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Aliases for UBE2R2 Gene

Aliases for UBE2R2 Gene

  • Ubiquitin Conjugating Enzyme E2 R2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2-CDC34B 3 4
  • E2 Ubiquitin-Conjugating Enzyme R2 3 4
  • Ubiquitin Carrier Protein R2 3 4
  • Ubiquitin-Protein Ligase R2 3 4
  • CDC34B 3 4
  • UBC3B 3 4
  • Ubiquitin Conjugating Enzyme E2R 2 3
  • Ubiquitin-Conjugating Enzyme E2 R2 3
  • Ubiquitin-Conjugating Enzyme UBC3B 3
  • Ubiquitin-Conjugating Enzyme E2R 2 2
  • EC 2.3.2.23 4
  • E2-CDC34B 3

External Ids for UBE2R2 Gene

Previous GeneCards Identifiers for UBE2R2 Gene

  • GC09P033987
  • GC09P033807
  • GC09P033774

Summaries for UBE2R2 Gene

Entrez Gene Summary for UBE2R2 Gene

  • Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2R2 Gene

UBE2R2 (Ubiquitin Conjugating Enzyme E2 R2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Protein ubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is CDC34.

UniProtKB/Swiss-Prot for UBE2R2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.

Gene Wiki entry for UBE2R2 Gene

Additional gene information for UBE2R2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2R2 Gene

Genomics for UBE2R2 Gene

GeneHancer (GH) Regulatory Elements for UBE2R2 Gene

Promoters and enhancers for UBE2R2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033813 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.8 -0.5 -452 6.9 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UBE2R2 B4GALT1 UBAP1 ENSG00000228352 PTENP1 PRSS3 ENSG00000260947 ENSG00000230074 UBAP2 DCAF12
GH09J033778 Enhancer 1.1 Ensembl ENCODE dbSUPER 18 -37.5 -37523 2 MEIS2 CTCF PKNOX1 JUN ZNF2 RAD21 ZNF7 YY1 ZNF791 PATZ1 UBE2R2 SMU1 TCEA1P4 NFX1 ENSG00000260947 TRBV29OR9-2 PRSS3
GH09J033749 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 11 -65.2 -65243 4.2 SOX13 TFAP4 FOXA2 SAP130 ARID4B MAX CEBPG YY1 EGR1 HNF4G PRSS3 ENSG00000260947 TRBV26OR9-2 RNU4ATAC11P UBE2R2 UBAP2 LINC01251 ENSG00000227301 NOL6 TRBV29OR9-2
GH09J033850 Enhancer 0.8 Ensembl dbSUPER 20.2 +33.4 33437 1.2 FOXA2 RFX1 SAP130 REST FOXA1 ZNF585B SCRT2 ZBTB17 UBE2R2 SNORD121A GC09P034283 ENSG00000200834
GH09J034046 Promoter/Enhancer 1.6 Ensembl ENCODE 8.4 +231.6 231572 3.9 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UBAP2 RN7SKP114 SMU1 ENSG00000228352 NFX1 NOL6 B4GALT1 UBE2R2 PRSS3 ENSG00000260947
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2R2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2R2 gene promoter:
  • ATF-2
  • E47
  • Bach1
  • GATA-1
  • LCR-F1
  • CREB
  • Pax-5
  • AML1a

Genomic Locations for UBE2R2 Gene

Genomic Locations for UBE2R2 Gene
chr9:33,817,164-33,920,404
(GRCh38/hg38)
Size:
103,241 bases
Orientation:
Plus strand
chr9:33,817,182-33,920,402
(GRCh37/hg19)
Size:
103,221 bases
Orientation:
Plus strand

Genomic View for UBE2R2 Gene

Genes around UBE2R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2R2 Gene

Proteins for UBE2R2 Gene

  • Protein details for UBE2R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q712K3-UB2R2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 R2
    Protein Accession:
    Q712K3
    Secondary Accessions:
    • D3DRL5
    • Q9NX64

    Protein attributes for UBE2R2 Gene

    Size:
    238 amino acids
    Molecular mass:
    27166 Da
    Quaternary structure:
    • When phosphorylated, interacts with beta-TrCP (BTRC).

neXtProt entry for UBE2R2 Gene

Post-translational modifications for UBE2R2 Gene

  • Ubiquitination at posLast=6363 and isoforms=11
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2R2 Gene

No data available for DME Specific Peptides for UBE2R2 Gene

Domains & Families for UBE2R2 Gene

Gene Families for UBE2R2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2R2 Gene

Suggested Antigen Peptide Sequences for UBE2R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q712K3

UniProtKB/Swiss-Prot:

UB2R2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2R2: view

Function for UBE2R2 Gene

Molecular function for UBE2R2 Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Enzyme Numbers (IUBMB) for UBE2R2 Gene

Phenotypes From GWAS Catalog for UBE2R2 Gene

Gene Ontology (GO) - Molecular Function for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with UBE2R2: view
genes like me logo Genes that share phenotypes with UBE2R2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2R2

CRISPR Products

miRNA for UBE2R2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2R2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2R2 Gene

Localization for UBE2R2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2R2 gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2R2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2R2 Gene

Pathways & Interactions for UBE2R2 Gene

genes like me logo Genes that share pathways with UBE2R2: view

UniProtKB/Swiss-Prot Q712K3-UB2R2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2R2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0006513 protein monoubiquitination IDA 20061386
GO:0016567 protein ubiquitination TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBE2R2: view

Drugs & Compounds for UBE2R2 Gene

(3) Drugs for UBE2R2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for UBE2R2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBE2R2: view

Transcripts for UBE2R2 Gene

mRNA/cDNA for UBE2R2 Gene

Unigene Clusters for UBE2R2 Gene

Ubiquitin-conjugating enzyme E2R 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2R2

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2R2 Gene

No ASD Table

Relevant External Links for UBE2R2 Gene

GeneLoc Exon Structure for
UBE2R2
ECgene alternative splicing isoforms for
UBE2R2

Expression for UBE2R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2R2 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for UBE2R2 Gene

This gene is overexpressed in Heart (19.5) and Cervix (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2R2 Gene



Protein tissue co-expression partners for UBE2R2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2R2 Gene:

UBE2R2

SOURCE GeneReport for Unigene cluster for UBE2R2 Gene:

Hs.643648

Evidence on tissue expression from TISSUES for UBE2R2 Gene

  • Lung(4.6)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with UBE2R2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2R2 Gene

Orthologs for UBE2R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
UBE2R2 34 33
  • 99.63 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia UBE2R2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2R2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2R2 34 33
  • 96.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2R2 34 33
  • 95.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2r2 16 34 33
  • 94.4 (n)
rat
(Rattus norvegicus)
Mammalia LOC689226 33
  • 94.12 (n)
chicken
(Gallus gallus)
Aves UBE2R2 34
  • 99 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
LOC427134 33
  • 88.66 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2R2 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2r2 33
  • 82.35 (n)
zebrafish
(Danio rerio)
Actinopterygii ube2r2 34 33
  • 79.64 (n)
OneToOne
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008680 33
  • 68.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7656 34 33
  • 68.25 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-3 34 33
  • 62.12 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL203C 33
  • 51.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC34 33
  • 50.45 (n)
UBC7 34
  • 44 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09196g 33
  • 47.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01188 33
  • 50.2 (n)
Species where no ortholog for UBE2R2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2R2 Gene

ENSEMBL:
Gene Tree for UBE2R2 (if available)
TreeFam:
Gene Tree for UBE2R2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2R2: view image

Paralogs for UBE2R2 Gene

Paralogs for UBE2R2 Gene

(6) SIMAP similar genes for UBE2R2 Gene using alignment to 2 proteins:

  • UB2R2_HUMAN
  • L8ECH4_HUMAN
genes like me logo Genes that share paralogs with UBE2R2: view

Variants for UBE2R2 Gene

Sequence variations from dbSNP and Humsavar for UBE2R2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000049227 -- 33,872,293(+) T/G intron_variant
rs1000063236 -- 33,888,962(+) T/A intron_variant
rs1000077579 -- 33,855,737(+) G/T intron_variant
rs1000085407 -- 33,853,493(+) C/T intron_variant
rs1000133740 -- 33,893,059(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2R2 Gene

Variant ID Type Subtype PubMed ID
esv23020 CNV loss 19812545
esv2656909 CNV deletion 23128226
esv2759690 CNV gain 17122850
esv2761525 CNV gain 21179565
esv3409915 CNV insertion 20981092
esv3620335 CNV gain 21293372
esv3620336 CNV loss 21293372
esv3620337 CNV loss 21293372
nsv1125318 OTHER inversion 24896259
nsv1132190 CNV deletion 24896259
nsv476684 CNV novel sequence insertion 20440878
nsv518977 CNV gain 19592680
nsv520467 CNV gain 19592680
nsv614152 CNV gain 21841781
nsv614153 CNV loss 21841781
nsv831541 CNV loss 17160897

Variation tolerance for UBE2R2 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2R2 Gene

Disorders for UBE2R2 Gene

Additional Disease Information for UBE2R2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UBE2R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2R2 Gene

Publications for UBE2R2 Gene

  1. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. (PMID: 12037680) Semplici F … Oliviero S (Oncogene 2002) 2 3 4 58
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  3. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 58
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for UBE2R2 Gene

Sources for UBE2R2 Gene

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