Aliases for BTNL2 Gene
External Ids for BTNL2 Gene
Previous GeneCards Identifiers for BTNL2 Gene
This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]
GeneCards Summary for BTNL2 Gene
BTNL2 (Butyrophilin Like 2) is a Protein Coding gene. Diseases associated with BTNL2 include Sarcoidosis 2 and Sarcoidosis 1. Among its related pathways are Innate Immune System and Butyrophilin (BTN) family interactions. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is BTN1A1.
UniProtKB/Swiss-Prot for BTNL2 Gene
Negative regulator of T-cell proliferation.