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Aliases for TXNL4B Gene

Aliases for TXNL4B Gene

  • Thioredoxin Like 4B 2 3 5
  • Dim1-Like Protein 3 4
  • DLP 3 4
  • Thioredoxin-Like Protein 4B 3
  • Thioredoxin-Like 4B 2
  • Dim2 3
  • DIM2 4

External Ids for TXNL4B Gene

Previous GeneCards Identifiers for TXNL4B Gene

  • GC16M070677
  • GC16M057885

Summaries for TXNL4B Gene

GeneCards Summary for TXNL4B Gene

TXNL4B (Thioredoxin Like 4B) is a Protein Coding gene. Diseases associated with TXNL4B include Anhaptoglobinemia. An important paralog of this gene is TXNL4A.

UniProtKB/Swiss-Prot for TXNL4B Gene

  • Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Gene Wiki entry for TXNL4B Gene

Additional gene information for TXNL4B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNL4B Gene

Genomics for TXNL4B Gene

GeneHancer (GH) Regulatory Elements for TXNL4B Gene

Promoters and enhancers for TXNL4B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J072092 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.6 574 3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B DHX38 TXNL4B ATXN1L IST1 AP1G1 DHODH ZNF19 CMTR2
GH16J072012 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 26 +80.8 80755 2.2 ATF1 NFIB ZFP64 YY1 TCF12 GATA2 EGR1 ZFP91 FOS CREM PKD1L3 TXNL4B HP HPR DHODH DHX38 PIR31360
GH16J072063 Promoter 1.1 EPDnew 11.5 +31.2 31224 0.1 ELF3 FOXA2 ARID4B THRB ZSCAN9 RAD21 RARA ATF7 CREM THAP11 HPR TXNL4B DHX38 HP
GH16J072072 Enhancer 1 ENCODE 11.9 +21.2 21217 2 FOXA2 ARID4B DMAP1 ZNF48 YY1 ZNF280A SLC30A9 TCF12 E2F8 ZFP91 HPR TXNL4B DHX38 IST1 DHODH ENSG00000260252
GH16J072124 Enhancer 1 Ensembl ENCODE 11.5 -30.8 -30830 1.5 HDGF RB1 MLX DMAP1 ZNF48 RAD21 ZNF614 ZNF143 RUNX3 CREM HP TXNL4B DHX38 HPR DHODH PIR57952 PMFBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TXNL4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TXNL4B gene promoter:
  • p53
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for TXNL4B Gene

Genomic Locations for TXNL4B Gene
50,143 bases
Minus strand
50,143 bases
Minus strand

Genomic View for TXNL4B Gene

Genes around TXNL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNL4B Gene

Proteins for TXNL4B Gene

  • Protein details for TXNL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin-like protein 4B
    Protein Accession:
    Secondary Accessions:
    • D3DWS6

    Protein attributes for TXNL4B Gene

    149 amino acids
    Molecular mass:
    17015 Da
    Quaternary structure:
    • Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.

    Three dimensional structures from OCA and Proteopedia for TXNL4B Gene

neXtProt entry for TXNL4B Gene

Post-translational modifications for TXNL4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TXNL4B Gene

Domains & Families for TXNL4B Gene

Gene Families for TXNL4B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TXNL4B Gene

Suggested Antigen Peptide Sequences for TXNL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DIM1 family.
  • Belongs to the DIM1 family.
genes like me logo Genes that share domains with TXNL4B: view

Function for TXNL4B Gene

Molecular function for TXNL4B Gene

UniProtKB/Swiss-Prot Function:
Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Phenotypes From GWAS Catalog for TXNL4B Gene

Gene Ontology (GO) - Molecular Function for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TXNL4B: view
genes like me logo Genes that share phenotypes with TXNL4B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNL4B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNL4B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNL4B Gene

Localization for TXNL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNL4B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNL4B gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IBA --
GO:0005682 U5 snRNP IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TXNL4B: view

Pathways & Interactions for TXNL4B Gene

SuperPathways for TXNL4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IBA --
GO:0000398 mRNA splicing, via spliceosome IEA --
GO:0006397 mRNA processing IEA --
GO:0007049 cell cycle IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with TXNL4B: view

No data available for Pathways by source and SIGNOR curated interactions for TXNL4B Gene

Drugs & Compounds for TXNL4B Gene

No Compound Related Data Available

Transcripts for TXNL4B Gene

Unigene Clusters for TXNL4B Gene

Thioredoxin-like 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TXNL4B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNL4B Gene

No ASD Table

Relevant External Links for TXNL4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNL4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNL4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNL4B Gene

This gene is overexpressed in Testis (20.1), Ovary (11.2), Salivary gland (8.3), Fetal testis (8.0), Stomach (7.3), and Esophagus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TXNL4B Gene

NURSA nuclear receptor signaling pathways regulating expression of TXNL4B Gene:


SOURCE GeneReport for Unigene cluster for TXNL4B Gene:


Evidence on tissue expression from TISSUES for TXNL4B Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with TXNL4B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNL4B Gene

Orthologs for TXNL4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNL4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNL4B 34 33
  • 100 (n)
(Canis familiaris)
Mammalia TXNL4B 34
  • 97 (a)
LOC612963 33
  • 93.51 (n)
(Monodelphis domestica)
Mammalia TXNL4B 34
  • 95 (a)
(Bos Taurus)
Mammalia TXNL4B 34 33
  • 92.39 (n)
(Rattus norvegicus)
Mammalia Txnl4b 33
  • 88.81 (n)
(Mus musculus)
Mammalia Txnl4b 16 34 33
  • 87.92 (n)
(Gallus gallus)
Aves TXNL4B 34 33
  • 81.66 (n)
(Anolis carolinensis)
Reptilia TXNL4B 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txnl4b 33
  • 78.97 (n)
Str.14990 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7085 33
(Danio rerio)
Actinopterygii txnl4b 34 33
  • 77.4 (n)
Dr.14498 33
fruit fly
(Drosophila melanogaster)
Insecta Dim1 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea Y54G2A.75 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIB1 34
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G24730 33
  • 61.74 (n)
(Oryza sativa)
Liliopsida Os11g0297900 33
  • 59.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9800 34
  • 36 (a)
Species where no ortholog for TXNL4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNL4B Gene

Gene Tree for TXNL4B (if available)
Gene Tree for TXNL4B (if available)
Evolutionary constrained regions (ECRs) for TXNL4B: view image

Paralogs for TXNL4B Gene

Paralogs for TXNL4B Gene

(1) SIMAP similar genes for TXNL4B Gene using alignment to 5 proteins:

  • H3BN11_HUMAN
  • H3BQ09_HUMAN
  • L8E8E2_HUMAN
genes like me logo Genes that share paralogs with TXNL4B: view

Variants for TXNL4B Gene

Sequence variations from dbSNP and Humsavar for TXNL4B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs104894517 affects, Anhaptoglobinemia 72,060,409(-) T/C genic_downstream_transcript_variant, intron_variant
rs137853233 benign, HAPTOGLOBIN, ALPHA-1, FAST-SLOW POLYMORPHISM 72,057,415(-) A/G genic_downstream_transcript_variant, intron_variant
rs778198124 uncertain-significance, Anhaptoglobinemia 72,056,547(-) CCCCCC/CCCCCCC genic_downstream_transcript_variant, intron_variant
rs1000101977 -- 72,073,170(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000154294 -- 72,072,906(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXNL4B Gene

Variant ID Type Subtype PubMed ID
dgv3017n100 CNV gain 25217958
esv2714683 CNV deletion 23290073
esv2758654 CNV gain 17122850
esv3306441 CNV mobile element insertion 20981092
esv3441283 CNV insertion 20981092
nsv428329 CNV gain 18775914
nsv7285 OTHER inversion 18451855
nsv833273 CNV loss 17160897

Variation tolerance for TXNL4B Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNL4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNL4B Gene

Disorders for TXNL4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXNL4B Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • ahp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TXNL4B

genes like me logo Genes that share disorders with TXNL4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNL4B Gene

Publications for TXNL4B Gene

  1. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. (PMID: 16142897) Simeoni F … Divita G (Biochemistry 2005) 3 4 22 58
  2. DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. (PMID: 15161931) Sun X … Shang Y (The Journal of biological chemistry 2004) 2 3 4 58
  3. Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. (PMID: 16511018) Jin T … Zhang YZ (Acta crystallographica. Section F, Structural biology and crystallization communications 2005) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TXNL4B Gene

Sources for TXNL4B Gene

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