Aliases for SLC47A1 Gene
External Ids for SLC47A1 Gene
Previous GeneCards Identifiers for SLC47A1 Gene
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC47A1 Gene
SLC47A1 (Solute Carrier Family 47 Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Gefitinib Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include antiporter activity and monovalent cation:proton antiporter activity. An important paralog of this gene is SLC47A2.
UniProtKB/Swiss-Prot for SLC47A1 Gene
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.