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Aliases for TIPIN Gene

Aliases for TIPIN Gene

  • TIMELESS Interacting Protein 2 3 5
  • TIMELESS-Interacting Protein 3
  • CSM3 Homolog (S. Cerevisiae) 2
  • CSM3 Homolog 3

External Ids for TIPIN Gene

Previous GeneCards Identifiers for TIPIN Gene

  • GC15M064417
  • GC15M066629
  • GC15M043465

Summaries for TIPIN Gene

Entrez Gene Summary for TIPIN Gene

  • The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TIPIN Gene

TIPIN (TIMELESS Interacting Protein) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair.

UniProtKB/Swiss-Prot for TIPIN Gene

  • Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.

Gene Wiki entry for TIPIN Gene

Additional gene information for TIPIN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPIN Gene

Genomics for TIPIN Gene

GeneHancer (GH) Regulatory Elements for TIPIN Gene

Promoters and enhancers for TIPIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J066385 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 703.8 -2.3 -2333 6.5 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 TIPIN MAP2K1 SNAPC5 ZWILCH INTS14 SLC24A1 RPL35AP32 ENSG00000260773 SNORD16 DIS3L
GH15J066355 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 704.2 +30.1 30095 1.9 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 TIPIN RPL35AP32 INTS14 SNORD16 SNAPC5 ENSG00000260773 ZWILCH DENND4A DIS3L ENSG00000223271
GH15J066495 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 49.5 -110.5 -110462 3.9 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNAPC5 MIR4512 TIPIN ENSG00000260773 SLC24A1 RPL4 ZWILCH HACD3 SMAD3 DENND4A
GH15J066502 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.9 -117.5 -117500 4.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A SNORD16 ZWILCH RPL4 SNORD18A PIR57266 GC15M066541 GC15M066539 INTS14 ENSG00000260773 RPL35AP32
GH15J065609 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 32.5 +775.3 775334 3.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 INTS14 SLC24A1 ENSG00000260773 PARP16 SNORD16 RPL35AP32 PDCD7 ENSG00000264937 ENSG00000259635 TIPIN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIPIN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIPIN gene promoter:
  • STAT3
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for TIPIN Gene

Genomic Locations for TIPIN Gene
chr15:66,336,191-66,386,746
(GRCh38/hg38)
Size:
50,556 bases
Orientation:
Minus strand
chr15:66,628,544-66,679,084
(GRCh37/hg19)
Size:
50,541 bases
Orientation:
Minus strand

Genomic View for TIPIN Gene

Genes around TIPIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIPIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIPIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPIN Gene

Proteins for TIPIN Gene

  • Protein details for TIPIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVW5-TIPIN_HUMAN
    Recommended name:
    TIMELESS-interacting protein
    Protein Accession:
    Q9BVW5
    Secondary Accessions:
    • B2CW64
    • Q9NWZ6

    Protein attributes for TIPIN Gene

    Size:
    301 amino acids
    Molecular mass:
    34555 Da
    Quaternary structure:
    • Interacts with TIMELESS, which impairs TIMELESS self-association. Interacts with RPA2, PRDX2, MCM6 and MCM7.

neXtProt entry for TIPIN Gene

Post-translational modifications for TIPIN Gene

  • Ubiquitination at isoforms=117 and isoforms=101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TIPIN Gene

Domains & Families for TIPIN Gene

Gene Families for TIPIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TIPIN Gene

Suggested Antigen Peptide Sequences for TIPIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVW5

UniProtKB/Swiss-Prot:

TIPIN_HUMAN :
  • Belongs to the CSM3 family.
Family:
  • Belongs to the CSM3 family.
genes like me logo Genes that share domains with TIPIN: view

Function for TIPIN Gene

Molecular function for TIPIN Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.

Phenotypes From GWAS Catalog for TIPIN Gene

Gene Ontology (GO) - Molecular Function for TIPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 17102137
genes like me logo Genes that share ontologies with TIPIN: view
genes like me logo Genes that share phenotypes with TIPIN: view

Animal Model Products

miRNA for TIPIN Gene

miRTarBase miRNAs that target TIPIN

Clone Products

  • Addgene plasmids for TIPIN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIPIN Gene

Localization for TIPIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIPIN Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIPIN gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 17102137
GO:0005634 nucleus IDA,IEA 17102137
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0031298 replication fork protection complex IBA --
genes like me logo Genes that share ontologies with TIPIN: view

Pathways & Interactions for TIPIN Gene

genes like me logo Genes that share pathways with TIPIN: view

Gene Ontology (GO) - Biological Process for TIPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint IMP 17102137
GO:0000077 DNA damage checkpoint IEA --
GO:0006260 DNA replication TAS --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with TIPIN: view

No data available for SIGNOR curated interactions for TIPIN Gene

Drugs & Compounds for TIPIN Gene

No Compound Related Data Available

Transcripts for TIPIN Gene

mRNA/cDNA for TIPIN Gene

Unigene Clusters for TIPIN Gene

TIMELESS interacting protein:
Representative Sequences:

Clone Products

  • Addgene plasmids for TIPIN

Alternative Splicing Database (ASD) splice patterns (SP) for TIPIN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -

Relevant External Links for TIPIN Gene

GeneLoc Exon Structure for
TIPIN
ECgene alternative splicing isoforms for
TIPIN

Expression for TIPIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIPIN Gene

Protein differential expression in normal tissues from HIPED for TIPIN Gene

This gene is overexpressed in Urine (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIPIN Gene



Protein tissue co-expression partners for TIPIN Gene

NURSA nuclear receptor signaling pathways regulating expression of TIPIN Gene:

TIPIN

SOURCE GeneReport for Unigene cluster for TIPIN Gene:

Hs.744308
genes like me logo Genes that share expression patterns with TIPIN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIPIN Gene

Orthologs for TIPIN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIPIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPIN 34 33
  • 98.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TIPIN 34 33
  • 87.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TIPIN 34 33
  • 85.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tipin 16 34 33
  • 82 (n)
oppossum
(Monodelphis domestica)
Mammalia TIPIN 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIPIN 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPIN 34 33
  • 69.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPIN 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tipin 33
  • 63.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8214 33
zebrafish
(Danio rerio)
Actinopterygii tipin 34 33
  • 63.3 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10336 34
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSM3 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3163 34
  • 38 (a)
OneToOne
Species where no ortholog for TIPIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIPIN Gene

ENSEMBL:
Gene Tree for TIPIN (if available)
TreeFam:
Gene Tree for TIPIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIPIN: view image

Paralogs for TIPIN Gene

Pseudogenes.org Pseudogenes for TIPIN Gene

genes like me logo Genes that share paralogs with TIPIN: view

No data available for Paralogs for TIPIN Gene

Variants for TIPIN Gene

Sequence variations from dbSNP and Humsavar for TIPIN Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs112542693 likely-benign, Noonan syndrome, Cardio-facio-cutaneous syndrome 66,387,263(-) G/C upstream_transcript_variant
rs140749690 conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Rasopathy 66,387,416(-) C/T upstream_transcript_variant
rs141005341 likely-benign, Cardio-facio-cutaneous syndrome, Noonan syndrome 66,387,127(-) GCGCGCG/GCGCGCGCG upstream_transcript_variant
rs377720622 likely-benign, not specified, Rasopathy 66,387,353(-) C/G/T upstream_transcript_variant
rs536414539 likely-benign, Cardio-facio-cutaneous syndrome, Noonan syndrome 66,386,940(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TIPIN Gene

Variant ID Type Subtype PubMed ID
dgv1229n106 CNV deletion 24896259
esv1006740 CNV deletion 20482838
esv1418932 CNV deletion 17803354
esv2223439 CNV deletion 18987734
esv2552740 CNV deletion 19546169
esv2590993 CNV deletion 19546169
esv2749790 CNV deletion 23290073
esv3552586 CNV deletion 23714750
esv5372 CNV loss 18987735
esv6981 CNV loss 19470904
nsv1047588 CNV loss 25217958
nsv1070705 CNV deletion 25765185
nsv1148803 CNV deletion 26484159
nsv833045 CNV gain 17160897
nsv957954 CNV deletion 24416366

Variation tolerance for TIPIN Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIPIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIPIN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPIN Gene

Disorders for TIPIN Gene

Additional Disease Information for TIPIN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TIPIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIPIN Gene

Publications for TIPIN Gene

  1. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. (PMID: 17102137) Yoshizawa-Sugata N … Masai H (The Journal of biological chemistry 2007) 2 3 4 22 58
  2. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. (PMID: 17296725) Unsal-Kaçmaz K … Kaufmann WK (Molecular and cellular biology 2007) 3 4 22 58
  3. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. (PMID: 17116885) Chou DM … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
  4. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. (PMID: 12875843) Gotter AL (Journal of molecular biology 2003) 2 3 4 58
  5. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PMID: 20174623) Utge SJ … Paunio T (PloS one 2010) 3 44 58

Products for TIPIN Gene

Sources for TIPIN Gene

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