Aliases for MAP2K5 Gene
External Ids for MAP2K5 Gene
Previous HGNC Symbols for MAP2K5 Gene
Previous GeneCards Identifiers for MAP2K5 Gene
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
GeneCards Summary for MAP2K5 Gene
MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP2K5 include Caroli Disease and Restless Legs Syndrome. Among its related pathways are Oxytocin signaling pathway and MicroRNAs in cardiomyocyte hypertrophy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K1.
UniProtKB/Swiss-Prot Summary for MAP2K5 Gene
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.