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Aliases for DOK4 Gene

Aliases for DOK4 Gene

  • Docking Protein 4 2 3 3 5
  • Downstream Of Tyrosine Kinase 4 3 4
  • Insulin Receptor Substrate 5 3 4
  • IRS-5 3 4
  • IRS5 3 4

External Ids for DOK4 Gene

Previous GeneCards Identifiers for DOK4 Gene

  • GC16M047901
  • GC16M057565
  • GC16M057240
  • GC16M057281
  • GC16M056063
  • GC16M043373

Summaries for DOK4 Gene

GeneCards Summary for DOK4 Gene

DOK4 (Docking Protein 4) is a Protein Coding gene. Among its related pathways are RET signaling and Developmental Biology. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot for DOK4 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

Gene Wiki entry for DOK4 Gene

Additional gene information for DOK4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK4 Gene

Genomics for DOK4 Gene

GeneHancer (GH) Regulatory Elements for DOK4 Gene

Promoters and enhancers for DOK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J057482 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 663.4 +2.5 2506 5.3 HDGF FOXA2 MLX ARID4B SIN3A SLC30A9 ZNF213 ZNF143 ZNF263 SP5 DOK4 POLR2C CIAPIN1 COQ9 LOC105371286 RSPRY1 CX3CL1 CCL22 USB1 PIR51542
GH16J057477 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 660.7 +7.6 7554 4.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 GLIS2 DOK4 COQ9 CIAPIN1 CCDC102A PIR51542
GH16J057531 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.9 -48.5 -48487 8.1 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A IRF4 ZNF207 ZNF143 FOS CCDC102A PIR39147 DOK4 ADGRG5
GH16J057462 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.6 +24.4 24434 1.8 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 POLR2C ENSG00000260345 RSPRY1 CIAPIN1 LOC101927556 CSNK2A2 NUP93 DOK4 CCDC102A PIR63065
GH16J057506 Enhancer 0.8 FANTOM5 ENCODE 19.3 -21.6 -21641 4.3 GLIS1 ZFP36 RCOR1 NR2F6 ZIC2 CHD2 SP7 NR2F2 DOK4 POLR2C COQ9 CIAPIN1 ADGRG1 CCDC102A PIR46688 ADGRG5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DOK4 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • Elk-1
  • AREB6
  • HNF-4alpha2
  • COUP
  • COUP-TF
  • COUP-TF1

Genomic Locations for DOK4 Gene

Genomic Locations for DOK4 Gene
chr16:57,471,922-57,487,327
(GRCh38/hg38)
Size:
15,406 bases
Orientation:
Minus strand
chr16:57,505,863-57,521,239
(GRCh37/hg19)
Size:
15,377 bases
Orientation:
Minus strand

Genomic View for DOK4 Gene

Genes around DOK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK4 Gene

Proteins for DOK4 Gene

  • Protein details for DOK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEW6-DOK4_HUMAN
    Recommended name:
    Docking protein 4
    Protein Accession:
    Q8TEW6
    Secondary Accessions:
    • O75209
    • Q9BTP2
    • Q9NVV3

    Protein attributes for DOK4 Gene

    Size:
    326 amino acids
    Molecular mass:
    37028 Da
    Quaternary structure:
    • Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET Tyr-1062 (By similarity).
    SequenceCaution:
    • Sequence=AAC24310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DOK4 Gene

Post-translational modifications for DOK4 Gene

  • Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOK4 Gene

Domains & Families for DOK4 Gene

Gene Families for DOK4 Gene

Protein Domains for DOK4 Gene

Suggested Antigen Peptide Sequences for DOK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEW6

UniProtKB/Swiss-Prot:

DOK4_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type B subfamily.
Domain:
  • PTB domain mediates receptor interaction.
Family:
  • Belongs to the DOK family. Type B subfamily.
genes like me logo Genes that share domains with DOK4: view

Function for DOK4 Gene

Molecular function for DOK4 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

Phenotypes From GWAS Catalog for DOK4 Gene

Gene Ontology (GO) - Molecular Function for DOK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 obsolete signal transducer activity, downstream of receptor IEA --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with DOK4: view
genes like me logo Genes that share phenotypes with DOK4: view

Animal Model Products

miRNA for DOK4 Gene

miRTarBase miRNAs that target DOK4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOK4 Gene

Localization for DOK4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOK4 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DOK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOK4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOK4 Gene

Pathways & Interactions for DOK4 Gene

genes like me logo Genes that share pathways with DOK4: view

Pathways by source for DOK4 Gene

1 BioSystems pathway for DOK4 Gene
3 Reactome pathways for DOK4 Gene
1 Qiagen pathway for DOK4 Gene

SIGNOR curated interactions for DOK4 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for DOK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007399 nervous system development IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with DOK4: view

Drugs & Compounds for DOK4 Gene

(1) Drugs for DOK4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DOK4: view

Transcripts for DOK4 Gene

Unigene Clusters for DOK4 Gene

Docking protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOK4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e ^ 12a ·
SP1: - -
SP2: -
SP3:
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - - - - -
SP16:
SP17: - - - - -
SP18: - - - - - - -

ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DOK4 Gene

GeneLoc Exon Structure for
DOK4
ECgene alternative splicing isoforms for
DOK4

Expression for DOK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOK4 Gene

This gene is overexpressed in Bone marrow stromal cell (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DOK4 Gene



Protein tissue co-expression partners for DOK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DOK4 Gene:

DOK4

SOURCE GeneReport for Unigene cluster for DOK4 Gene:

Hs.279832

mRNA Expression by UniProt/SwissProt for DOK4 Gene:

Q8TEW6-DOK4_HUMAN
Tissue specificity: Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.

Evidence on tissue expression from TISSUES for DOK4 Gene

  • Nervous system(4.6)
  • Intestine(4.4)
  • Muscle(4.2)
  • Pancreas(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with DOK4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOK4 Gene

Orthologs for DOK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK4 34 33
  • 99.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DOK4 34
  • 98 (a)
OneToOne
LOC618756 33
  • 93.56 (n)
oppossum
(Monodelphis domestica)
Mammalia DOK4 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOK4 34 33
  • 92.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dok4 33
  • 91.9 (n)
mouse
(Mus musculus)
Mammalia Dok4 16 34 33
  • 91.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DOK4 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK4 34 33
  • 83.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOK4 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dok4 33
  • 71.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia dok4-prov 33
zebrafish
(Danio rerio)
Actinopterygii CR376738.1 34
  • 74 (a)
OneToOne
LOC568912 33
  • 72.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dok 34
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 34
  • 15 (a)
OneToMany
Species where no ortholog for DOK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK4 Gene

ENSEMBL:
Gene Tree for DOK4 (if available)
TreeFam:
Gene Tree for DOK4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DOK4: view image

Paralogs for DOK4 Gene

Paralogs for DOK4 Gene

(3) SIMAP similar genes for DOK4 Gene using alignment to 12 proteins:

  • DOK4_HUMAN
  • H3BN90_HUMAN
  • H3BPY9_HUMAN
  • H3BQ19_HUMAN
  • H3BS85_HUMAN
  • H3BSK0_HUMAN
  • H3BST9_HUMAN
  • H3BTI4_HUMAN
  • H3BTI7_HUMAN
  • H3BTK2_HUMAN
  • H3BV67_HUMAN
  • H3BVB4_HUMAN
genes like me logo Genes that share paralogs with DOK4: view

Variants for DOK4 Gene

Sequence variations from dbSNP and Humsavar for DOK4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000010483 -- 57,475,658(-) G/A/C intron_variant
rs1000699086 -- 57,485,290(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000751131 -- 57,485,724(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000809451 -- 57,486,091(-) G/T genic_upstream_transcript_variant, intron_variant
rs1001312316 -- 57,480,140(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DOK4 Gene

Variant ID Type Subtype PubMed ID
nsv833245 CNV loss 17160897

Variation tolerance for DOK4 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOK4 Gene

Human Gene Mutation Database (HGMD)
DOK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK4 Gene

Disorders for DOK4 Gene

Additional Disease Information for DOK4

No disorders were found for DOK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK4 Gene

Publications for DOK4 Gene

  1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C … Nunès JA (Genes and immunity 2003) 3 4 22 58
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. (PMID: 12730241) Cai D … Shoelson SE (The Journal of biological chemistry 2003) 3 4 58

Products for DOK4 Gene

Sources for DOK4 Gene

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