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Aliases for SDAD1 Gene

Aliases for SDAD1 Gene

  • SDA1 Domain Containing 1 2 3 5
  • SDA1 Domain-Containing Protein 1 3 4
  • Nucleolar Protein 130 3 4
  • Protein SDA1 Homolog 3
  • NUC130 4
  • HSDA 4

External Ids for SDAD1 Gene

Previous GeneCards Identifiers for SDAD1 Gene

  • GC04M077330
  • GC04M077228
  • GC04M077090
  • GC04M076871
  • GC04M072623

Summaries for SDAD1 Gene

GeneCards Summary for SDAD1 Gene

SDAD1 (SDA1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SDAD1 include Rhinitis and Allergic Rhinitis. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for SDAD1 Gene

  • Required for 60S pre-ribosomal subunits export to the cytoplasm.

Gene Wiki entry for SDAD1 Gene

Additional gene information for SDAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDAD1 Gene

Genomics for SDAD1 Gene

GeneHancer (GH) Regulatory Elements for SDAD1 Gene

Promoters and enhancers for SDAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J075989 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 404 2.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 ZNF766 E2F8 SDAD1 NAAA SCARB2 ART3 LOC101928809 GC04M075923
GH04J076233 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 660.4 -245.0 -244957 5.5 SMAD1 ATF1 TAF9B NEUROD1 ZBTB40 CHAMP1 TCF12 POLR2B ZNF766 EGR1 SCARB2 SDAD1 FAM47E NUP54 THAP6 ENSG00000251185 STBD1 LOC105377286
GH04J076947 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.3 -959.3 -959289 5.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 KLF13 SEPT11 GC04M076939 LOC105377294 NUP54 CNOT6L RPL7P17 SDAD1 SOWAHB MRPL1 GC04P076953
GH04J076205 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.7 -219.8 -219832 10.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SCARB2 GC04P076210 NUP54 FAM47E THAP6 SDAD1 ART3 NAAA G3BP2 STBD1
GH04J076146 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 -157.2 -157209 2.5 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NUP54 GC04P076146 THAP6 ART3 RPL7P17 SDAD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SDAD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SDAD1 gene promoter:
  • IRF-1
  • Cdc5
  • IRF-2
  • FOXL1
  • Gfi-1
  • IRF-7A
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for SDAD1 Gene

Genomic Locations for SDAD1 Gene
chr4:75,940,950-75,990,962
(GRCh38/hg38)
Size:
50,013 bases
Orientation:
Minus strand
chr4:76,862,103-76,912,115
(GRCh37/hg19)
Size:
50,013 bases
Orientation:
Minus strand

Genomic View for SDAD1 Gene

Genes around SDAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDAD1 Gene

Proteins for SDAD1 Gene

  • Protein details for SDAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVU7-SDA1_HUMAN
    Recommended name:
    Protein SDA1 homolog
    Protein Accession:
    Q9NVU7
    Secondary Accessions:
    • Q32Q11
    • Q68D52
    • Q7Z5U4
    • Q9H831
    • Q9H9P6

    Protein attributes for SDAD1 Gene

    Size:
    687 amino acids
    Molecular mass:
    79871 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DAZL and PUM2 bind its 3-UTR mRNA, suggesting that these proteins may regulate its translation.
    SequenceCaution:
    • Sequence=AAI07896.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91648.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305}; Sequence=BAB14177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SDAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDAD1 Gene

Post-translational modifications for SDAD1 Gene

  • Ubiquitination at posLast=2121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDAD1 Gene

Domains & Families for SDAD1 Gene

Gene Families for SDAD1 Gene

Protein Domains for SDAD1 Gene

Suggested Antigen Peptide Sequences for SDAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVU7

UniProtKB/Swiss-Prot:

SDA1_HUMAN :
  • Belongs to the SDA1 family.
Family:
  • Belongs to the SDA1 family.
genes like me logo Genes that share domains with SDAD1: view

Function for SDAD1 Gene

Molecular function for SDAD1 Gene

UniProtKB/Swiss-Prot Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.

Phenotypes From GWAS Catalog for SDAD1 Gene

Gene Ontology (GO) - Molecular Function for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with SDAD1: view
genes like me logo Genes that share phenotypes with SDAD1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDAD1 Gene

Localization for SDAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDAD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDAD1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 11790298
genes like me logo Genes that share ontologies with SDAD1: view

Pathways & Interactions for SDAD1 Gene

SuperPathways for SDAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IEA --
GO:0015031 protein transport IEA --
GO:0030036 actin cytoskeleton organization IBA,IEA --
GO:0042254 ribosome biogenesis IEA --
GO:0042273 ribosomal large subunit biogenesis IEA,ISS --
genes like me logo Genes that share ontologies with SDAD1: view

No data available for Pathways by source and SIGNOR curated interactions for SDAD1 Gene

Drugs & Compounds for SDAD1 Gene

No Compound Related Data Available

Transcripts for SDAD1 Gene

Unigene Clusters for SDAD1 Gene

SDA1 domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for SDAD1 Gene

GeneLoc Exon Structure for
SDAD1
ECgene alternative splicing isoforms for
SDAD1

Expression for SDAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDAD1 Gene

Protein differential expression in normal tissues from HIPED for SDAD1 Gene

This gene is overexpressed in Lung (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SDAD1 Gene



Protein tissue co-expression partners for SDAD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDAD1 Gene:

SDAD1

SOURCE GeneReport for Unigene cluster for SDAD1 Gene:

Hs.632604

mRNA Expression by UniProt/SwissProt for SDAD1 Gene:

Q9NVU7-SDA1_HUMAN
Tissue specificity: Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.

Evidence on tissue expression from TISSUES for SDAD1 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SDAD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDAD1 Gene

Orthologs for SDAD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDAD1 34 33
  • 99.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SDAD1 34 33
  • 91.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SDAD1 34 33
  • 89.59 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDAD1 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdad1 16 34 33
  • 87.82 (n)
rat
(Rattus norvegicus)
Mammalia Sdad1 33
  • 86.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SDAD1 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDAD1 34 33
  • 77.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDAD1 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdad1 33
  • 74.31 (n)
Str.17243 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398506 33
zebrafish
(Danio rerio)
Actinopterygii sdad1 34 33
  • 73.24 (n)
OneToOne
flj10498 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1827 33
fruit fly
(Drosophila melanogaster)
Insecta Mys45A 34 33
  • 57.21 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pro-3 34 33
  • 51.27 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL212W 33
  • 46.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDA1 36 34
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6735 34
  • 55 (a)
OneToOne
Cin.4149 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4149 33
Species where no ortholog for SDAD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDAD1 Gene

ENSEMBL:
Gene Tree for SDAD1 (if available)
TreeFam:
Gene Tree for SDAD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SDAD1: view image

Paralogs for SDAD1 Gene

genes like me logo Genes that share paralogs with SDAD1: view

No data available for Paralogs for SDAD1 Gene

Variants for SDAD1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SDAD1 Gene

SDA1_HUMAN-Q9NVU7
Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.

Sequence variations from dbSNP and Humsavar for SDAD1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000124122 -- 75,949,462(-) C/A downstream_transcript_variant
rs1000170419 -- 75,950,178(-) G/A 3_prime_UTR_variant
rs1000225081 -- 75,949,871(-) G/A downstream_transcript_variant
rs1000242925 -- 75,991,061(-) G/A/T upstream_transcript_variant
rs1000250167 -- 75,960,714(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SDAD1 Gene

Variant ID Type Subtype PubMed ID
esv3449791 CNV insertion 20981092
nsv7363 OTHER inversion 18451855
nsv967764 CNV duplication 23825009

Variation tolerance for SDAD1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDAD1

SNP Genotyping and Copy Number Assay Products

Disorders for SDAD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SDAD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rhinitis
  • runny nose
allergic rhinitis
  • alrh
- elite association - COSMIC cancer census association via MalaCards
Search SDAD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SDAD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SDAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDAD1 Gene

Publications for SDAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 44 58
  3. Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind. (PMID: 15607425) Fox M … Reijo Pera RA (Genomics 2005) 3 4 58
  4. Association of a haplotype block spanning SDAD1 gene and CXC chemokine genes with allergic rhinitis. (PMID: 15753903) Zhang J … Arinami T (The Journal of allergy and clinical immunology 2005) 4 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SDAD1 Gene

Sources for SDAD1 Gene

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