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Aliases for TMX4 Gene

Aliases for TMX4 Gene

  • Thioredoxin Related Transmembrane Protein 4 2 3 5
  • Protein Disulfide Isomerase Family A, Member 14 2 3
  • Thioredoxin-Related Transmembrane Protein 4 2 3
  • Thioredoxin Domain-Containing Protein 13 3 4
  • Thioredoxin Domain Containing 13 2 3
  • TXNDC13 3 4
  • DJ971N18.2 3
  • KIAA1162 4
  • PDIA14 3

External Ids for TMX4 Gene

Previous HGNC Symbols for TMX4 Gene

  • TXNDC13

Summaries for TMX4 Gene

Entrez Gene Summary for TMX4 Gene

  • This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]

GeneCards Summary for TMX4 Gene

TMX4 (Thioredoxin Related Transmembrane Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein disulfide isomerase activity. An important paralog of this gene is TMX1.

Gene Wiki entry for TMX4 Gene

Additional gene information for TMX4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX4 Gene

Genomics for TMX4 Gene

GeneHancer (GH) Regulatory Elements for TMX4 Gene

Promoters and enhancers for TMX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J008018 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 664.6 0.0 -10 2.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF213 TMX4 LOC105372520 GC20P008028
GH20J008722 Enhancer 0.8 ENCODE 11.1 -702.7 -702670 0.2 DRAP1 ELF3 CTCF ARID4B EBF1 ZNF384 KDM3A RAD21 RELA TEAD3 LOC105372520 TMX4 LOC105372521 GC20P008831 RNU105B PLCB1
GH20J008129 Enhancer 0.8 ENCODE 10.5 -110.0 -109980 0.1 ELF3 FOXA2 RARA ZNF614 ATF7 CEBPB NFYC ZHX2 NFIL3 ATF4 TMX4 LOC105372520 PHKBP1 PLCB1 GC20M008185
GH20J008130 Enhancer 0.7 ENCODE 10.5 -109.9 -109890 0 ELF3 FOXA2 SAP130 CEBPG ZNF644 RBPJ ZNF614 IKZF5 ATF7 NR2F6 TMX4 LOC105372520 PHKBP1 PLCB1 GC20M008185
GH20J008427 Enhancer 0.8 FANTOM5 Ensembl ENCODE 8.5 -408.1 -408075 1 HLF NR2F2 PLCB1 TMX4 GC20P008366 GC20M008621
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMX4 gene promoter:
  • HFH-3
  • FOXI1
  • Nkx2-2
  • C/EBPalpha
  • ZID
  • HNF-1
  • HNF-1A
  • LCR-F1
  • LHX3b
  • Lhx3a

Genomic Locations for TMX4 Gene

Genomic Locations for TMX4 Gene
42,482 bases
Minus strand
42,482 bases
Minus strand

Genomic View for TMX4 Gene

Genes around TMX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX4 Gene

Proteins for TMX4 Gene

  • Protein details for TMX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin-related transmembrane protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8N4P7
    • Q8NCC1
    • Q9UJA1
    • Q9ULQ8

    Protein attributes for TMX4 Gene

    349 amino acids
    Molecular mass:
    38952 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB56344.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMX4 Gene

Post-translational modifications for TMX4 Gene

  • Ubiquitination at posLast=115115
  • Modification sites at PhosphoSitePlus

Other Protein References for TMX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for TMX4

No data available for DME Specific Peptides for TMX4 Gene

Domains & Families for TMX4 Gene

Gene Families for TMX4 Gene

Protein Domains for TMX4 Gene

Suggested Antigen Peptide Sequences for TMX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMX4: view

No data available for UniProtKB/Swiss-Prot for TMX4 Gene

Function for TMX4 Gene

Gene Ontology (GO) - Molecular Function for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
genes like me logo Genes that share ontologies with TMX4: view
genes like me logo Genes that share phenotypes with TMX4: view

Animal Model Products

Clone Products

  • Addgene plasmids for TMX4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMX4 Gene

Localization for TMX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMX4 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX4: view

Pathways & Interactions for TMX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TMX4: view

No data available for Pathways by source and SIGNOR curated interactions for TMX4 Gene

Drugs & Compounds for TMX4 Gene

No Compound Related Data Available

Transcripts for TMX4 Gene

mRNA/cDNA for TMX4 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(413) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMX4 Gene

Thioredoxin-related transmembrane protein 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for TMX4

Alternative Splicing Database (ASD) splice patterns (SP) for TMX4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: -
SP4: - -
SP5: - - - -

Relevant External Links for TMX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMX4 Gene

Protein differential expression in normal tissues from HIPED for TMX4 Gene

This gene is overexpressed in Nasal epithelium (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMX4 Gene

Protein tissue co-expression partners for TMX4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMX4 Gene:


SOURCE GeneReport for Unigene cluster for TMX4 Gene:


Evidence on tissue expression from TISSUES for TMX4 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(2.9)
  • Heart(2)
genes like me logo Genes that share expression patterns with TMX4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMX4 Gene

Orthologs for TMX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMX4 34 33
  • 99.14 (n)
(Canis familiaris)
Mammalia TMX4 34 33
  • 86.67 (n)
(Bos Taurus)
Mammalia TMX4 34 33
  • 86.63 (n)
-- 34
  • 63 (a)
(Rattus norvegicus)
Mammalia Tmx4 33
  • 84.44 (n)
(Mus musculus)
Mammalia Tmx4 16 34 33
  • 83.78 (n)
(Monodelphis domestica)
Mammalia TMX4 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TMX4 34
  • 49 (a)
(Gallus gallus)
Aves TMX4 34 33
  • 65.2 (n)
(Anolis carolinensis)
Reptilia TMX4 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmx4 33
  • 64.64 (n)
Str.19537 33
(Danio rerio)
Actinopterygii tmx4 34 33
  • 57.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5554 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea dpy-11 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for TMX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX4 Gene

Gene Tree for TMX4 (if available)
Gene Tree for TMX4 (if available)
Evolutionary constrained regions (ECRs) for TMX4: view image

Paralogs for TMX4 Gene

Paralogs for TMX4 Gene

(2) SIMAP similar genes for TMX4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMX4: view

Variants for TMX4 Gene

Sequence variations from dbSNP and Humsavar for TMX4 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000104146 -- 7,989,422(-) A/T intron_variant
rs1000337228 -- 8,007,822(-) T/A intron_variant
rs1000355043 -- 7,991,726(-) A/G intron_variant
rs1000613398 -- 7,985,237(-) G/A intron_variant
rs1000686447 -- 7,990,277(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMX4 Gene

Variant ID Type Subtype PubMed ID
esv2422203 CNV duplication 17116639
esv3584438 CNV loss 25503493
esv3893279 CNV gain 25118596
nsv1059059 CNV gain 25217958
nsv585384 CNV gain 21841781

Variation tolerance for TMX4 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMX4 Gene

Disorders for TMX4 Gene

Additional Disease Information for TMX4

No disorders were found for TMX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMX4 Gene

Publications for TMX4 Gene

  1. Novel thioredoxin-related transmembrane protein TMX4 has reductase activity. (PMID: 20056998) Sugiura Y … Nagata K (The Journal of biological chemistry 2010) 2 3 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for TMX4 Gene

Sources for TMX4 Gene

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