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Aliases for AKIRIN2 Gene

Aliases for AKIRIN2 Gene

  • Akirin 2 2 3 5
  • C6orf166 3 4
  • Fourteen-Three-Three Beta Interactant 1 3
  • Chromosome 6 Open Reading Frame 166 2
  • DJ486L4.2 3
  • Akirin-2 3
  • FBI1 3

External Ids for AKIRIN2 Gene

Previous HGNC Symbols for AKIRIN2 Gene

  • C6orf166

Previous GeneCards Identifiers for AKIRIN2 Gene

  • GC06M088442
  • GC06M085599
  • GC06M088384

Summaries for AKIRIN2 Gene

GeneCards Summary for AKIRIN2 Gene

AKIRIN2 (Akirin 2) is a Protein Coding gene. Diseases associated with AKIRIN2 include Listeriosis. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is AKIRIN1.

UniProtKB/Swiss-Prot for AKIRIN2 Gene

  • Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).

Gene Wiki entry for AKIRIN2 Gene

Additional gene information for AKIRIN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKIRIN2 Gene

Genomics for AKIRIN2 Gene

GeneHancer (GH) Regulatory Elements for AKIRIN2 Gene

Promoters and enhancers for AKIRIN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J087697 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.5 +1.9 1910 6.6 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D AKIRIN2 GC06M087700 SLC35A1 ENSG00000272008 ORC3 ZNF292 LINC01590 RARS2 SMIM8 GC06P087659
GH06J087729 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.5 -29.4 -29406 3.8 PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 JUNB AKIRIN2 SLC35A1 ORC3 ENSG00000238628 GC06P087742
GH06J087741 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 28.7 -40.1 -40109 1.1 PKNOX1 NFRKB YY1 ZNF766 ATF7 ETV6 IKZF2 RUNX3 CREM CAVIN1 GC06P087742 AKIRIN2 ZNF292 RARS2 LOC101928911
GH06J087755 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 26.7 -54.5 -54549 2.2 FEZF1 IRF4 TCF12 GATA2 ZNF143 FOS ATF7 RUNX3 RXRA NCOA1 AKIRIN2 RARS2 ENSG00000238628 ZNF292 ORC3 GC06P087742 LOC101928911
GH06J087788 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.6 -87.9 -87899 3.3 ELF3 FOXA2 ARID4B RARA YY1 ZNF335 ZNF366 SCRT2 FOS CREM AKIRIN2 ENSG00000238628 PIR51509 LOC101928911 GC06M087798
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKIRIN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AKIRIN2 gene promoter:
  • MEF-2A
  • aMEF-2
  • Egr-3
  • Sp1
  • Sox5
  • MRF-2
  • AML1a
  • Bach1
  • ITF-2

Genomic Locations for AKIRIN2 Gene

Genomic Locations for AKIRIN2 Gene
chr6:87,674,860-87,702,267
(GRCh38/hg38)
Size:
27,408 bases
Orientation:
Minus strand
chr6:88,384,578-88,411,985
(GRCh37/hg19)
Size:
27,408 bases
Orientation:
Minus strand

Genomic View for AKIRIN2 Gene

Genes around AKIRIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKIRIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKIRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKIRIN2 Gene

Proteins for AKIRIN2 Gene

  • Protein details for AKIRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H80-AKIR2_HUMAN
    Recommended name:
    Akirin-2
    Protein Accession:
    Q53H80
    Secondary Accessions:
    • Q9BQB1

    Protein attributes for AKIRIN2 Gene

    Size:
    203 amino acids
    Molecular mass:
    22496 Da
    Quaternary structure:
    • Interacts with YWHAB.
    Miscellaneous:
    • Akiraka ni suru means making things clear in Japanese. The name is given based on the presence of the clear nuclear localization signal.

neXtProt entry for AKIRIN2 Gene

Post-translational modifications for AKIRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKIRIN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKIRIN2 Gene

Domains & Families for AKIRIN2 Gene

Gene Families for AKIRIN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AKIRIN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKIRIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53H80

UniProtKB/Swiss-Prot:

AKIR2_HUMAN :
  • Belongs to the akirin family.
Family:
  • Belongs to the akirin family.
genes like me logo Genes that share domains with AKIRIN2: view

Function for AKIRIN2 Gene

Molecular function for AKIRIN2 Gene

UniProtKB/Swiss-Prot Function:
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).

Gene Ontology (GO) - Molecular Function for AKIRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with AKIRIN2: view
genes like me logo Genes that share phenotypes with AKIRIN2: view

Animal Models for AKIRIN2 Gene

MGI Knock Outs for AKIRIN2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKIRIN2 Gene

Localization for AKIRIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKIRIN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKIRIN2 gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AKIRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18066067
GO:0005654 nucleoplasm IDA --
GO:0017053 transcriptional repressor complex ISS,IEA --
genes like me logo Genes that share ontologies with AKIRIN2: view

Pathways & Interactions for AKIRIN2 Gene

SuperPathways for AKIRIN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKIRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with AKIRIN2: view

No data available for Pathways by source and SIGNOR curated interactions for AKIRIN2 Gene

Drugs & Compounds for AKIRIN2 Gene

No Compound Related Data Available

Transcripts for AKIRIN2 Gene

mRNA/cDNA for AKIRIN2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(209) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AKIRIN2 Gene

Akirin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKIRIN2 Gene

No ASD Table

Relevant External Links for AKIRIN2 Gene

GeneLoc Exon Structure for
AKIRIN2
ECgene alternative splicing isoforms for
AKIRIN2

Expression for AKIRIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKIRIN2 Gene

mRNA differential expression in normal tissues according to GTEx for AKIRIN2 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for AKIRIN2 Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKIRIN2 Gene



Protein tissue co-expression partners for AKIRIN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of AKIRIN2 Gene:

AKIRIN2

SOURCE GeneReport for Unigene cluster for AKIRIN2 Gene:

Hs.485915

mRNA Expression by UniProt/SwissProt for AKIRIN2 Gene:

Q53H80-AKIR2_HUMAN
Tissue specificity: Widely expressed with the highest expression in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for AKIRIN2 Gene

  • Nervous system(4.8)
  • Muscle(2.9)
  • Lung(2.3)
  • Heart(2.1)
  • Liver(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with AKIRIN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKIRIN2 Gene

Orthologs for AKIRIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKIRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKIRIN2 34 33
  • 99.67 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKIRIN2 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKIRIN2 34 33
  • 95.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AKIRIN2 34 33
  • 94.75 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKIRIN2 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akirin2 16 34 33
  • 90.05 (n)
rat
(Rattus norvegicus)
Mammalia Akirin2 33
  • 89.39 (n)
chicken
(Gallus gallus)
Aves AKIRIN2 34 33
  • 87.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKIRIN2 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akirin2 33
  • 79.44 (n)
MGC76154 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7326 33
zebrafish
(Danio rerio)
Actinopterygii akirin2 34 33
  • 72.59 (n)
OneToOne
Dr.4764 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006809 33
  • 53.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta akirin 34 33
  • 48.05 (n)
OneToMany
Species where no ortholog for AKIRIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKIRIN2 Gene

ENSEMBL:
Gene Tree for AKIRIN2 (if available)
TreeFam:
Gene Tree for AKIRIN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AKIRIN2: view image

Paralogs for AKIRIN2 Gene

Paralogs for AKIRIN2 Gene

(1) SIMAP similar genes for AKIRIN2 Gene using alignment to 1 proteins:

  • AKIR2_HUMAN
genes like me logo Genes that share paralogs with AKIRIN2: view

Variants for AKIRIN2 Gene

Sequence variations from dbSNP and Humsavar for AKIRIN2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000000408 -- 87,693,009(-) A/G intron_variant
rs1000178217 -- 87,697,091(-) C/G intron_variant
rs1000200019 -- 87,693,325(-) C/A/T intron_variant
rs1000235195 -- 87,698,098(-) T/C intron_variant
rs1000321650 -- 87,687,742(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AKIRIN2 Gene

Variant ID Type Subtype PubMed ID
dgv6085n100 CNV gain 25217958
esv2759454 CNV loss 17122850
esv3571280 CNV loss 25503493
esv3609867 CNV loss 21293372
nsv7941 CNV gain 18304495
nsv950478 CNV duplication 24416366

Variation tolerance for AKIRIN2 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKIRIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKIRIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKIRIN2 Gene

Disorders for AKIRIN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AKIRIN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
listeriosis
  • infection by listeria monocytogenes
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AKIRIN2

genes like me logo Genes that share disorders with AKIRIN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKIRIN2 Gene

Publications for AKIRIN2 Gene

  1. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. (PMID: 18066067) Goto A … Reichhart JM (Nature immunology 2008) 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for AKIRIN2 Gene

Sources for AKIRIN2 Gene

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