurus)
Mammalia CPXM1 33 34
  • 88.04 (n)
(Canis familiaris)
Mammalia CPXM1 33 34
  • 86.64 (n)
(Mus musculus)
Mammalia Cpxm1 33 16 34
  • 84.21 (n)
(Rattus norvegicus)
Mammalia Cpxm1 33
  • 83.84 (n)
(Ornithorhynchus anatinus)
Mammalia CPXM1 34
  • 79 (a)
(Monodelphis domestica)
Mammalia CPXM1 34
  • 76 (a)
(Gallus gallus)
Aves CPXM1 34
  • 65 (a)
(Anolis carolinensis)
Reptilia CPXM1 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpxm1 33
  • 65.83 (n)
Str.17581 33
(Danio rerio)
Actinopterygii si:dkey-19p15.7 33
  • 64.24 (n)
CPXM1 (1 of 2) 34
  • 55 (a)
CU469518.1 34
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for CPXM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPXM1 Gene

Gene Tree for CPXM1 (if available)
Gene Tree for CPXM1 (if available)

Paralogs for CPXM1 Gene

Paralogs for CPXM1 Gene

(7) SIMAP similar genes for CPXM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPXM1: view

Variants for CPXM1 Gene

Sequence variations from dbSNP and Humsavar for CPXM1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000138124 -- 2,799,536(-) C/T intron_variant
rs1000321194 -- 2,799,113(-) G/C intron_variant
rs1000372240 -- 2,794,116(-) G/A 3_prime_UTR_variant
rs1000654985 -- 2,797,830(-) C/A/T intron_variant
rs1001086455 -- 2,795,540(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPXM1 Gene

Variant ID Type Subtype PubMed ID
esv2762056 CNV gain 21179565
nsv1057464 CNV gain 25217958
nsv510780 CNV deletion 20534489
nsv522009 CNV gain 19592680
nsv833895 CNV loss 17160897
nsv952977 CNV deletion 24416366

Variation tolerance for CPXM1 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPXM1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPXM1 Gene

Disorders for CPXM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPXM1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
simpson-golabi-behmel syndrome
  • sgbs1
- elite association - COSMIC cancer census association via MalaCards
Search CPXM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPXM1

genes like me logo Genes that share disorders with CPXM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPXM1 Gene

Publications for CPXM1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding glycoprotein. (PMID: 26603934) Kim YH … Whitehead JP (Biochemical and biophysical research communications 2015) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for CPXM1 Gene

Sources for CPXM1 Gene

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