Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DMAC2 Gene

Aliases for DMAC2 Gene

  • Distal Membrane Arm Assembly Complex 2 2 3 5
  • ATP Synthase Subunit S-Like Protein 3 4
  • ATP5S Like 2 3
  • ATP5SL 3 4
  • Distal Membrane-Arm Assembly Complex Protein 2 3

External Ids for DMAC2 Gene

Previous HGNC Symbols for DMAC2 Gene

  • ATP5SL

Summaries for DMAC2 Gene

GeneCards Summary for DMAC2 Gene

DMAC2 (Distal Membrane Arm Assembly Complex 2) is a Protein Coding gene. An important paralog of this gene is ATP5S.

UniProtKB/Swiss-Prot for DMAC2 Gene

  • Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.

Gene Wiki entry for DMAC2 Gene

Additional gene information for DMAC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMAC2 Gene

Genomics for DMAC2 Gene

GeneHancer (GH) Regulatory Elements for DMAC2 Gene

Promoters and enhancers for DMAC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041438 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 660.9 +8.2 8152 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B DMAC2 GC19M041438 ZNF526 CCDC97 SNRPA EXOSC5 HNRNPUL1 ENSG00000269843 SERTAD3 ITPKC
GH19J041449 Enhancer 1.1 Ensembl ENCODE 650.7 -1.6 -1574 0.8 SIN3A ZNF2 ZNF48 GLIS2 ARID2 ZNF143 ATF7 KLF13 SP3 REST DMAC2 GC19P041489
GH19J041424 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 21.7 +20.8 20815 5 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF766 GLIS2 B3GNT8 ENSG00000268475 TMEM91 EXOSC5 DMAC2 ZNF574 SPTBN4 BCKDHA TGFB1 MEGF8
GH19J041406 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.2 +39.1 39087 4.3 FOXA2 ZNF614 FOS ZNF362 CEBPB ZBTB25 ZEB2 SP1 CEBPA MYC TMEM91 DMAC2 EXOSC5 TGFB1 B9D2 ERICH4 CCDC97 C19orf54 HNRNPUL1 ARHGEF1
GH19J041547 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.8 -104.9 -104900 10.5 HDGF HDAC1 PKNOX1 SMAD1 ZBTB7B ZNF335 SCRT2 ETV6 IKZF2 RUNX3 ENSG00000280014 CEACAMP3 CEACAM21 DMAC2 ERICH4 EXOSC5 BCKDHA LINC01480 ENSG00000268355 TMEM91
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DMAC2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DMAC2 Gene

Genomic Locations for DMAC2 Gene
16,510 bases
Minus strand
9,400 bases
Minus strand

Genomic View for DMAC2 Gene

Genes around DMAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMAC2 Gene

Proteins for DMAC2 Gene

  • Protein details for DMAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Distal membrane-arm assembly complex protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DDC0
    • B4DMZ4
    • B4DP55
    • B4DXE8
    • F5H4W7
    • K7EMF6
    • Q96D43

    Protein attributes for DMAC2 Gene

    257 amino acids
    Molecular mass:
    29267 Da
    Quaternary structure:
    • Interacts with incompletely assembled mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).

    Alternative splice isoforms for DMAC2 Gene

neXtProt entry for DMAC2 Gene

Post-translational modifications for DMAC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DMAC2 Gene

Domains & Families for DMAC2 Gene

Gene Families for DMAC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DMAC2 Gene


Suggested Antigen Peptide Sequences for DMAC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATP synthase subunit s family.
  • Belongs to the ATP synthase subunit s family.
genes like me logo Genes that share domains with DMAC2: view

Function for DMAC2 Gene

Molecular function for DMAC2 Gene

UniProtKB/Swiss-Prot Function:
Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.

Phenotypes From GWAS Catalog for DMAC2 Gene

genes like me logo Genes that share phenotypes with DMAC2: view

Animal Model Products

miRNA for DMAC2 Gene

miRTarBase miRNAs that target DMAC2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMAC2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DMAC2 Gene

Localization for DMAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMAC2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMAC2 gene
Compartment Confidence
mitochondrion 4
nucleus 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DMAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005747 colocalizes_with mitochondrial respiratory chain complex I IDA 27626371
genes like me logo Genes that share ontologies with DMAC2: view

Pathways & Interactions for DMAC2 Gene

SuperPathways for DMAC2 Gene

No Data Available

Interacting Proteins for DMAC2 Gene

Gene Ontology (GO) - Biological Process for DMAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 27626371
genes like me logo Genes that share ontologies with DMAC2: view

No data available for Pathways by source and SIGNOR curated interactions for DMAC2 Gene

Drugs & Compounds for DMAC2 Gene

No Compound Related Data Available

Transcripts for DMAC2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMAC2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMAC2 Gene

No ASD Table

Relevant External Links for DMAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DMAC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DMAC2 Gene:


Evidence on tissue expression from TISSUES for DMAC2 Gene

  • Lung(4.9)
  • Bone marrow(4.2)
  • Nervous system(4.2)
  • Muscle(2.4)
  • Heart(2.1)
  • Intestine(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMAC2 Gene

Orthologs for DMAC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP5SL 34 33
  • 98.18 (n)
(Bos Taurus)
Mammalia ATP5SL 34 33
  • 81.32 (n)
(Canis familiaris)
Mammalia ATP5SL 34 33
  • 78.86 (n)
(Mus musculus)
Mammalia Atp5sl 34 33
  • 76.13 (n)
Dmac2 16
(Rattus norvegicus)
Mammalia Atp5sl 33
  • 75.59 (n)
(Anolis carolinensis)
Reptilia ATP5SL 34
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5sl 33
  • 55.82 (n)
(Danio rerio)
Actinopterygii si:ch1073-228b5.2 33
  • 50.41 (n)
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4042 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea Y53G8AR.8 34
  • 15 (a)
Species where no ortholog for DMAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMAC2 Gene

Gene Tree for DMAC2 (if available)
Gene Tree for DMAC2 (if available)
Evolutionary constrained regions (ECRs) for DMAC2: view image

Paralogs for DMAC2 Gene

Paralogs for DMAC2 Gene

genes like me logo Genes that share paralogs with DMAC2: view

Variants for DMAC2 Gene

Sequence variations from dbSNP and Humsavar for DMAC2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000057048 -- 41,443,154(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000173416 -- 41,440,070(-) G/A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000399431 -- 41,434,106(-) G/A intron_variant
rs1000673815 -- 41,439,809(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000798840 -- 41,434,478(-) A/G intron_variant

Variation tolerance for DMAC2 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DMAC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DMAC2 Gene

Disorders for DMAC2 Gene

No disorders were found for DMAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMAC2 Gene

Publications for DMAC2 Gene

  1. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Assembly factors for the membrane arm of human complex I. (PMID: 24191001) Andrews B … Walker JE (Proceedings of the National Academy of Sciences of the United States of America 2013) 4 58

Products for DMAC2 Gene

Sources for DMAC2 Gene

Loading form....