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Aliases for SLC50A1 Gene

Aliases for SLC50A1 Gene

  • Solute Carrier Family 50 Member 1 2 3 4 5
  • Stromal Cell Protein 2 3 4
  • Solute Carrier Family 50 (Sugar Efflux Transporter), Member 1 2 3
  • Recombination Activating Gene 1 Activating Protein 1 2 3
  • RAG1-Activating Protein 1 3 4
  • HsSWEET1 3 4
  • RAG1AP1 3 4
  • SCP 3 4
  • Solute Carrier Family 50 (Sugar Transporter), Member 1 3
  • Probable Sugar Transporter RAG1AP1 3
  • Sugar Transporter SWEET1 3
  • RP11-540D14.5 3
  • RZPDo834D038D 3
  • SWEET1 3
  • Slv 3

External Ids for SLC50A1 Gene

Previous HGNC Symbols for SLC50A1 Gene

  • RAG1AP1

Previous GeneCards Identifiers for SLC50A1 Gene

  • GC01P155110

Summaries for SLC50A1 Gene

GeneCards Summary for SLC50A1 Gene

SLC50A1 (Solute Carrier Family 50 Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include glucoside transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC50A1 Gene

  • Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.

Additional gene information for SLC50A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC50A1 Gene

Genomics for SLC50A1 Gene

GeneHancer (GH) Regulatory Elements for SLC50A1 Gene

Promoters and enhancers for SLC50A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J155132 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 147 5.3 CLOCK MLX DMAP1 YY1 E2F8 ZNF143 SP3 SSRP1 NBN NR2C1 SLC50A1 GBAP1 SYT11 LOC101928120 ENSG00000231064 TRIM46 ASH1L-AS1 YY1AP1 DCST1-AS1 ADAM15
GH01J154998 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.6 -130.9 -130893 11.3 CLOCK MLX YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 ZBTB7B GON4L CLK2 UBAP2L KHDC4 ENSG00000271267 THBS3 RUSC1-AS1 SHC1 MSTO1
GH01J155242 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 18.7 +108.9 108898 2.9 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GBA GON4L KHDC4 CLK2 ENSG00000271267 MSTO1 MSTO2P RUSC1-AS1 THBS3 SHC1
GH01J154965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.4 -163.3 -163290 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 SHC1 CKS1B UBAP2L GON4L CLK2 KHDC4 THBS3 YY1AP1 KRTCAP2 ENSG00000271267
GH01J154351 Enhancer 1.5 Ensembl ENCODE dbSUPER 18.5 -782.2 -782160 3.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B DMAP1 YY1 ZNF766 PIR58101 CLK2 UBAP2L CHTOP CRTC2 RUSC1-AS1 SLC27A3 ILF2 FLAD1 CREB3L4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC50A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC50A1 Gene

Genomic Locations for SLC50A1 Gene
chr1:155,135,344-155,138,858
(GRCh38/hg38)
Size:
3,515 bases
Orientation:
Plus strand
chr1:155,107,820-155,111,334
(GRCh37/hg19)
Size:
3,515 bases
Orientation:
Plus strand

Genomic View for SLC50A1 Gene

Genes around SLC50A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC50A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC50A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC50A1 Gene

Proteins for SLC50A1 Gene

  • Protein details for SLC50A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRV3-SWET1_HUMAN
    Recommended name:
    Sugar transporter SWEET1
    Protein Accession:
    Q9BRV3
    Secondary Accessions:
    • Q5SR64
    • Q6IAK6
    • Q96DC5
    • Q9UHQ2
    • Q9UHQ3

    Protein attributes for SLC50A1 Gene

    Size:
    221 amino acids
    Molecular mass:
    25030 Da
    Quaternary structure:
    • Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.

    Alternative splice isoforms for SLC50A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC50A1 Gene

Post-translational modifications for SLC50A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC50A1 Gene

Domains & Families for SLC50A1 Gene

Gene Families for SLC50A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC50A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC50A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRV3

UniProtKB/Swiss-Prot:

SWET1_HUMAN :
  • Belongs to the SWEET sugar transporter family.
Family:
  • Belongs to the SWEET sugar transporter family.
genes like me logo Genes that share domains with SLC50A1: view

Function for SLC50A1 Gene

Molecular function for SLC50A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.

Phenotypes From GWAS Catalog for SLC50A1 Gene

Gene Ontology (GO) - Molecular Function for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042947 glucoside transmembrane transporter activity IDA 21107422
GO:0051119 sugar transmembrane transporter activity IBA,TAS --
genes like me logo Genes that share ontologies with SLC50A1: view
genes like me logo Genes that share phenotypes with SLC50A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC50A1

CRISPR Products

miRNA for SLC50A1 Gene

miRTarBase miRNAs that target SLC50A1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC50A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC50A1 Gene

Localization for SLC50A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC50A1 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=May also localize to the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC50A1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
nucleus 3

Gene Ontology (GO) - Cellular Components for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IC 8630032
GO:0005794 Golgi apparatus IEA,IDA 21107422
GO:0005886 plasma membrane TAS --
GO:0012505 endomembrane system ISS --
genes like me logo Genes that share ontologies with SLC50A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC50A1 Gene

Pathways & Interactions for SLC50A1 Gene

genes like me logo Genes that share pathways with SLC50A1: view

Pathways by source for SLC50A1 Gene

Gene Ontology (GO) - Biological Process for SLC50A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA,IBA --
GO:0008645 hexose transmembrane transport TAS --
GO:0042946 glucoside transport IEA --
GO:0045815 positive regulation of gene expression, epigenetic ISS 8630032
genes like me logo Genes that share ontologies with SLC50A1: view

No data available for SIGNOR curated interactions for SLC50A1 Gene

Drugs & Compounds for SLC50A1 Gene

No Compound Related Data Available

Transcripts for SLC50A1 Gene

Unigene Clusters for SLC50A1 Gene

Solute carrier family 50 (sugar transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC50A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC50A1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:

Relevant External Links for SLC50A1 Gene

GeneLoc Exon Structure for
SLC50A1
ECgene alternative splicing isoforms for
SLC50A1

Expression for SLC50A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC50A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC50A1 Gene

This gene is overexpressed in Adrenal (32.8) and Platelet (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC50A1 Gene



Protein tissue co-expression partners for SLC50A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC50A1 Gene:

SLC50A1

SOURCE GeneReport for Unigene cluster for SLC50A1 Gene:

Hs.292154

mRNA Expression by UniProt/SwissProt for SLC50A1 Gene:

Q9BRV3-SWET1_HUMAN
Tissue specificity: Ubiquitously expressed with highest expression in oviduct, epididymis and intestine.

Evidence on tissue expression from TISSUES for SLC50A1 Gene

  • Adrenal gland(4.3)
  • Pancreas(4.3)
  • Nervous system(4.2)
  • Liver(2.7)
  • Heart(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with SLC50A1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC50A1 Gene

Orthologs for SLC50A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC50A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC50A1 34 33
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC50A1 34 33
  • 87.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC50A1 33
  • 85.82 (n)
RAG1AP1 34
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc50a1 33
  • 84.01 (n)
mouse
(Mus musculus)
Mammalia Slc50a1 16 34 33
  • 82.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC50A1 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc50a1 33
  • 66.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5895 33
zebrafish
(Danio rerio)
Actinopterygii slc50a1 34 33
  • 59.82 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005236 33
  • 43.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta slv 34 33
  • 42.41 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swt-1 34 33
  • 42.86 (n)
OneToMany
swt-4 34
  • 23 (a)
OneToMany
swt-2 34
  • 21 (a)
OneToMany
swt-3 34
  • 17 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50790 33
  • 42.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10502 34
  • 33 (a)
OneToOne
Species where no ortholog for SLC50A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC50A1 Gene

ENSEMBL:
Gene Tree for SLC50A1 (if available)
TreeFam:
Gene Tree for SLC50A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC50A1: view image

Paralogs for SLC50A1 Gene

No data available for Paralogs for SLC50A1 Gene

Variants for SLC50A1 Gene

Sequence variations from dbSNP and Humsavar for SLC50A1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000730338 -- 155,134,216(+) G/A upstream_transcript_variant
rs1002288135 -- 155,137,830(+) A/G intron_variant
rs1003065339 -- 155,135,306(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1004242313 -- 155,135,106(+) C/T upstream_transcript_variant
rs1005207619 -- 155,134,806(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC50A1 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv464084 CNV loss 19166990
nsv509502 CNV insertion 20534489
nsv547961 CNV loss 21841781
nsv998756 CNV gain 25217958

Variation tolerance for SLC50A1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC50A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC50A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC50A1 Gene

Disorders for SLC50A1 Gene

Additional Disease Information for SLC50A1

No disorders were found for SLC50A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC50A1 Gene

Publications for SLC50A1 Gene

  1. Sugar transporters for intercellular exchange and nutrition of pathogens. (PMID: 21107422) Chen LQ … Frommer WB (Nature 2010) 2 3 4 58
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 58
  3. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N … PD GWAS Consortium (Annals of neurology 2012) 3 58
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for SLC50A1 Gene

Sources for SLC50A1 Gene

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