Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PKIB Gene

Aliases for PKIB Gene

  • CAMP-Dependent Protein Kinase Inhibitor Beta 2 3 3 5
  • Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Beta 2 3
  • PKI-Beta 3 4
  • PRKACN2 3 4
  • CAMP-Dependent Protein Kinase Inhibitor 2 3

External Ids for PKIB Gene

Previous HGNC Symbols for PKIB Gene

  • PRKACN2

Previous GeneCards Identifiers for PKIB Gene

  • GC06P122701
  • GC06P122773
  • GC06P122834
  • GC06P120370

Summaries for PKIB Gene

Entrez Gene Summary for PKIB Gene

  • This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PKIB Gene

PKIB (CAMP-Dependent Protein Kinase Inhibitor Beta) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include cAMP-dependent protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for PKIB Gene

  • Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Wiki entry for PKIB Gene

Additional gene information for PKIB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKIB Gene

Genomics for PKIB Gene

GeneHancer (GH) Regulatory Elements for PKIB Gene

Promoters and enhancers for PKIB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J122470 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 655.8 -0.5 -535 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B PKIB ENSG00000279114 SERINC1 HSF2 ENSG00000275339
GH06J122609 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.1 +138.8 138773 2.6 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 GLIS2 ZNF213 NFKBIZ SP3 PKIB SERINC1 HSF2 SMPDL3A PIR47029 ENSG00000272472
GH06J122717 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 656.6 +245.8 245753 0.7 PKIB SMPDL3A RN7SL564P ENSG00000272472
GH06J122398 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.1 -72.1 -72122 2.4 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 FOS HSF2 PKIB ENSG00000279453
GH06J122712 Enhancer 1 Ensembl ENCODE 8.7 +238.4 238384 0.2 ATF1 PKNOX1 BMI1 YY1 ZNF766 ATF7 ETV6 IKZF2 RUNX3 CREM SMPDL3A PKIB TRDN RN7SL564P ENSG00000272472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PKIB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PKIB gene promoter:
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • Max
  • c-Myc
  • CUTL1
  • AML1a
  • Oct-B1
  • oct-B2

Genomic Locations for PKIB Gene

Genomic Locations for PKIB Gene
chr6:122,471,917-122,726,373
(GRCh38/hg38)
Size:
254,457 bases
Orientation:
Plus strand
chr6:122,793,062-123,047,518
(GRCh37/hg19)
Size:
254,457 bases
Orientation:
Plus strand

Genomic View for PKIB Gene

Genes around PKIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKIB Gene

Proteins for PKIB Gene

  • Protein details for PKIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C010-IPKB_HUMAN
    Recommended name:
    cAMP-dependent protein kinase inhibitor beta
    Protein Accession:
    Q9C010
    Secondary Accessions:
    • B2RCK2
    • Q567T9
    • Q5T0Z7

    Protein attributes for PKIB Gene

    Size:
    78 amino acids
    Molecular mass:
    8468 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PKIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKIB Gene

Post-translational modifications for PKIB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PKIB Gene

Domains & Families for PKIB Gene

Gene Families for PKIB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PKIB Gene

Graphical View of Domain Structure for InterPro Entry

Q9C010

UniProtKB/Swiss-Prot:

IPKB_HUMAN :
  • Belongs to the PKI family.
Family:
  • Belongs to the PKI family.
genes like me logo Genes that share domains with PKIB: view

Function for PKIB Gene

Molecular function for PKIB Gene

UniProtKB/Swiss-Prot Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Phenotypes From GWAS Catalog for PKIB Gene

Gene Ontology (GO) - Molecular Function for PKIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004862 cAMP-dependent protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with PKIB: view
genes like me logo Genes that share phenotypes with PKIB: view

Animal Models for PKIB Gene

MGI Knock Outs for PKIB:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKIB Gene

Localization for PKIB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKIB gene
Compartment Confidence
nucleus 4
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PKIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PKIB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PKIB Gene

Pathways & Interactions for PKIB Gene

genes like me logo Genes that share pathways with PKIB: view

Pathways by source for PKIB Gene

1 GeneGo (Thomson Reuters) pathway for PKIB Gene
1 Qiagen pathway for PKIB Gene

Gene Ontology (GO) - Biological Process for PKIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 21531765
GO:0051973 positive regulation of telomerase activity IMP 21531765
GO:0071901 negative regulation of protein serine/threonine kinase activity IEA --
GO:1904355 positive regulation of telomere capping IMP 21531765
genes like me logo Genes that share ontologies with PKIB: view

No data available for SIGNOR curated interactions for PKIB Gene

Drugs & Compounds for PKIB Gene

(1) Drugs for PKIB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with PKIB: view

Transcripts for PKIB Gene

Unigene Clusters for PKIB Gene

Protein kinase (cAMP-dependent, catalytic) inhibitor beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKIB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for PKIB Gene

GeneLoc Exon Structure for
PKIB
ECgene alternative splicing isoforms for
PKIB

Expression for PKIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PKIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKIB Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x17.9), Brain - Cerebellum (x12.6), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for PKIB Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PKIB Gene



Protein tissue co-expression partners for PKIB Gene

NURSA nuclear receptor signaling pathways regulating expression of PKIB Gene:

PKIB

SOURCE GeneReport for Unigene cluster for PKIB Gene:

Hs.744965

Evidence on tissue expression from TISSUES for PKIB Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PKIB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKIB Gene

Orthologs for PKIB Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKIB 34 33
  • 99.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PKIB 34 33
  • 82.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PKIB 34 33
  • 80.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pkib 16 34 33
  • 76.59 (n)
rat
(Rattus norvegicus)
Mammalia Pkib 33
  • 74.21 (n)
chicken
(Gallus gallus)
Aves PKIB 34
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pkib 34
  • 42 (a)
OneToOne
Species where no ortholog for PKIB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PKIB Gene

ENSEMBL:
Gene Tree for PKIB (if available)
TreeFam:
Gene Tree for PKIB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PKIB: view image

Paralogs for PKIB Gene

(1) SIMAP similar genes for PKIB Gene using alignment to 2 proteins:

  • IPKB_HUMAN
  • Q5T0Z6_HUMAN
genes like me logo Genes that share paralogs with PKIB: view

No data available for Paralogs for PKIB Gene

Variants for PKIB Gene

Sequence variations from dbSNP and Humsavar for PKIB Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000000071 -- 122,545,977(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000012417 -- 122,542,469(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000042949 -- 122,508,310(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000051231 -- 122,680,811(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000062978 -- 122,590,770(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PKIB Gene

Variant ID Type Subtype PubMed ID
esv2557344 CNV insertion 19546169
esv2759467 CNV loss 17122850
esv3305666 CNV mobile element insertion 20981092
esv3309506 CNV mobile element insertion 20981092
esv3437628 CNV insertion 20981092
esv3440768 CNV insertion 20981092
esv3571381 CNV loss 25503493
esv3610612 CNV loss 21293372
esv3610615 CNV loss 21293372
esv8540 CNV gain 19470904
nsv1018215 CNV loss 25217958
nsv1027182 CNV gain 25217958
nsv1161448 CNV duplication 26073780
nsv830791 CNV gain 17160897
nsv965761 CNV duplication 23825009

Variation tolerance for PKIB Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PKIB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKIB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKIB Gene

Disorders for PKIB Gene

Additional Disease Information for PKIB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PKIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKIB Gene

Publications for PKIB Gene

  1. Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA. (PMID: 10880337) Zheng L … Zhao S (The Biochemical journal 2000) 2 3 4 22 58
  2. Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways. (PMID: 19483721) Chung S … Nakagawa H (Oncogene 2009) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. PKIB promotes cell proliferation and the invasion-metastasis cascade through the PI3K/Akt pathway in NSCLC cells. (PMID: 27325557) Dou P … Zhang L (Experimental biology and medicine (Maywood, N.J.) 2016) 3 58

Products for PKIB Gene

Sources for PKIB Gene

Content
Loading form....