Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF331 Gene

Aliases for ZNF331 Gene

  • Zinc Finger Protein 331 2 3 3 5
  • C2H2-Like Zinc Finger Protein Rearranged In Thyroid Adenomas 3 4
  • Zinc Finger Protein 361 3 4
  • Zinc Finger Protein 463 3 4
  • ZNF361 3 4
  • ZNF463 3 4
  • RITA 3 4
  • Rearranged In Thyroid Adenomas 2
  • KRAB Zinc Finger Protein 3

External Ids for ZNF331 Gene

Previous GeneCards Identifiers for ZNF331 Gene

  • GC19P058700
  • GC19P058716
  • GC19P054024
  • GC19P050344

Summaries for ZNF331 Gene

Entrez Gene Summary for ZNF331 Gene

  • This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZNF331 Gene

ZNF331 (Zinc Finger Protein 331) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF283.

UniProtKB/Swiss-Prot for ZNF331 Gene

  • May be involved in transcriptional regulation. May play a role in spermatogenesis.

Gene Wiki entry for ZNF331 Gene

Additional gene information for ZNF331 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF331 Gene

Genomics for ZNF331 Gene

GeneHancer (GH) Regulatory Elements for ZNF331 Gene

Promoters and enhancers for ZNF331 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053535 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 656.1 +33.4 33428 4.6 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ETS1 GLIS2 ZNF143 ZNF331 TPM3P9 ENSG00000274892 DPRX
GH19J053553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.2 +50.7 50668 2.6 HDGF PKNOX1 CLOCK ZNF133 NEUROD1 SIN3A ZNF2 ETS1 ZNF143 ATF7 ZNF331 ZNF160 ZNF845 PRPF31 ENSG00000269001 ZNF347 ZNF600 LENG8-AS1 LENG8 ZNF701
GH19J053517 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 657.9 +15.7 15734 4.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 KLF13 ZNF331 ZNF137P LENG8 ZNF525 LENG8-AS1 ZNF808 PRPF31 CNOT3 ZNF160 ZNF701
GH19J053503 Enhancer 0.8 Ensembl ENCODE 650.7 +0.7 651 1.9 SOX5 CTCF SOX13 ZNF654 SAP130 ARID4B ZNF2 RAD21 ZNF843 TGIF2 VN1R103P ZNF331 ENSG00000274892
GH19J054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +701.8 701830 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 CNOT3 LENG8-AS1 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF331 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF331 gene promoter:
  • AP-1
  • p53
  • ATF-2
  • c-Jun

Genomic Locations for ZNF331 Gene

Genomic Locations for ZNF331 Gene
76,390 bases
Plus strand
59,347 bases
Plus strand

Genomic View for ZNF331 Gene

Genes around ZNF331 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF331 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF331 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF331 Gene

Proteins for ZNF331 Gene

  • Protein details for ZNF331 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 331
    Protein Accession:
    Secondary Accessions:
    • Q96GJ4

    Protein attributes for ZNF331 Gene

    463 amino acids
    Molecular mass:
    53739 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF331 Gene

Post-translational modifications for ZNF331 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF331 Gene

Domains & Families for ZNF331 Gene

Gene Families for ZNF331 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF331 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF331: view

Function for ZNF331 Gene

Molecular function for ZNF331 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May play a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for ZNF331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10502321
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF331: view
genes like me logo Genes that share phenotypes with ZNF331: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF331

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF331 Gene

Localization for ZNF331 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF331 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF331 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF331: view

Pathways & Interactions for ZNF331 Gene

SuperPathways for ZNF331 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF331: view

Pathways by source for ZNF331 Gene

2 Reactome pathways for ZNF331 Gene

Gene Ontology (GO) - Biological Process for ZNF331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF331: view

No data available for SIGNOR curated interactions for ZNF331 Gene

Drugs & Compounds for ZNF331 Gene

(1) Drugs for ZNF331 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF331: view

Transcripts for ZNF331 Gene

Unigene Clusters for ZNF331 Gene

Zinc finger protein 331:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF331

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF331 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP8: - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - - - - - - -
SP12: -
SP14: - - - -

Relevant External Links for ZNF331 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF331 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF331 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF331 Gene

This gene is overexpressed in Artery - Tibial (x4.2) and Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF331 Gene

This gene is overexpressed in Placenta (54.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF331 Gene

Protein tissue co-expression partners for ZNF331 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF331 Gene:


SOURCE GeneReport for Unigene cluster for ZNF331 Gene:


mRNA Expression by UniProt/SwissProt for ZNF331 Gene:

Tissue specificity: Testis specific.

Evidence on tissue expression from TISSUES for ZNF331 Gene

  • Eye(4.1)
  • Nervous system(2.7)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with ZNF331: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF331 Gene

Orthologs for ZNF331 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF331 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF331 34 33
  • 99.21 (n)
(Canis familiaris)
Mammalia ZNF331 34 33
  • 85.53 (n)
(Bos Taurus)
Mammalia ZNF331 34 33
  • 81 (n)
Species where no ortholog for ZNF331 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF331 Gene

Gene Tree for ZNF331 (if available)
Gene Tree for ZNF331 (if available)
Evolutionary constrained regions (ECRs) for ZNF331: view image

Paralogs for ZNF331 Gene

(568) SIMAP similar genes for ZNF331 Gene using alignment to 16 proteins:

  • ZN331_HUMAN
  • D6RH27_HUMAN
  • E7EV14_HUMAN
  • Q6PK05_HUMAN
  • Q71QC3_HUMAN
  • Q71QC4_HUMAN
  • Q71QC5_HUMAN
  • Q71QC6_HUMAN
  • Q71QC8_HUMAN
  • Q71QC9_HUMAN Pseudogenes for ZNF331 Gene

genes like me logo Genes that share paralogs with ZNF331: view

Variants for ZNF331 Gene

Sequence variations from dbSNP and Humsavar for ZNF331 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000009240 -- 53,508,975(+) CAC/CACAC genic_upstream_transcript_variant, intron_variant
rs1000066515 -- 53,508,651(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000075940 -- 53,535,164(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000087379 -- 53,550,444(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000196410 -- 53,565,529(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF331 Gene

Variant ID Type Subtype PubMed ID
dgv3648n100 CNV gain 25217958
esv2642494 CNV deletion 19546169
esv2657469 CNV deletion 23128226
esv2718812 CNV deletion 23290073
esv2718825 CNV deletion 23290073
esv2718826 CNV deletion 23290073
esv2718827 CNV deletion 23290073
esv2718828 CNV deletion 23290073
esv2718830 CNV deletion 23290073
esv2762049 CNV gain 21179565
esv28878 CNV loss 19812545
esv3304051 CNV mobile element insertion 20981092
esv3309401 CNV mobile element insertion 20981092
esv3335697 CNV insertion 20981092
nsv1055718 CNV gain 25217958
nsv1055773 CNV gain 25217958
nsv1062035 CNV loss 25217958
nsv1063523 CNV gain 25217958
nsv1077867 CNV duplication 25765185
nsv1109213 CNV deletion 24896259
nsv1111176 CNV tandem duplication 24896259
nsv1128783 CNV duplication 24896259
nsv1146847 CNV duplication 26484159
nsv523944 CNV loss 19592680
nsv580107 CNV gain 21841781

Variation tolerance for ZNF331 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF331 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF331 Gene

Disorders for ZNF331 Gene

Additional Disease Information for ZNF331

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF331 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF331 Gene

Publications for ZNF331 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas. (PMID: 14610350) Meiboom M … Bullerdiek J (Cytogenetic and genome research 2003) 3 22 58
  4. Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463. (PMID: 11267678) Wu H … Milunsky A (Biochimica et biophysica acta 2001) 3 4 58
  5. A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors. (PMID: 10502321) Rippe V … Bullerdiek J (Genes, chromosomes & cancer 1999) 3 4 58

Products for ZNF331 Gene

Sources for ZNF331 Gene

Loading form....