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Aliases for TRIM68 Gene

Aliases for TRIM68 Gene

  • Tripartite Motif Containing 68 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM68 3 4
  • Tripartite Motif-Containing Protein 68 3 4
  • Ring Finger Protein 137 2 3
  • SSA Protein SS-56 3 4
  • RNF137 3 4
  • GC109 3 4
  • SS-56 3 4
  • SS56 3 4
  • E3 Ubiquitin-Protein Ligase TRIM68 3
  • Tripartite Motif-Containing 68 2
  • Ro/SSA1 Related Protein 3
  • RING Finger Protein 137 4
  • EC 4

External Ids for TRIM68 Gene

Previous HGNC Symbols for TRIM68 Gene

  • RNF137

Previous GeneCards Identifiers for TRIM68 Gene

  • GC11M004278

Summaries for TRIM68 Gene

Entrez Gene Summary for TRIM68 Gene

  • This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for TRIM68 Gene

TRIM68 (Tripartite Motif Containing 68) is a Protein Coding gene. Diseases associated with TRIM68 include Prostate Cancer. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include ligase activity and androgen receptor binding. An important paralog of this gene is TRIM21.

UniProtKB/Swiss-Prot for TRIM68 Gene

  • Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.

Gene Wiki entry for TRIM68 Gene

Additional gene information for TRIM68 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM68 Gene

Genomics for TRIM68 Gene

GeneHancer (GH) Regulatory Elements for TRIM68 Gene

Promoters and enhancers for TRIM68 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004606 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 658 +0.3 260 2.3 PKNOX1 SMAD1 ATF1 SIN3A ZNF2 YY1 POLR2B GLIS2 ZNF207 ZNF143 TRIM68 RRM1 NUP98 OR52I1
GH11J003795 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +811.0 811048 3.9 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 NUP98 PGAP2 CARS-AS1 TRIM68 GC11P003794 GC11M003657 GC11M003656
GH11J003852 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +750.7 750739 9.9 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 STIM1 MIR4687 LOC105376527 ENSG00000206976 OSBPL5 TSSC2 TRIM68 RHOG RRM1 PPIAP40
GH11J004392 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 10.1 +214.8 214779 1.7 HDGF PKNOX1 SIN3A DMAP1 IRF4 POLR2B GLIS2 ZNF143 ZFP91 ATF7 TRIM21 OR52K3P TRIM68 OR52K2 OR52B3P
GH11J003915 Enhancer 1 Ensembl ENCODE dbSUPER 14.4 +692.1 692090 0.7 GATAD2A NFIA RXRA NFIB ZNF384 ZNF491 RAD21 SP1 LCORL NFIC TRIM68 STIM1 GC11P003920 GC11P003897
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM68 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM68 gene promoter:
  • MyoD
  • NF-1/L
  • NF-1
  • AP-4
  • GR-beta
  • GR-alpha
  • GR
  • NRSF form 2

Genomic Locations for TRIM68 Gene

Genomic Locations for TRIM68 Gene
9,588 bases
Minus strand
9,588 bases
Minus strand

Genomic View for TRIM68 Gene

Genes around TRIM68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM68 Gene

Proteins for TRIM68 Gene

  • Protein details for TRIM68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM68
    Protein Accession:
    Secondary Accessions:
    • A6NI19
    • A8K551
    • B3KPM5
    • B4DVK4
    • Q8WZ70
    • Q96LE5
    • Q96PF7
    • Q9H9C2
    • Q9NW18

    Protein attributes for TRIM68 Gene

    485 amino acids
    Molecular mass:
    56259 Da
    Quaternary structure:
    • Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.
    • Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary Sjoegren syndrome.
    • Sequence=BAA91569.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14309.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM68 Gene


neXtProt entry for TRIM68 Gene

Post-translational modifications for TRIM68 Gene

Other Protein References for TRIM68 Gene

No data available for DME Specific Peptides for TRIM68 Gene

Domains & Families for TRIM68 Gene

Gene Families for TRIM68 Gene

Suggested Antigen Peptide Sequences for TRIM68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING domain is essential for ubiquitin E3 ligase activity.
  • Belongs to the TRIM/RBCC family.
  • The RING domain is essential for ubiquitin E3 ligase activity.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM68: view

Function for TRIM68 Gene

Molecular function for TRIM68 Gene

UniProtKB/Swiss-Prot Function:
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Induction:
Up-regulated in prostate cancer.

Enzyme Numbers (IUBMB) for TRIM68 Gene

Phenotypes From GWAS Catalog for TRIM68 Gene

Gene Ontology (GO) - Molecular Function for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18451177
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0035035 histone acetyltransferase binding IPI 18451177
genes like me logo Genes that share ontologies with TRIM68: view
genes like me logo Genes that share phenotypes with TRIM68: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM68 Gene

Localization for TRIM68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM68 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM68 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 18451177
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TRIM68: view

Pathways & Interactions for TRIM68 Gene

genes like me logo Genes that share pathways with TRIM68: view

Pathways by source for TRIM68 Gene

UniProtKB/Swiss-Prot Q6AZZ1-TRI68_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0051865 protein autoubiquitination IDA 18451177
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:0060765 regulation of androgen receptor signaling pathway IDA 18451177
genes like me logo Genes that share ontologies with TRIM68: view

No data available for SIGNOR curated interactions for TRIM68 Gene

Drugs & Compounds for TRIM68 Gene

No Compound Related Data Available

Transcripts for TRIM68 Gene

mRNA/cDNA for TRIM68 Gene

Unigene Clusters for TRIM68 Gene

Tripartite motif containing 68:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM68 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for TRIM68 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM68 Gene

Protein differential expression in normal tissues from HIPED for TRIM68 Gene

This gene is overexpressed in Colon muscle (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM68 Gene

Protein tissue co-expression partners for TRIM68 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM68 Gene:


SOURCE GeneReport for Unigene cluster for TRIM68 Gene:


mRNA Expression by UniProt/SwissProt for TRIM68 Gene:

Tissue specificity: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.

Evidence on tissue expression from TISSUES for TRIM68 Gene

  • Spleen(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TRIM68: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM68 Gene

Orthologs for TRIM68 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM68 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM68 34 33
  • 99.31 (n)
(Canis familiaris)
Mammalia TRIM68 34 33
  • 89.07 (n)
(Bos Taurus)
Mammalia TRIM68 34 33
  • 87.84 (n)
(Rattus norvegicus)
Mammalia Trim68 33
  • 81.32 (n)
(Mus musculus)
Mammalia Trim68 16 34 33
  • 80.99 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
-- 34
  • 35 (a)
-- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 30 (a)
Species where no ortholog for TRIM68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM68 Gene

Gene Tree for TRIM68 (if available)
Gene Tree for TRIM68 (if available)
Evolutionary constrained regions (ECRs) for TRIM68: view image

Paralogs for TRIM68 Gene

(38) SIMAP similar genes for TRIM68 Gene using alignment to 4 proteins:

  • E9PP83_HUMAN
  • E9PR29_HUMAN
genes like me logo Genes that share paralogs with TRIM68: view

Variants for TRIM68 Gene

Sequence variations from dbSNP and Humsavar for TRIM68 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000168651 -- 4,598,237(-) T/C downstream_transcript_variant
rs1000449222 -- 4,603,710(-) T/A intron_variant
rs1000800529 -- 4,603,434(-) C/T intron_variant
rs1000804845 -- 4,605,993(-) T/C intron_variant
rs1000873734 -- 4,607,776(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM68 Gene

Variant ID Type Subtype PubMed ID
dgv1586n54 CNV loss 21841781
nsv1047344 CNV loss 25217958
nsv1054705 CNV loss 25217958
nsv832055 CNV loss 17160897

Variation tolerance for TRIM68 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM68 Gene

Disorders for TRIM68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM68 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM68

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM68 Gene

Publications for TRIM68 Gene

  1. A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells. (PMID: 11597395) Chang GT … Brinkmann AO (European journal of cancer (Oxford, England : 1990) 2001) 2 3 4 58
  2. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PMID: 19795399) Malhotra A … Family Investigation of Nephropathy and Diabetes Research Group (Diabetes/metabolism research and reviews 2009) 3 44 58
  3. TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. (PMID: 18451177) Miyajima N … Hatakeyama S (Cancer research 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TRIM68 Gene

Sources for TRIM68 Gene

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