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Aliases for RCC2 Gene

Aliases for RCC2 Gene

  • Regulator Of Chromosome Condensation 2 2 3 5
  • Telophase Disk Protein Of 60 KDa 3 4
  • RCC1-Like Protein TD-60 3 4
  • Protein RCC2 3
  • KIAA1470 4
  • TD-60 3
  • TD60 4

External Ids for RCC2 Gene

Previous GeneCards Identifiers for RCC2 Gene

  • GC01M017479
  • GC01M017605
  • GC01M017733
  • GC01M015979

Summaries for RCC2 Gene

Entrez Gene Summary for RCC2 Gene

  • The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]

GeneCards Summary for RCC2 Gene

RCC2 (Regulator Of Chromosome Condensation 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is RPGR.

UniProtKB/Swiss-Prot for RCC2 Gene

  • Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Gene Wiki entry for RCC2 Gene

Additional gene information for RCC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCC2 Gene

Genomics for RCC2 Gene

GeneHancer (GH) Regulatory Elements for RCC2 Gene

Promoters and enhancers for RCC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J017431 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.9 1864 13.2 HDGF HNRNPUL1 PKNOX1 SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 RCC2 PADI6 ENSG00000226526 MFAP2 PIR50299 GC01M017408
GH01J016902 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 18 +534.7 534704 4.9 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000272426 ZBTB17 CROCC CROCCP3 ARHGEF19 RPL22P3 LINC01772 MFAP2 NECAP2 SZRD1
GH01J016498 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +940.7 940683 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 GTF3C2 ZNF121 GLIS2 ZNF213 CROCCP3 ENSG00000237938 NECAP2 ARHGEF19 SPATA21 SPEN RPS16P1 ENSG00000224621 DDI2 RCC2
GH01J016894 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10 +543.6 543569 2.8 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 YY1 RNU1-2 ZBTB17 ARHGEF19 CROCC NECAP2 RPL22P3 CROCCP3 SZRD1 LINC01772 MFAP2
GH01J016706 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.7 +732.5 732539 2.2 ATF1 ZNF133 SIN3A GLI4 ZNF2 ZBTB7B ZNF48 ZNF121 GLIS2 ZNF213 ZBTB17 CROCC CROCCP3 LINC01772 SPEN NECAP2 RCC2 MST1L ESPNP CROCCP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RCC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RCC2 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • AML1a
  • Chx10
  • CP1A
  • CBF-B

Genomic Locations for RCC2 Gene

Genomic Locations for RCC2 Gene
33,000 bases
Minus strand
32,970 bases
Minus strand

Genomic View for RCC2 Gene

Genes around RCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCC2 Gene

Proteins for RCC2 Gene

  • Protein details for RCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RCC2
    Protein Accession:
    Secondary Accessions:
    • Q8IVL9
    • Q9BSN6
    • Q9NPV8

    Protein attributes for RCC2 Gene

    522 amino acids
    Molecular mass:
    56085 Da
    Quaternary structure:
    • Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.
    • Sequence=BAA95994.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB94882.1; Type=Frameshift; Positions=477; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCC2 Gene

neXtProt entry for RCC2 Gene

Post-translational modifications for RCC2 Gene

  • Ubiquitination at Lys377, Lys349, Lys320, and Lys92
  • Modification sites at PhosphoSitePlus

Other Protein References for RCC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCC2 Gene

Domains & Families for RCC2 Gene

Gene Families for RCC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RCC2 Gene

Suggested Antigen Peptide Sequences for RCC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RCC2: view

No data available for UniProtKB/Swiss-Prot for RCC2 Gene

Function for RCC2 Gene

Molecular function for RCC2 Gene

UniProtKB/Swiss-Prot Function:
Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

Phenotypes From GWAS Catalog for RCC2 Gene

Gene Ontology (GO) - Molecular Function for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 22282019
GO:0008017 microtubule binding IMP 12919680
GO:0019901 protein kinase binding IPI 25074804
GO:0019904 protein domain specific binding IPI 25074804
genes like me logo Genes that share ontologies with RCC2: view
genes like me logo Genes that share phenotypes with RCC2: view

Animal Models for RCC2 Gene

MGI Knock Outs for RCC2:
  • Rcc2 Rcc2<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for RCC2 Gene

miRTarBase miRNAs that target RCC2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RCC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCC2 Gene

Localization for RCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCC2 Gene

Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
endosome 2

Gene Ontology (GO) - Cellular Components for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with RCC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RCC2 Gene

Pathways & Interactions for RCC2 Gene

genes like me logo Genes that share pathways with RCC2: view

Pathways by source for RCC2 Gene

2 Cell Signaling Technology pathways for RCC2 Gene

Gene Ontology (GO) - Biological Process for RCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007229 integrin-mediated signaling pathway IDA 19738201
GO:0010762 regulation of fibroblast migration IEA --
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP 12919680
genes like me logo Genes that share ontologies with RCC2: view

No data available for SIGNOR curated interactions for RCC2 Gene

Drugs & Compounds for RCC2 Gene

(3) Drugs for RCC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RCC2: view

Transcripts for RCC2 Gene

mRNA/cDNA for RCC2 Gene

Unigene Clusters for RCC2 Gene

Regulator of chromosome condensation 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RCC2

Alternative Splicing Database (ASD) splice patterns (SP) for RCC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15
SP2: - -

Relevant External Links for RCC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RCC2 Gene

This gene is overexpressed in Lymph node (14.6), Peripheral blood mononuclear cells (9.4), Amniocyte (8.5), and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RCC2 Gene

Protein tissue co-expression partners for RCC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RCC2 Gene:


SOURCE GeneReport for Unigene cluster for RCC2 Gene:


Evidence on tissue expression from TISSUES for RCC2 Gene

  • Nervous system(4.5)
  • Blood(4.3)
  • Muscle(4.1)
  • Skin(3.3)
  • Intestine(2.4)
  • Stomach(2.4)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with RCC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCC2 Gene

Orthologs for RCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RCC2 34 33
  • 99.3 (n)
(Ornithorhynchus anatinus)
Mammalia RCC2 34
  • 97 (a)
(Monodelphis domestica)
Mammalia RCC2 34
  • 96 (a)
(Canis familiaris)
Mammalia RCC2 34 33
  • 91.88 (n)
(Bos Taurus)
Mammalia RCC2 34 33
  • 90.77 (n)
(Mus musculus)
Mammalia Rcc2 16 34 33
  • 87.69 (n)
(Rattus norvegicus)
Mammalia Rcc2 33
  • 86.96 (n)
(Gallus gallus)
Aves RCC2 34 33
  • 83.61 (n)
(Anolis carolinensis)
Reptilia RCC2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494942 33
  • 78.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7388 33
(Danio rerio)
Actinopterygii rcc2 34 33
  • 72.37 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8430 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002151 33
  • 54.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9135 34 33
  • 52.74 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G19880 33
  • 48.52 (n)
(Oryza sativa)
Liliopsida Os04g0662800 33
  • 47.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2242 34
  • 50 (a)
Species where no ortholog for RCC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCC2 Gene

Gene Tree for RCC2 (if available)
Gene Tree for RCC2 (if available)
Evolutionary constrained regions (ECRs) for RCC2: view image

Paralogs for RCC2 Gene

Variants for RCC2 Gene

Sequence variations from dbSNP and Humsavar for RCC2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs864622010 uncertain-significance, Malignant tumor of prostate 17,420,791(-) C/G coding_sequence_variant, missense_variant
rs1000120645 -- 17,425,498(-) G/C intron_variant
rs1000238836 -- 17,410,356(-) A/G intron_variant
rs1000279124 -- 17,436,705(-) A/G intron_variant
rs1000365810 -- 17,416,227(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RCC2 Gene

Variant ID Type Subtype PubMed ID
dgv53n106 CNV deletion 24896259
nsv1075665 CNV deletion 25765185
nsv821932 CNV gain 20364138
nsv945802 CNV duplication 23825009

Variation tolerance for RCC2 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RCC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCC2 Gene

Disorders for RCC2 Gene

Additional Disease Information for RCC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RCC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCC2 Gene

Publications for RCC2 Gene

  1. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. (PMID: 12919680) Mollinari C … Margolis RL (Developmental cell 2003) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PMID: 18849993) Stacey SN … Stefansson K (Nature genetics 2008) 3 44 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RCC2 Gene

Sources for RCC2 Gene

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