Aliases for PKIA Gene
External Ids for PKIA Gene
Previous HGNC Symbols for PKIA Gene
Previous GeneCards Identifiers for PKIA Gene
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PKIA Gene
PKIA (CAMP-Dependent Protein Kinase Inhibitor Alpha) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include protein kinase A catalytic subunit binding and cAMP-dependent protein kinase inhibitor activity.
UniProtKB/Swiss-Prot for PKIA Gene
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.