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Aliases for PPP2CB Gene

Aliases for PPP2CB Gene

  • Protein Phosphatase 2 Catalytic Subunit Beta 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform 2 3
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme 2 3
  • Protein Phosphatase 2A Catalytic Subunit, Beta Isoform 2 3
  • PP2A-Beta 3 4
  • Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform 3
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isoform 3
  • Protein Phosphatase Type 2A Catalytic Subunit 3
  • Testicular Tissue Protein Li 146 3
  • EC 4
  • PP2Abeta 3
  • PP2CB 3

External Ids for PPP2CB Gene

Previous GeneCards Identifiers for PPP2CB Gene

  • GC08M030548
  • GC08M031095
  • GC08M030499
  • GC08M030700
  • GC08M029189
  • GC08M030631

Summaries for PPP2CB Gene

Entrez Gene Summary for PPP2CB Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPP2CB Gene

PPP2CB (Protein Phosphatase 2 Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are ERK Signaling and mTOR Pathway. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP2CA.

UniProtKB/Swiss-Prot for PPP2CB Gene

  • PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Tocris Summary for PPP2CB Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2CB Gene

Additional gene information for PPP2CB Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CB Gene

Genomics for PPP2CB Gene

GeneHancer (GH) Regulatory Elements for PPP2CB Gene

Promoters and enhancers for PPP2CB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J030810 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 681.2 +2.0 2040 2.9 HDGF SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B PPP2CB GTF2E2 WRN PIR42776
GH08J030911 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 33.1 -98.2 -98152 1.8 ATF1 ARNT ARID4B ZNF2 POLR2B GLIS2 CBX5 E2F8 ARID2 ZFP91 TEX15 GTF2E2 PPP2CB LOC105379357
GH08J030800 Enhancer 1.3 Ensembl ENCODE dbSUPER 30.8 +11.0 10952 5.3 PKNOX1 FOXA2 ARID4B DMAP1 ZNF48 ETS1 YY1 ZNF121 FOS DEK PPP2CB PIR42776
GH08J030742 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 +70.2 70172 2.5 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B UBXN8 GC08M030742 LOC105379355 WRN GTF2E2 RPS15AP24 PPP2CB RNU5A-3P GSR
GH08J030652 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 6.3 +158.2 158228 6.3 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 GTF2E2 WRN SMIM18 PPP2CB RNU5A-3P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2CB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2CB gene promoter:
  • AREB6
  • POU2F1a
  • POU2F1
  • LUN-1
  • RSRFC4
  • TBP
  • RelA
  • COMP1
  • STAT1
  • c-Rel

Genomic Locations for PPP2CB Gene

Genomic Locations for PPP2CB Gene
39,858 bases
Minus strand
39,858 bases
Minus strand

Genomic View for PPP2CB Gene

Genes around PPP2CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CB Gene

Proteins for PPP2CB Gene

  • Protein details for PPP2CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
    Protein Accession:
    Secondary Accessions:
    • D3DSV4
    • P11082
    • Q6FHK5

    Protein attributes for PPP2CB Gene

    309 amino acids
    Molecular mass:
    35575 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGO1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL. Interacts with PTPA (PubMed:12952889).

neXtProt entry for PPP2CB Gene

Post-translational modifications for PPP2CB Gene

  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • May be monoubiquitinated by NOSIP.
  • Ubiquitination at posLast=2121
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CB Gene

No data available for DME Specific Peptides for PPP2CB Gene

Domains & Families for PPP2CB Gene

Gene Families for PPP2CB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PPP phosphatase family. PP-1 subfamily.
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CB: view

Function for PPP2CB Gene

Molecular function for PPP2CB Gene

UniProtKB/Swiss-Prot Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
GENATLAS Biochemistry:
protein phosphatase 2A,catalytic subunit,beta isoform

Enzyme Numbers (IUBMB) for PPP2CB Gene

Phenotypes From GWAS Catalog for PPP2CB Gene

Gene Ontology (GO) - Molecular Function for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 contributes_to protein serine/threonine phosphatase activity TAS,ISS 8206937
GO:0005515 protein binding IPI 9647778
GO:0008022 protein C-terminus binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP2CB: view
genes like me logo Genes that share phenotypes with PPP2CB: view

Animal Models for PPP2CB Gene

MGI Knock Outs for PPP2CB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP2CB

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CB Gene

Localization for PPP2CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CB Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2CB gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
cytoskeleton 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex TAS 8206937
GO:0000775 chromosome, centromeric region IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Pathways & Interactions for PPP2CB Gene

SuperPathways for PPP2CB Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
4 Negative regulation of FGFR1 signaling
5 PI3K/AKT activation
genes like me logo Genes that share pathways with PPP2CB: view

SIGNOR curated interactions for PPP2CB Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 2849765
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0010288 response to lead ion ISS --
GO:0010468 regulation of gene expression IEA --
GO:0034976 response to endoplasmic reticulum stress IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Drugs & Compounds for PPP2CB Gene

(13) Drugs for PPP2CB Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 434,438
alpha-Tocopherol acetate Approved, Vet_approved Nutra Target 0
alpha-Tocopherol succinate Approved, Vet_approved Nutra Target 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(3) Additional Compounds for PPP2CB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
FK 506

(4) Tocris Compounds for PPP2CB Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2CB: view

Transcripts for PPP2CB Gene

mRNA/cDNA for PPP2CB Gene

Unigene Clusters for PPP2CB Gene

Protein phosphatase 2, catalytic subunit, beta isozyme:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP5: - - - - - - - - - -

Relevant External Links for PPP2CB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP2CB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2CB Gene

This gene is overexpressed in Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2CB Gene

Protein tissue co-expression partners for PPP2CB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP2CB Gene:


SOURCE GeneReport for Unigene cluster for PPP2CB Gene:


Evidence on tissue expression from TISSUES for PPP2CB Gene

  • Nervous system(4.5)
  • Kidney(4.4)
  • Liver(4.4)
  • Eye(2)
genes like me logo Genes that share expression patterns with PPP2CB: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2CB Gene

Orthologs for PPP2CB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP2CB 33
  • 99.89 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
-- 34
  • 68 (a)
(Canis familiaris)
Mammalia PPP2CB 34 33
  • 95.15 (n)
(Bos Taurus)
Mammalia PPP2CB 34 33
  • 93.2 (n)
(Rattus norvegicus)
Mammalia Ppp2cb 33
  • 93.1 (n)
(Mus musculus)
Mammalia Ppp2cb 16 34 33
  • 92.13 (n)
(Ornithorhynchus anatinus)
Mammalia PPP2CB 34
  • 92 (a)
(Gallus gallus)
Aves PPP2CA 34
  • 97 (a)
  • 87.27 (n)
(Anolis carolinensis)
Reptilia PPP2CB 34
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2cb 33
  • 84.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6686 33
(Danio rerio)
Actinopterygii ppp2cb 34 33
  • 81.45 (n)
Dr.5120 33
fruit fly
(Drosophila melanogaster)
Insecta mts 34 35
  • 94 (a)
CG11597 35
  • 51 (a)
(Caenorhabditis elegans)
Secernentea F38H4.9 35
  • 89 (a)
let-92 34
  • 86 (a)
pph-4.1 35
  • 63 (a)
pph-4.2 35
  • 61 (a)
C34C12.3 35
  • 52 (a)
C25A6.1 35
  • 44 (a)
C06A1.3 35
  • 40 (a)
W03D8.2 35
  • 40 (a)
Y40H4A.2 35
  • 39 (a)
C23G10.1a 35
  • 38 (a)
C24H11.2 35
  • 38 (a)
C24H11.1 35
  • 38 (a)
C23G10.1b 35
  • 38 (a)
R13A5.11 35
  • 37 (a)
F58G1.3 35
  • 36 (a)
R08A2.2 35
  • 35 (a)
F42G8.8 35
  • 34 (a)
C27B7.6 35
  • 33 (a)
F49E11.7 35
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH22 34 33
  • 66.67 (n)
PPH21 36 34
  • 62 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05357g 33
  • 66.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR099C 33
  • 64.57 (n)
(Glycine max)
eudicotyledons Gma.10798 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9171 33
(Oryza sativa)
Liliopsida Os10g0410600 33
  • 71.44 (n)
(Triticum aestivum)
Liliopsida Ta.11307 33
(Hordeum vulgare)
Liliopsida Hv.6175 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11024 34
  • 90 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06630 33
  • 70 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa2 33
  • 68.73 (n)
Species where no ortholog for PPP2CB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP2CB Gene

Gene Tree for PPP2CB (if available)
Gene Tree for PPP2CB (if available)
Evolutionary constrained regions (ECRs) for PPP2CB: view image

Paralogs for PPP2CB Gene

Paralogs for PPP2CB Gene

(11) SIMAP similar genes for PPP2CB Gene using alignment to 6 proteins:

  • H0YC23_HUMAN Pseudogenes for PPP2CB Gene

genes like me logo Genes that share paralogs with PPP2CB: view

Variants for PPP2CB Gene

Sequence variations from dbSNP and Humsavar for PPP2CB Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000034624 -- 30,806,210(-) G/A intron_variant
rs1000154240 -- 30,812,288(-) C/T intron_variant
rs1000227299 -- 30,789,005(-) C/A intron_variant
rs1000323652 -- 30,806,421(-) G/A/T intron_variant
rs1000324121 -- 30,799,860(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2CB Gene

Variant ID Type Subtype PubMed ID
esv3386082 CNV insertion 20981092
nsv1077034 CNV deletion 25765185
nsv1144225 CNV deletion 24896259
nsv971635 CNV duplication 23825009

Variation tolerance for PPP2CB Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2CB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CB Gene

Disorders for PPP2CB Gene

Additional Disease Information for PPP2CB

No disorders were found for PPP2CB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2CB Gene

Publications for PPP2CB Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4 22 58
  2. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. (PMID: 8206937) Favre B … Hemmings BA (The Journal of biological chemistry 1994) 3 4 22 58
  3. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PMID: 1846293) Khew-Goodall Y … Hemmings BA (Biochemistry 1991) 3 4 22 58
  4. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PPP2CB Gene