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Aliases for PNRC2 Gene

Aliases for PNRC2 Gene

  • Proline Rich Nuclear Receptor Coactivator 2 2 3 5
  • Proline-Rich Nuclear Receptor Coactivator 2 2

External Ids for PNRC2 Gene

Previous GeneCards Identifiers for PNRC2 Gene

  • GC01P023346
  • GC01M117667
  • GC01P9A0092
  • GC01P9A4031
  • GC01P024031
  • GC01P024158
  • GC01P024285

Summaries for PNRC2 Gene

GeneCards Summary for PNRC2 Gene

PNRC2 (Proline Rich Nuclear Receptor Coactivator 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. An important paralog of this gene is PNRC1.

UniProtKB/Swiss-Prot for PNRC2 Gene

  • Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5 UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).

Gene Wiki entry for PNRC2 Gene

Additional gene information for PNRC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNRC2 Gene

Genomics for PNRC2 Gene

GeneHancer (GH) Regulatory Elements for PNRC2 Gene

Promoters and enhancers for PNRC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023954 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.0 -967 7.5 MLX DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A ZNF610 PNRC2 SRSF10 ELOA KDM1A SRRM1 LINC01355 ZNF436 ENSG00000230228
GH01I023691 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 41.6 -266.5 -266486 3.1 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 RPL11 SRSF10 SRRM1 LINC01355 PNRC2 HNRNPR KDM1A ELOA ASAP3 GC01M023708
GH01I023166 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.3 -790.8 -790771 4.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 YY1 POLR2B ZNF213 ZNF548 LUZP1 GC01P023167 SRSF10 ZBTB40 PNRC2 RPL11 LINC01355 HNRNPR ELOA LACTBL1
GH01I023626 Enhancer 1.2 Ensembl ENCODE dbSUPER 33.3 -331.9 -331875 1.7 HDAC1 YBX3 PKNOX1 ATF1 ZNF133 MZF1 NFXL1 ZNF366 RUNX3 SMARCA5 SRSF10 RPL11 PNRC2 ELOA LINC01355 FUCA1 HNRNPR ID3 MDS2 E2F2
GH01I023975 Promoter/Enhancer 2.9 UCNEbase EPDnew Ensembl ENCODE dbSUPER 12 +19.7 19728 6.4 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SRSF10 ELOA SRRM1 LINC01355 KDM1A RPL11 ZNF436-AS1 PNRC2 CNR2 RUNX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PNRC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PNRC2 gene promoter:

Genomic Locations for PNRC2 Gene

Genomic Locations for PNRC2 Gene
chr1:23,959,109-23,963,462
(GRCh38/hg38)
Size:
4,354 bases
Orientation:
Plus strand
chr1:24,285,599-24,289,952
(GRCh37/hg19)

Genomic View for PNRC2 Gene

Genes around PNRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNRC2 Gene

Proteins for PNRC2 Gene

  • Protein details for PNRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPJ4-PNRC2_HUMAN
    Recommended name:
    Proline-rich nuclear receptor coactivator 2
    Protein Accession:
    Q9NPJ4
    Secondary Accessions:
    • B4DU72

    Protein attributes for PNRC2 Gene

    Size:
    139 amino acids
    Molecular mass:
    15591 Da
    Quaternary structure:
    • Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form (PubMed:19150429, PubMed:25775514). Interacts with DCP1A (PubMed:19150429, PubMed:25775514). Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR (PubMed:11574675, PubMed:14651967, PubMed:25775514).

    Three dimensional structures from OCA and Proteopedia for PNRC2 Gene

    Alternative splice isoforms for PNRC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNRC2 Gene

Post-translational modifications for PNRC2 Gene

  • Ubiquitination at isoforms=286
  • Modification sites at PhosphoSitePlus

Other Protein References for PNRC2 Gene

No data available for DME Specific Peptides for PNRC2 Gene

Domains & Families for PNRC2 Gene

Gene Families for PNRC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PNRC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNRC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPJ4

UniProtKB/Swiss-Prot:

PNRC2_HUMAN :
  • The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif.
  • Belongs to the PNRC family. PNRC2 subfamily.
Domain:
  • The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif.
Family:
  • Belongs to the PNRC family. PNRC2 subfamily.
genes like me logo Genes that share domains with PNRC2: view

Function for PNRC2 Gene

Molecular function for PNRC2 Gene

UniProtKB/Swiss-Prot Function:
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5 UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).

Phenotypes From GWAS Catalog for PNRC2 Gene

Gene Ontology (GO) - Molecular Function for PNRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19150429
genes like me logo Genes that share ontologies with PNRC2: view
genes like me logo Genes that share phenotypes with PNRC2: view

Animal Models for PNRC2 Gene

MGI Knock Outs for PNRC2:

miRNA for PNRC2 Gene

miRTarBase miRNAs that target PNRC2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNRC2 Gene

Localization for PNRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNRC2 Gene

Nucleus. Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNRC2 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PNRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA,IDA 19150429
GO:0005634 nucleus IDA,IEA 19150429
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with PNRC2: view

Pathways & Interactions for PNRC2 Gene

genes like me logo Genes that share pathways with PNRC2: view

Gene Ontology (GO) - Biological Process for PNRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA TAS 19150429
genes like me logo Genes that share ontologies with PNRC2: view

No data available for SIGNOR curated interactions for PNRC2 Gene

Drugs & Compounds for PNRC2 Gene

No Compound Related Data Available

Transcripts for PNRC2 Gene

Unigene Clusters for PNRC2 Gene

Proline-rich nuclear receptor coactivator 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNRC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for PNRC2 Gene

GeneLoc Exon Structure for
PNRC2
ECgene alternative splicing isoforms for
PNRC2

Expression for PNRC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PNRC2 Gene:

PNRC2

SOURCE GeneReport for Unigene cluster for PNRC2 Gene:

Hs.7862

mRNA Expression by UniProt/SwissProt for PNRC2 Gene:

Q9NPJ4-PNRC2_HUMAN
Tissue specificity: Expressed in heart, lung, muscle and brain.

Evidence on tissue expression from TISSUES for PNRC2 Gene

  • Lung(4.4)
  • Blood(4)
  • Nervous system(2.8)
  • Heart(2.7)
  • Intestine(2.6)
  • Kidney(2.6)
  • Stomach(2.6)
  • Liver(2.4)
  • Muscle(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PNRC2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNRC2 Gene

Orthologs for PNRC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PNRC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNRC2 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PNRC2 33 34
  • 93.29 (n)
rat
(Rattus norvegicus)
Mammalia Pnrc2 33
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Pnrc2 33 16 34
  • 86.33 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves PNRC2 33 34
  • 79.38 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pnrc2 33
  • 65.43 (n)
Str.8015 33
zebrafish
(Danio rerio)
Actinopterygii pnrc2 33 34
  • 58.59 (n)
Species where no ortholog for PNRC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNRC2 Gene

ENSEMBL:
Gene Tree for PNRC2 (if available)
TreeFam:
Gene Tree for PNRC2 (if available)

Paralogs for PNRC2 Gene

Paralogs for PNRC2 Gene

(2) SIMAP similar genes for PNRC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNRC2: view

Variants for PNRC2 Gene

Sequence variations from dbSNP and Humsavar for PNRC2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000069111 -- 23,959,732(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000070763 -- 23,959,619(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001070607 -- 23,960,730(+) G/A intron_variant
rs1001080465 -- 23,960,570(+) C/T intron_variant
rs1001732850 -- 23,958,692(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PNRC2 Gene

Variant ID Type Subtype PubMed ID
dgv60n106 CNV deletion 24896259
esv2662136 CNV deletion 23128226
esv2676255 CNV deletion 23128226
nsv1075339 CNV deletion 25765185
nsv6742 CNV insertion 18451855
nsv950285 CNV duplication 24416366

Variation tolerance for PNRC2 Gene

Gene Damage Index Score: 0.12; 2.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNRC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNRC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNRC2 Gene

Disorders for PNRC2 Gene

Additional Disease Information for PNRC2

No disorders were found for PNRC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNRC2 Gene

Publications for PNRC2 Gene

  1. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PMID: 14651967) Hentschke M … Borgmeyer U (Biochemical and biophysical research communications 2003) 3 4 22 58
  2. PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. (PMID: 11574675) Zhou D … Chen S (Nucleic acids research 2001) 2 3 4 58
  3. Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation. (PMID: 25775514) Cho H … Kim YK (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 58
  4. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PMID: 19150429) Cho H … Kim YK (Molecular cell 2009) 3 4 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for PNRC2 Gene

Sources for PNRC2 Gene

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