Aliases for HDAC8 Gene
External Ids for HDAC8 Gene
Previous HGNC Symbols for HDAC8 Gene
Previous GeneCards Identifiers for HDAC8 Gene
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for HDAC8 Gene
HDAC8 (Histone Deacetylase 8) is a Protein Coding gene. Diseases associated with HDAC8 include Cornelia De Lange Syndrome 5 and Wilson-Turner X-Linked Mental Retardation Syndrome. Among its related pathways are Notch signaling pathway (KEGG) and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include transcription factor binding and NAD-dependent histone deacetylase activity (H3-K9 specific). An important paralog of this gene is HDAC1.
UniProtKB/Swiss-Prot for HDAC8 Gene
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze acetyl group removal from lysine residues in histones and non-histone proteins, causing transcriptional repression. HDACs are usually components of multiprotein complexes.