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Aliases for PLCXD1 Gene

Aliases for PLCXD1 Gene

  • Phosphatidylinositol Specific Phospholipase C X Domain Containing 1 2 3 5
  • Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 1 2
  • PI-PLC X Domain-Containing Protein 1 3
  • LL0XNC01-136G2.1 3

External Ids for PLCXD1 Gene

Previous GeneCards Identifiers for PLCXD1 Gene

  • GC0YP000133
  • GC0XP000132

Summaries for PLCXD1 Gene

Entrez Gene Summary for PLCXD1 Gene

  • This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for PLCXD1 Gene

PLCXD1 (Phosphatidylinositol Specific Phospholipase C X Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD3.

Tocris Summary for PLCXD1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCXD1 Gene

Additional gene information for PLCXD1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCXD1 Gene

Genomics for PLCXD1 Gene

GeneHancer (GH) Regulatory Elements for PLCXD1 Gene

Promoters and enhancers for PLCXD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI000280 Promoter/Enhancer 2 EPDnew Ensembl dbSUPER 550.4 +6.0 5979 3.4 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 YY1 NCOA2 POLR2B GLIS2 PLCXD1 GTPBP6
GH0XI000275 Promoter/Enhancer 1.4 Ensembl dbSUPER 550.8 +0.3 279 1.6 PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF48 ZNF121 GLIS2 FOS SP3 PLCXD1 GTPBP6
GH0XI000278 Enhancer 0.9 dbSUPER 0.8 +3.2 3202 1.8 HDAC1 ARID4B DMAP1 TCF12 ATF7 THAP11 SP5 ZBTB2 NCOA1 REST PLCXD1 GTPBP6
GH0XI000261 Enhancer 0.9 Ensembl 0.4 -14.3 -14306 1.9 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 RXRA SP5 REST ENSG00000228572 PLCXD1
GH0XI000270 Enhancer 0.7 dbSUPER 0.4 -5.3 -5284 0.6 ELF3 KLF1 SAP130 THRB ZNF48 RARA NR2F6 MIXL1 GATAD2A TFE3 PLCXD1 ENSG00000228572
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLCXD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLCXD1 gene promoter:

Genomic Locations for PLCXD1 Gene

Genomic Locations for PLCXD1 Gene
27,035 bases
Plus strand

Genomic View for PLCXD1 Gene

Genes around PLCXD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCXD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCXD1 Gene

Proteins for PLCXD1 Gene

  • Protein details for PLCXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PI-PLC X domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A2BH51
    • A2BH52

    Protein attributes for PLCXD1 Gene

    323 amino acids
    Molecular mass:
    36668 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    • Sequence=CAM28359.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM28360.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLCXD1 Gene

Post-translational modifications for PLCXD1 Gene

No data available for DME Specific Peptides for PLCXD1 Gene

Domains & Families for PLCXD1 Gene

Gene Families for PLCXD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLCXD1 Gene

Suggested Antigen Peptide Sequences for PLCXD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCXD1: view

No data available for UniProtKB/Swiss-Prot for PLCXD1 Gene

Function for PLCXD1 Gene

Gene Ontology (GO) - Molecular Function for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCXD1: view
genes like me logo Genes that share phenotypes with PLCXD1: view

Animal Model Products

miRNA for PLCXD1 Gene

miRTarBase miRNAs that target PLCXD1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCXD1 Gene

Localization for PLCXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCXD1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCXD1 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLCXD1: view

Pathways & Interactions for PLCXD1 Gene

SuperPathways for PLCXD1 Gene

No Data Available

Interacting Proteins for PLCXD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NUJ7-PLCX1_HUMAN ENSP00000371073 for PLCXD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with PLCXD1: view

No data available for Pathways by source and SIGNOR curated interactions for PLCXD1 Gene

Drugs & Compounds for PLCXD1 Gene

(1) Drugs for PLCXD1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D609 Pharma PC-PLC inhibitor 0

(381) Additional Compounds for PLCXD1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)

(5) Tocris Compounds for PLCXD1 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(1) ApexBio Compounds for PLCXD1 Gene

Compound Action Cas Number
D609 PC-PLC inhibitor 83373-60-8
genes like me logo Genes that share compounds with PLCXD1: view

Drug Products

Transcripts for PLCXD1 Gene

Unigene Clusters for PLCXD1 Gene

Phosphatidylinositol-specific phospholipase C, X domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCXD1 Gene

No ASD Table

Relevant External Links for PLCXD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCXD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLCXD1 Gene:


SOURCE GeneReport for Unigene cluster for PLCXD1 Gene:


mRNA Expression by UniProt/SwissProt for PLCXD1 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PLCXD1 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with PLCXD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCXD1 Gene

Orthologs for PLCXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCXD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PLCXD1 33 34
  • 82.85 (n)
(Bos Taurus)
Mammalia PLCXD1 34
  • 80 (a)
-- 34
  • 67 (a)
-- 34
  • 65 (a)
(Monodelphis domestica)
Mammalia PLCXD1 34
  • 75 (a)
(Rattus norvegicus)
Mammalia LOC100909600 33
  • 74.61 (n)
(Mus musculus)
Mammalia Plcxd1 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia PLCXD1 34
  • 33 (a)
(Gallus gallus)
Aves PLCXD1 33 34
  • 61.92 (n)
(Anolis carolinensis)
Reptilia PLCXD1 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plcxd1 33
  • 55.52 (n)
(Danio rerio)
Actinopterygii LOC563489 33
  • 55.56 (n)
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10747 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea F38E9.1 34
  • 13 (a)
Species where no ortholog for PLCXD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCXD1 Gene

Gene Tree for PLCXD1 (if available)
Gene Tree for PLCXD1 (if available)

Paralogs for PLCXD1 Gene

Paralogs for PLCXD1 Gene

(2) SIMAP similar genes for PLCXD1 Gene using alignment to 3 proteins: Pseudogenes for PLCXD1 Gene

genes like me logo Genes that share paralogs with PLCXD1: view

Variants for PLCXD1 Gene

Sequence variations from dbSNP and Humsavar for PLCXD1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000189182 -- 286,410(+) C/T intron_variant
rs1000317355 -- 289,820(+) C/A/G intron_variant
rs1000327520 -- 290,033(+) C/T intron_variant
rs1000481119 -- 300,688(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000568628 -- 303,258(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLCXD1 Gene

Variant ID Type Subtype PubMed ID
nsv1153299 CNV duplication 26484159
nsv1147800 CNV duplication 26484159
nsv1140084 CNV duplication 24896259
nsv1137704 CNV deletion 24896259
nsv1132797 CNV duplication 24896259
nsv1125140 CNV duplication 24896259
nsv1077604 CNV duplication 25765185
nsv1076233 CNV deletion 25765185
nsv1075293 CNV deletion 25765185
esv3382952 CNV duplication 20981092
esv2969346 CNV duplication 24192839
esv27600 CNV gain+loss 19812545
esv2663649 CNV deletion 23128226
esv2658490 CNV deletion 23128226
esv1006189 CNV deletion 20482838
dgv4187n106 CNV deletion 24896259

Variation tolerance for PLCXD1 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLCXD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCXD1 Gene

Disorders for PLCXD1 Gene

Additional Disease Information for PLCXD1

No disorders were found for PLCXD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCXD1 Gene

Publications for PLCXD1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Cloning, tissue distribution and sub-cellular localisation of phospholipase C X-domain containing protein (PLCXD) isoforms. (PMID: 22732399) Gellatly SA … Cramb G (Biochemical and biophysical research communications 2012) 4 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for PLCXD1 Gene

Sources for PLCXD1 Gene

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