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Aliases for UEVLD Gene

Aliases for UEVLD Gene

  • UEV And Lactate/Malate Dehyrogenase Domains 2 3 5
  • EV And Lactate/Malate Dehydrogenase Domain-Containing Protein 3 4
  • UEV-3 3 4
  • UEV3 3 4
  • Ubiquitin-Conjugating Enzyme E2 Variant 3 3
  • Signaling Molecule ATTP 3
  • ATTP 3

External Ids for UEVLD Gene

Previous GeneCards Identifiers for UEVLD Gene

  • GC11M018510
  • GC11M018239

Summaries for UEVLD Gene

GeneCards Summary for UEVLD Gene

UEVLD (UEV And Lactate/Malate Dehyrogenase Domains) is a Protein Coding gene. Among its related pathways are protein ubiquitylation. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is LDHA.

UniProtKB/Swiss-Prot for UEVLD Gene

  • Possible negative regulator of polyubiquitination.

Additional gene information for UEVLD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UEVLD Gene

Genomics for UEVLD Gene

GeneHancer (GH) Regulatory Elements for UEVLD Gene

Promoters and enhancers for UEVLD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018587 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.5 -535 4.8 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF143 DEK SPTY2D1OS UEVLD SPTY2D1 LDHC TSG101 SAAL1 GTF2H1 LOC100129966 ENSG00000256361 SERGEF
GH11J018633 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.4 -45.3 -45308 2.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SPTY2D1 GC11P018635 LOC105376578 LDHC YWHABP2 UEVLD TSG101 ENSG00000279837
GH11J018697 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 4.8 -110.3 -110335 3.9 ATF1 SIN3A BRCA1 GLIS2 ZNF213 ATF7 SP3 RXRA SP5 NFYC TMEM86A PIR46171 GTF2H1 SPTY2D1 SAAL1 HPS5 IGSF22 LOC105376579 YWHABP2 UEVLD
GH11J018617 Enhancer 0.7 Ensembl ENCODE 5.5 -29.3 -29259 1.7 BCL11A CBFB SCRT2 ETV6 BATF RUNX3 CREM SPTY2D1 LOC105376579 IGSF22 LDHA UEVLD ENSG00000279837
GH11J018608 Enhancer 0.5 ENCODE 5.5 -19.7 -19702 1.1 ZNF148 MEIS2 NFIC PKNOX1 SPTY2D1 LOC105376579 IGSF22 GTF2H1 HPS5 UEVLD ENSG00000279837 SPTY2D1OS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UEVLD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UEVLD gene promoter:
  • Nkx6-1
  • CUTL1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • FOXO1
  • FOXO1a
  • Hlf

Genomic Locations for UEVLD Gene

Genomic Locations for UEVLD Gene
59,330 bases
Minus strand
59,139 bases
Minus strand

Genomic View for UEVLD Gene

Genes around UEVLD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UEVLD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UEVLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UEVLD Gene

Proteins for UEVLD Gene

  • Protein details for UEVLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 3
    Protein Accession:
    Secondary Accessions:
    • B2RB69
    • B4DL43
    • F5H6L6
    • H7BYD6
    • Q6P2F0
    • Q96FF5
    • Q9NUX7

    Protein attributes for UEVLD Gene

    471 amino acids
    Molecular mass:
    52264 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for UEVLD Gene

    Alternative splice isoforms for UEVLD Gene

neXtProt entry for UEVLD Gene

Post-translational modifications for UEVLD Gene

  • Ubiquitination at isoforms=2, 5, 745
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UEVLD Gene

Domains & Families for UEVLD Gene

Gene Families for UEVLD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
  • In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
  • In the C-terminal section; belongs to the LDH/MDH superfamily.
genes like me logo Genes that share domains with UEVLD: view

Function for UEVLD Gene

Molecular function for UEVLD Gene

UniProtKB/Swiss-Prot Function:
Possible negative regulator of polyubiquitination.

Phenotypes From GWAS Catalog for UEVLD Gene

Gene Ontology (GO) - Molecular Function for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with UEVLD: view
genes like me logo Genes that share phenotypes with UEVLD: view

Animal Models for UEVLD Gene

MGI Knock Outs for UEVLD:
  • Uevld Uevld<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for UEVLD

Clone Products

  • Addgene plasmids for UEVLD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UEVLD Gene

Localization for UEVLD Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UEVLD gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with UEVLD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UEVLD Gene

Pathways & Interactions for UEVLD Gene

SuperPathways for UEVLD Gene

SuperPathway Contained pathways
1 protein ubiquitylation
genes like me logo Genes that share pathways with UEVLD: view

Pathways by source for UEVLD Gene

1 BioSystems pathway for UEVLD Gene

Gene Ontology (GO) - Biological Process for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006464 cellular protein modification process IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0019752 carboxylic acid metabolic process IEA --
genes like me logo Genes that share ontologies with UEVLD: view

No data available for SIGNOR curated interactions for UEVLD Gene

Drugs & Compounds for UEVLD Gene

No Compound Related Data Available

Transcripts for UEVLD Gene

Unigene Clusters for UEVLD Gene

UEV and lactate/malate dehyrogenase domains:
Representative Sequences:

Clone Products

  • Addgene plasmids for UEVLD

Alternative Splicing Database (ASD) splice patterns (SP) for UEVLD Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: -
SP10: -
SP11: - - - - - - - -
SP12: - - -

ExUns: 15b ^ 16 ^ 17a · 17b · 17c · 17d
SP1: -
SP2: -
SP3: -

Relevant External Links for UEVLD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UEVLD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UEVLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UEVLD Gene

This gene is overexpressed in Urine (24.9) and Cervix (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UEVLD Gene

NURSA nuclear receptor signaling pathways regulating expression of UEVLD Gene:


SOURCE GeneReport for Unigene cluster for UEVLD Gene:


mRNA Expression by UniProt/SwissProt for UEVLD Gene:

Tissue specificity: Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for UEVLD Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with UEVLD: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UEVLD Gene

Orthologs for UEVLD Gene

This gene was present in the common ancestor of animals.

Orthologs for UEVLD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UEVLD 34 33
  • 99.5 (n)
(Canis familiaris)
Mammalia UEVLD 34 33
  • 91.79 (n)
(Bos Taurus)
Mammalia UEVLD 34 33
  • 91.3 (n)
(Mus musculus)
Mammalia Uevld 16 34 33
  • 85 (n)
(Rattus norvegicus)
Mammalia Uevld 33
  • 82.87 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
-- 34
  • 61 (a)
(Monodelphis domestica)
Mammalia UEVLD 34
  • 79 (a)
(Gallus gallus)
Aves UEVLD 34 33
  • 70.37 (n)
(Anolis carolinensis)
Reptilia UEVLD 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia uevld 33
  • 61.29 (n)
Str.204 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12325 33
(Danio rerio)
Actinopterygii uevld 34 33
  • 58.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 34
  • 34 (a)
CG13334 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea ldh-1 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 34
  • 33 (a)
Species where no ortholog for UEVLD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UEVLD Gene

Gene Tree for UEVLD (if available)
Gene Tree for UEVLD (if available)
Evolutionary constrained regions (ECRs) for UEVLD: view image

Paralogs for UEVLD Gene

Paralogs for UEVLD Gene

(6) SIMAP similar genes for UEVLD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UEVLD: view

Variants for UEVLD Gene

Sequence variations from dbSNP and Humsavar for UEVLD Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000053602 -- 18,555,093(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000063755 -- 18,556,736(-) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000077530 -- 18,536,083(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000109228 -- 18,584,373(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000117978 -- 18,549,784(-) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UEVLD Gene

Variant ID Type Subtype PubMed ID
esv2660842 CNV deletion 23128226
esv2761651 CNV loss 21179565
esv3625503 CNV loss 21293372
esv3625504 CNV loss 21293372
esv3625506 CNV loss 21293372
nsv553633 CNV gain 21841781

Variation tolerance for UEVLD Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UEVLD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UEVLD Gene

Disorders for UEVLD Gene

Additional Disease Information for UEVLD

No disorders were found for UEVLD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UEVLD Gene

Publications for UEVLD Gene

  1. Identification and characterization of UEV3, a human cDNA with similarities to inactive E2 ubiquitin-conjugating enzymes. (PMID: 12427560) Kloor M … Ridder R (Biochimica et biophysica acta 2002) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3 58

Products for UEVLD Gene

Sources for UEVLD Gene

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