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Aliases for ZNF83 Gene

Aliases for ZNF83 Gene

  • Zinc Finger Protein 83 2 3 3 5
  • Zinc Finger Protein 816B 2 3 4
  • Zinc Finger Protein HPF1 3 4
  • ZNF816B 3 4
  • Zinc Finger Protein 83 (HPF1) 2
  • HPF1 3

External Ids for ZNF83 Gene

Previous HGNC Symbols for ZNF83 Gene

  • ZNF816B

Previous GeneCards Identifiers for ZNF83 Gene

  • GC19M053746
  • GC19M053476
  • GC19M057773
  • GC19M057807
  • GC19M057189
  • GC19M053115
  • GC19M049446

Summaries for ZNF83 Gene

GeneCards Summary for ZNF83 Gene

ZNF83 (Zinc Finger Protein 83) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot for ZNF83 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF83 Gene

Additional gene information for ZNF83 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF83 Gene

Genomics for ZNF83 Gene

GeneHancer (GH) Regulatory Elements for ZNF83 Gene

Promoters and enhancers for ZNF83 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052733 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 660.3 -44.7 -44662 2.9 HDGF SMAD1 ARID4B SIN3A ZNF48 YY1 ETS1 POLR2B E2F8 ARID2 ZNF611 ZNF83 ZNF701 ZNF137P ENSG00000268970 ENSG00000269001 ZNF845 ZNF808 ZNF160 ZNF525
GH19J052687 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 657.5 +0.7 689 4.3 HDGF PKNOX1 ATF1 SMAD1 ARNT ZNF48 POLR2B ZNF766 GLIS2 E2F8 ZNF83 ZNF766 ZNF808 ZNF28 ZNF525 ENSG00000269825 ZNF701 ZNF845 ZNF160 ZNF350
GH19J052630 Promoter 0.5 EPDnew 666.9 +59.8 59808 0.1 ZNF83 ENSG00000269825 ENSG00000268970
GH19J053517 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 28 -829.0 -829033 4.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 KLF13 ZNF331 ZNF137P LENG8 ZNF525 LENG8-AS1 ZNF808 PRPF31 CNOT3 ZNF160 ZNF701
GH19J052637 Promoter/Enhancer 1.4 Ensembl ENCODE 36.4 +52.4 52360 2.2 HDGF SMAD1 ARID4B SIN3A POLR2B E2F8 ATF7 SP3 NCOA1 ZNF518A ZNF83 ZNF701 ZNF600 ZNF845 ZNF28 ZNF808 ENSG00000269001 ZNF350 ZNF160 ENSG00000268970
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF83 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF83 gene promoter:
  • Ik-1
  • AREB6
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for ZNF83 Gene

Genomic Locations for ZNF83 Gene
chr19:52,594,060-52,690,581
(GRCh38/hg38)
Size:
96,522 bases
Orientation:
Minus strand
chr19:53,097,313-53,193,886
(GRCh37/hg19)
Size:
96,574 bases
Orientation:
Minus strand

Genomic View for ZNF83 Gene

Genes around ZNF83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF83 Gene

Proteins for ZNF83 Gene

  • Protein details for ZNF83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51522-ZNF83_HUMAN
    Recommended name:
    Zinc finger protein 83
    Protein Accession:
    P51522
    Secondary Accessions:
    • A8MT75
    • Q3ZCX0
    • Q6PI08

    Protein attributes for ZNF83 Gene

    Size:
    516 amino acids
    Molecular mass:
    59710 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF83 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF83 Gene

Post-translational modifications for ZNF83 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF83 Gene

Domains & Families for ZNF83 Gene

Gene Families for ZNF83 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF83 Gene

Suggested Antigen Peptide Sequences for ZNF83 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51522

UniProtKB/Swiss-Prot:

ZNF83_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF83: view

Function for ZNF83 Gene

Molecular function for ZNF83 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 83 (C2H2 type)

Phenotypes From GWAS Catalog for ZNF83 Gene

Gene Ontology (GO) - Molecular Function for ZNF83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 16237761
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF83: view
genes like me logo Genes that share phenotypes with ZNF83: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF83

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF83 Gene

Localization for ZNF83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF83 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF83 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF83: view

Pathways & Interactions for ZNF83 Gene

SuperPathways for ZNF83 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF83: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF83 Gene

Drugs & Compounds for ZNF83 Gene

No Compound Related Data Available

Transcripts for ZNF83 Gene

Unigene Clusters for ZNF83 Gene

Zinc finger protein 83:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF83

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF83 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2:
SP3: - - - -
SP4: - - -

Relevant External Links for ZNF83 Gene

GeneLoc Exon Structure for
ZNF83
ECgene alternative splicing isoforms for
ZNF83

Expression for ZNF83 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF83 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF83 Gene:

ZNF83

SOURCE GeneReport for Unigene cluster for ZNF83 Gene:

Hs.467210

Evidence on tissue expression from TISSUES for ZNF83 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF83: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF83 Gene

Orthologs for ZNF83 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF83 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF83 34
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 41 (a)
ManyToMany
Species where no ortholog for ZNF83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF83 Gene

ENSEMBL:
Gene Tree for ZNF83 (if available)
TreeFam:
Gene Tree for ZNF83 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF83: view image

Paralogs for ZNF83 Gene

(648) SIMAP similar genes for ZNF83 Gene using alignment to 11 proteins:

  • ZNF83_HUMAN
  • H9XFB5_HUMAN
  • L0R8M2_HUMAN
  • M0QXM0_HUMAN
  • M0R099_HUMAN
  • M0R0P3_HUMAN
  • M0R183_HUMAN
  • M0R1T0_HUMAN
  • M0R287_HUMAN
  • M0R3A5_HUMAN
  • Q6P579_HUMAN

Pseudogenes.org Pseudogenes for ZNF83 Gene

genes like me logo Genes that share paralogs with ZNF83: view

Variants for ZNF83 Gene

Sequence variations from dbSNP and Humsavar for ZNF83 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs575275768 not-provided, not provided 52,613,741(-) T/G coding_sequence_variant, missense_variant
rs1000090982 -- 52,678,336(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000098586 -- 52,636,631(-) C/G intron_variant
rs1000100306 -- 52,676,667(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000186576 -- 52,660,804(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF83 Gene

Variant ID Type Subtype PubMed ID
esv2094808 CNV deletion 18987734
esv2677925 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718792 CNV deletion 23290073
esv2718793 CNV deletion 23290073
esv2718794 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv3583509 CNV loss 25503493
esv3644699 CNV loss 21293372
esv3644704 CNV loss 21293372
esv3644705 CNV gain 21293372
esv3644706 CNV loss 21293372
esv3644707 CNV gain 21293372
esv3644708 CNV loss 21293372
esv3644709 CNV gain 21293372
esv3644710 CNV loss 21293372
esv3644712 CNV gain 21293372
esv3893231 CNV loss 25118596
esv3893233 CNV loss 25118596
esv3893234 CNV gain 25118596
nsv1065584 CNV loss 25217958
nsv1066762 CNV gain 25217958
nsv1066876 CNV gain 25217958
nsv1072896 CNV deletion 25765185
nsv1078889 OTHER inversion 25765185
nsv1109211 CNV deletion 24896259
nsv1140479 CNV deletion 24896259
nsv1143408 CNV deletion 24896259
nsv1146332 OTHER inversion 26484159
nsv1153811 CNV deletion 26484159
nsv458744 CNV gain 19166990
nsv509752 CNV insertion 20534489
nsv519070 CNV loss 19592680
nsv522273 CNV loss 19592680
nsv527815 CNV loss 19592680
nsv580028 CNV gain 21841781
nsv580029 CNV loss 21841781
nsv817857 CNV gain 17921354
nsv828616 CNV gain 20364138
nsv833874 CNV loss 17160897
nsv961237 CNV duplication 23825009
nsv961238 CNV duplication 23825009

Variation tolerance for ZNF83 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.51; 91.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF83

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF83 Gene

Disorders for ZNF83 Gene

Additional Disease Information for ZNF83

No disorders were found for ZNF83 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF83 Gene

Publications for ZNF83 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4. (PMID: 8088807) Marine JC … Szpirer C (Genomics 1994) 2 3 58
  3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. (PMID: 2505992) Bellefroid EJ … Martial JA (DNA (Mary Ann Liebert, Inc.) 1989) 3 4 58
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF83 Gene

Sources for ZNF83 Gene

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