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Aliases for AP1AR Gene

Aliases for AP1AR Gene

  • Adaptor Related Protein Complex 1 Associated Regulatory Protein 2 3 5
  • Gamma-1-Adaptin Brefeldin A Resistance Protein 3 4
  • Gamma-A1-Adaptin And Kinesin Interactor 3 4
  • Gamma-BAR 3 4
  • C4orf16 3 4
  • Gadkin 3 4
  • GBAR 3 4
  • Adapter-Related Protein Complex 1-Associated Regulatory Protein 3
  • Adaptor-Related Protein Complex 1-Associated Regulatory Protein 4
  • Adaptor-Related Protein Complex 1 Associated Regulatory Protein 2
  • Gamma1-Adaptin Brefeldin A Resistance Protein, Gamma-BAR 3
  • AP-1 Complex-Associated Regulatory Protein 3
  • Gamma1-Adaptin Brefeldin A Resistance 2
  • Chromosome 4 Open Reading Frame 16 2
  • PRO0971 3
  • 2C18 3
  • 2c18 4

External Ids for AP1AR Gene

Previous HGNC Symbols for AP1AR Gene

  • C4orf16

Previous GeneCards Identifiers for AP1AR Gene

  • GC04P113373
  • GC04P113153
  • GC04P108884

Summaries for AP1AR Gene

GeneCards Summary for AP1AR Gene

AP1AR (Adaptor Related Protein Complex 1 Associated Regulatory Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinesin binding and AP-1 adaptor complex binding.

UniProtKB/Swiss-Prot for AP1AR Gene

  • Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Gene Wiki entry for AP1AR Gene

Additional gene information for AP1AR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1AR Gene

Genomics for AP1AR Gene

GeneHancer (GH) Regulatory Elements for AP1AR Gene

Promoters and enhancers for AP1AR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J112230 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.3 299 3.7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 AP1AR ENSG00000260526 ZGRF1 TIFA ENSG00000249532 LARP7 ENSG00000272567
GH04J112282 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14 +54.6 54616 7.6 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B TIFA ALPK1 FAM241A AP1AR ENSG00000249532 ENSG00000250966 RTEL1P1 LARP7 ZGRF1 GC04P112321
GH04J112311 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +81.1 81119 1.9 HDGF PKNOX1 BATF IRF4 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 TIFA AP1AR ALPK1 LARP7 GC04P112321
GH04J112144 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 3.2 -85.3 -85264 3.3 HDGF ATF1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF766 CBX5 ATF7 FAM241A ZGRF1 TIFA LARP7 AP1AR RPL36AP19
GH04J111990 Enhancer 1.2 FANTOM5 Ensembl ENCODE 2.6 -240.0 -239983 1.5 SMAD1 JUN BACH1 EBF1 BMI1 FEZF1 IRF4 ZBTB40 FOSL1 ZNF335 FAM241A AP1AR TIFA PIR60785 ENSG00000249815 LOC105377369
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AP1AR on UCSC Golden Path with GeneCards custom track

Genomic Locations for AP1AR Gene

Genomic Locations for AP1AR Gene
chr4:112,231,737-112,272,715
(GRCh38/hg38)
Size:
40,979 bases
Orientation:
Plus strand
chr4:113,152,893-113,191,211
(GRCh37/hg19)
Size:
38,319 bases
Orientation:
Plus strand

Genomic View for AP1AR Gene

Genes around AP1AR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1AR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1AR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1AR Gene

Proteins for AP1AR Gene

  • Protein details for AP1AR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HQ0-AP1AR_HUMAN
    Recommended name:
    AP-1 complex-associated regulatory protein
    Protein Accession:
    Q63HQ0
    Secondary Accessions:
    • B2RCV7
    • Q96GG6
    • Q9H0V0
    • Q9P1L4

    Protein attributes for AP1AR Gene

    Size:
    302 amino acids
    Molecular mass:
    34280 Da
    Quaternary structure:
    • Interacts (via coiled-coil domain) with AP1G1 (via GAE domain). Interacts with KIF5B. Associates with the Arp2/3 complex.
    SequenceCaution:
    • Sequence=AAF71037.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AP1AR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1AR Gene

Post-translational modifications for AP1AR Gene

Other Protein References for AP1AR Gene

Antibody Products

  • Boster Bio Antibodies for AP1AR
  • Santa Cruz Biotechnology (SCBT) Antibodies for AP1AR

No data available for DME Specific Peptides for AP1AR Gene

Domains & Families for AP1AR Gene

Gene Families for AP1AR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AP1AR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AP1AR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AP1AR: view

No data available for UniProtKB/Swiss-Prot for AP1AR Gene

Function for AP1AR Gene

Molecular function for AP1AR Gene

UniProtKB/Swiss-Prot Function:
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Gene Ontology (GO) - Molecular Function for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019894 kinesin binding IDA 19706427
GO:0035650 AP-1 adaptor complex binding IDA,IEA 19706427
genes like me logo Genes that share ontologies with AP1AR: view
genes like me logo Genes that share phenotypes with AP1AR: view

Animal Models for AP1AR Gene

MGI Knock Outs for AP1AR:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AP1AR Gene

Localization for AP1AR Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1AR Gene

Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP1AR gene
Compartment Confidence
golgi apparatus 5
endosome 5
cytosol 3
mitochondrion 2
peroxisome 2
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AP1AR: view

Pathways & Interactions for AP1AR Gene

SuperPathways for AP1AR Gene

No Data Available

Gene Ontology (GO) - Biological Process for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001920 negative regulation of receptor recycling IMP 19706427
GO:0015031 protein transport IEA --
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IEA --
GO:0034613 cellular protein localization IEA --
GO:0048203 vesicle targeting, trans-Golgi to endosome IEA,IDA 19706427
genes like me logo Genes that share ontologies with AP1AR: view

No data available for Pathways by source and SIGNOR curated interactions for AP1AR Gene

Drugs & Compounds for AP1AR Gene

No Compound Related Data Available

Transcripts for AP1AR Gene

Unigene Clusters for AP1AR Gene

Adaptor-related protein complex 1 associated regulatory protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1AR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for AP1AR Gene

GeneLoc Exon Structure for
AP1AR
ECgene alternative splicing isoforms for
AP1AR

Expression for AP1AR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AP1AR Gene

Protein differential expression in normal tissues from HIPED for AP1AR Gene

This gene is overexpressed in Testis (50.4) and Blymphocyte (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AP1AR Gene



Protein tissue co-expression partners for AP1AR Gene

NURSA nuclear receptor signaling pathways regulating expression of AP1AR Gene:

AP1AR

SOURCE GeneReport for Unigene cluster for AP1AR Gene:

Hs.435991

Evidence on tissue expression from TISSUES for AP1AR Gene

  • Nervous system(4.3)
  • Pancreas(4.1)
  • Liver(2.7)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with AP1AR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP1AR Gene

Orthologs for AP1AR Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP1AR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP1AR 34 33
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AP1AR 34 33
  • 94.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AP1AR 33
  • 94.59 (n)
MGC155012 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ap1ar 33
  • 85.89 (n)
mouse
(Mus musculus)
Mammalia Ap1ar 16 34 33
  • 84 (n)
chicken
(Gallus gallus)
Aves AP1AR 34 33
  • 81.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP1AR 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1ar 33
  • 74.73 (n)
Str.1425 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11377 33
zebrafish
(Danio rerio)
Actinopterygii LOC100332265 33
  • 61.17 (n)
CABZ01003022.1 34
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9297 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToOne
Species where no ortholog for AP1AR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP1AR Gene

ENSEMBL:
Gene Tree for AP1AR (if available)
TreeFam:
Gene Tree for AP1AR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AP1AR: view image

Paralogs for AP1AR Gene

No data available for Paralogs for AP1AR Gene

Variants for AP1AR Gene

Sequence variations from dbSNP and Humsavar for AP1AR Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000002301 -- 112,231,757(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000151706 -- 112,257,014(+) G/T intron_variant
rs1000153271 -- 112,238,689(+) A/G intron_variant
rs1000182876 -- 112,264,830(+) C/A intron_variant
rs1000194627 -- 112,245,119(+) A/G intron_variant

Variation tolerance for AP1AR Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AP1AR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AP1AR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AP1AR Gene

Disorders for AP1AR Gene

Additional Disease Information for AP1AR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AP1AR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AP1AR Gene

Publications for AP1AR Gene

  1. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PMID: 15775984) Neubrand VE … Simpson JC (The EMBO journal 2005) 2 3 4 58
  2. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. (PMID: 22689987) Maritzen T … Haucke V (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 58
  3. Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. (PMID: 21525240) Laulagnier K … Gruenberg J (Molecular biology of the cell 2011) 3 4 58
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 44 58
  5. A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR. (PMID: 19965873) Maritzen T … Haucke V (The Journal of biological chemistry 2010) 3 4 58

Products for AP1AR Gene

Sources for AP1AR Gene

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